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- Heldin, Carl-Henrik, et al.
(author)
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Platelet-derived growth factor : isoform-specific signalling via heterodimeric or homodimeric receptor complexes
- 1992
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In: Kidney International. - : Elsevier BV. - 0085-2538 .- 1523-1755. ; 41:3, s. 571-574
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Journal article (other academic/artistic)abstract
- Growth factors are polypeptides that are involved in the regulation of cell growth and differentiation, such as, during the embryonal development, in wound healing, in hematopoiesis, in the immune response, as well as in several adverse reactions including malignancies. Several families of structurally-related growth factors are known; new members of these families continue to be discovered and occasionally new families are found. One of the best characterized growth factor family is the platelet-derived growth factor (PDGF) family. PDGF was originally found to be present in the alpha-granules of platelets and to have growth promoting activity for fibroblasts and smooth muscle cells; subsequent studies have shown that PDGF is synthesized by a large number of different normal as well as transformed cell types, and that it acts not only on connective tissue cells but also on other types of cells [reviewed in 1, 2]. The present review summarizes some recent developments in the elucidation of the structural and functional properties of PDGF and PDGF receptors, the mechanism for PDGF signalling at the cellular level and the possible in vivo effects of PDGF.
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- Pihl-Karlsson, Gunilla, et al.
(author)
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Klöver som bioindikator för marknära ozon i Sverige - ett nationellt samarbetsprojekt
- 1993
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Reports (other academic/artistic)abstract
- Under sommaren 1993 har luftvårdsförbund och länsstyrelser medverkat i ett nationellt samarbete, 'Klöver - Sverige 1993' som initierades 1992 av IVL tillsammans med SLU, Röbäcksdalen, Umeå. I studien användes subklöver, Trifolium subterraneum, som bioindikator för marknära ozon. Under sommaren 1993 odlades subklöver i 15 län på 18 lokaler från Kalmar i Småland till Öjebyn i Norrbotten. Under sommarens försök har det på ett flertal platser varit svåra förhållanden för odling, d v s kallt och regnigt. Bäst förhållanden verkar ostkusten ha haft. Sammanfattningsvis kan sägas att ozonhalterna i Sverige under sommaren har varit ovanligt låga och skadorna på subklövern orsakade av ozon följaktligen varit av mycket begränsad omfattning.
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