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Träfflista för sökning "WFRF:(Falak R) srt2:(2015-2019)"

Search: WFRF:(Falak R) > (2015-2019)

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  • Bagheri, Y, et al. (author)
  • The Heterogeneous Pathogenesis of Selective Immunoglobulin A Deficiency
  • 2019
  • In: International archives of allergy and immunology. - : S. Karger AG. - 1423-0097 .- 1018-2438. ; 179:3, s. 231-245
  • Journal article (peer-reviewed)abstract
    • Selective immunoglobulin A deficiency (SIgAD) is the most prevalent type of primary immunodeficiency disorder. The phenotypic feature of SIgAD is related to a defect in B lymphocyte differentiation into plasma cell-producing immunoglobulin A (IgA). In this review, we summarize the recent advances in this regard. Genetic (including major histocompatibility complex [MHC] and non-MHC genes), immunologic (including B and T lymphocyte subsets abnormality), cytokines/chemokines and their related receptors, apoptosis and microbiota defects are reviewed. The mechanisms leading to SIgAD are most likely multifactorial and it can be speculated that several pathways controlling B cells functions or regulating epigenetic of the <i>IGHA</i> gene encoding constant region of IgA heavy chain and long-term survival of IgA switched memory B cells and plasma cells may be defective in different SIgAD patients.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Abolhassani, H (2)
Aghamohammadi, A (2)
Yazdani, R (2)
Bagheri, Y (2)
Falak, R (2)
Shekarabi, M (2)
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Mohammadi, J (1)
Azizi, G (1)
Babaha, F (1)
Sadri, M (1)
Sanaei, R (1)
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University
Karolinska Institutet (2)
Language
English (2)
Year
2019 (2)

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