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Träfflista för sökning "WFRF:(Elfman M.) srt2:(2005-2009)"

Search: WFRF:(Elfman M.) > (2005-2009)

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Enumeration	Reference	Cover	Find
1.	Dunca, E, et al. (author) Using ocean quahog (Arctica islandica) shells to reconstruct palaeoenvironment in Öresund, Kattegat and Skagerrak, Sweden. 2009 In: International journal of earth sciences. - 1437-3254 .- 1437-3262. ; 98:1, s. 3-17 Journal article (peer-reviewed)
2.	Gleissman, H, et al. (author) Omega-3 docosahexaenoic acid inhibits neuroblastoma cell growth in vivo 2006 In: CANCER RESEARCH. - 0008-5472. ; 66:8 Conference paper (other academic/artistic)
3.	Johnsen, J I, et al. (author) Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo 2008 In: Oncogene. - : Springer Science and Business Media LLC. - 0950-9232 .- 1476-5594. ; 27:20, s. 2910-2922 Journal article (peer-reviewed)abstract Mammalian target of rapamycin (mTOR) has been shown to play an important function in cell proliferation, metabolism and tumorigenesis, and proteins that regulate signaling through mTOR are frequently altered in human cancers. In this study we investigated the phosphorylation status of key proteins in the PI3K/AKT/mTOR pathway and the effects of the mTOR inhibitors rapamycin and CCI-779 on neuroblastoma tumorigenesis. Significant expression of activated AKT and mTOR were detected in all primary neuroblastoma tissue samples investigated, but not in non-malignant adrenal medullas. mTOR inhibitors showed antiproliferative effects on neuroblastoma cells in vitro. Neuroblastoma cell lines expressing high levels of MYCN were significantly more sensitive to mTOR inhibitors compared to cell lines expressing low MYCN levels. Established neuroblastoma tumors treated with mTOR inhibitors in vivo showed increased apoptosis, decreased proliferation and inhibition of angiogenesis. Importantly, mTOR inhibitors induced downregulation of vascular endothelial growth factor A (VEGF-A) secretion, cyclin D1 and MYCN protein expression in vitro and in vivo. Our data suggest that mTOR inhibitors have therapeutic efficacy on aggressive MYCN amplified neuroblastomas. © 2008 Nature Publishing Group All rights reserved.
4.	Johnsen, JI, et al. (author) NSAIDs in neuroblastoma therapy 2005 In: Cancer letters. - : Elsevier BV. - 0304-3835. ; 228:1-2, s. 195-201 Journal article (peer-reviewed)
5.	Kim, J L, et al. (author) Current asthma and respiratory symptoms among pupils in relation to dietary factors and allergens in the school environment. 2005 In: Indoor Air. - 0905-6947. ; 15:3, s. 170-82 Journal article (peer-reviewed)
6.	Rasmuson, A, et al. (author) Neuroblastoma cells produce PGE(2) and express all four PGE(2) receptors: Implications for tumorigenesis 2009 In: CANCER RESEARCH. - 0008-5472. ; 69 Conference paper (other academic/artistic)

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Result 1-6 of 6

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Type of publication: journal article (4); conference paper (2)

Type of content: peer-reviewed (4); other academic/artistic (2)

Author/Editor: Elfman, L (5); Kogner, P (4); Johnsen, JI (3); Sveinbjornsson, B (3); Orrego, A (3); Lindskog, M (2); show more...; Ponthan, F (2); Johansson, M (1); Eksborg, S (1); Göransson, P (1); Henriksson, M (1); Rasmuson, A (1); Mörth, C. M. (1); Kim, J. L. (1); Segerstrom, L (1); Kågedal, Bertil, 194 ... (1); Norback, D. (1); Whitehouse, J. (1); Mi, Y. (1); Johnsen, J. I. (1); Dunca, E (1); Mutvei, H (1); Schone, R (1); Elfman, M (1); Baden, S.P. (1); Gleissman, H (1); Pettersen, I (1); Smedje, G (1); Simon-Santamaria, J (1); Fuskevag, OM (1); Koshnevis, M (1); show less...

University: Karolinska Institutet (4); Uppsala University (1); Stockholm University (1); Linköping University (1)

Language: English (6)

Research subject (UKÄ/SCB): Social Sciences (1)

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