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Träfflista för sökning "WFRF:(Enriquez J. E.) srt2:(2008-2009)"

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1.	Dong, Lan-Feng, et al. (author) Suppression of Tumor Growth In vivo by the Mitocan alpha-tocopheryl Succinate Requires Respiratory Complex II 2009 In: CLINICAL CANCER RESEARCH. - 1078-0432. ; 15:5, s. 1593-1600 Journal article (peer-reviewed)abstract Purpose: Vitamin E analogues are potent novel anticancer drugs. The purpose of this study was to elucidate the cellular target by which these agents, represented by alpha-tocopoheryl succinate (alpha-TOS), suppress tumors in vivo, with the focus on the mitochondrial complex II (CII). Experimental Design: Chinese hamster lung fibroblasts with functional, dysfunctional, and reconstituted CII were transformed using H-Ras. The cells were then used to form xenografts in immunocompromized mice, and response of the cells and the tumors to alpha-TOS was studied. Results: The CII-functional and CII-reconstituted cells, unlike their CII-dysfunctional counterparts, responded to alpha-TOS by reactive oxygen species generation and apoptosis execution. Tumors derived from these cell lines reciprocated their responses to alpha-TOS. Thus, growth of CII-functional and CII-reconstituted tumors was strongly suppressed by the agent, and this was accompanied by high level of apoptosis induction in the tumor cells. On the other hand, alpha-TOS did not inhibit the CII-dysfuntional tumors. Conclusions: We document in this report a novel paradigm, according to which the mitochondrial CII, which rarely mutates in human neoplasias, is a plausible target for anticancer drugs from the group of vitamin E analogues, providing support for their testing in clinical trials.
2.	Werdan, K, et al. (author) Immunoglobulin G treatment of postcardiac surgery patients with score-identified severe systemic inflammatory response syndrome--the ESSICS study 2008 In: Critical care medicine. - 1530-0293. ; 36:3, s. 716-723 Journal article (peer-reviewed)

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Andersson, J (1); Neuzil, Jiri (1); Werdan, K. (1); Brunk, Ulf (1); Goodwin, Jacob (1); Liu, JI (1); show more...; Dong, Lan-Feng (1); Freeman, Ruth (1); Zobalova, Renata (1); Marin-Hernandez, Alv ... (1); Stantic, Marina (1); Rohlena, Jakub (1); Valis, Karel (1); Rodriguez-Enriquez, ... (1); Butcher, Bevan (1); Witting, Paul K (1); Moreno-Sanchez, Rafa ... (1); Scheffler, Immo E (1); Ralph, Stephen J (1); Fraunberger, P (1); Mohr, FW (1); Haverich, A (1); Pilz, G (1); Mueller-Werdan, U (1); Enriquez, MM (1); Schmitt, DV (1); Neeser, G (1); Schoendube, F (1); Schaefers, HJ (1); Kreuzer, E (1); Thijs, LG (1); show less...

University: Linköping University (1); Karolinska Institutet (1)

Language: English (2)

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