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Sökning: WFRF:(Flock JI) > (2010-2014)

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1.
  • Frykberg, Lars, et al. (författare)
  • Antiphagocytic Function of an IgG Glycosyl Hydrolase from Streptococcus equi subsp equi and Its Use as a Vaccine Component
  • 2012
  • Ingår i: Infection and Immunity. - 0019-9567 .- 1098-5522. ; 80, s. 2914-2919
  • Tidskriftsartikel (refereegranskat)abstract
    • Endo Se from Streptococcus equi subsp. equi is an enzyme hydrolyzing glycosyl groups on IgG, analogous to EndoS from Streptococcus pyogenes. We here show that the activity of EndoSe leads to an antiphagocytic function and may thus be a contributory factor to immune evasion of S. equi. Despite the damaging effect that EndoSe has on IgG, antibodies against EndoSe can neutralize its function. Antibodies against EndoSe restored the opsonic activity of specific opsonizing antibodies. Mice infected with either S. equi subsp. equi or subsp. zooepidemicus or S. pyogenes could be protected by vaccination with EndoSe. It is speculated that EndoSe could be a suitable vaccine candidate against streptococcal infections.
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2.
  • Elbir, H, et al. (författare)
  • Ovine clone ST1464: a predominant genotype of Staphylococcus aureus subsp. anaerobius isolated from sheep in Sudan
  • 2010
  • Ingår i: Journal of infection in developing countries. - : Journal of Infection in Developing Countries. - 1972-2680. ; 4:4, s. 235-238
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The aim of the present study was to examine the phenotypic and genotypic relatedness of 17 Staphylococcus aureus subsp. anaerobius isolates recovered from sheep abscesses in Khartoum state, Sudan, during the period 2007-2008. Methodology: This sample was characterised using antibiogram typing, biochemical typing with the commercial PhenePlate system (PhP-CS) and multilocus sequence typing (MLST). Results: Low levels of resistance were noted to the 11 antimicrobial agents tested. All the isolates corresponded to a single PhP type, and to a single, novel, multilocus sequence type, designated ST1464.  Conclusion: These results demonstrate that the vast majority of cases of sheep abscess disease in Khartoum state are caused by a single novel clone of S. aureus subsp. anaerobius.
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