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- Feychting, M, et al.
(author)
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Dementia and occupational exposure to magnetic fields
- 1998
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In: Scandinavian journal of work, environment & health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 24:1, s. 46-53
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Journal article (peer-reviewed)
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- Seldén, Anders I., et al.
(author)
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Porphyrin Status in Aluminum Foundry Workers Exposed to Hexachlorobenzene and Octachlorostyrene
- 1999
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In: Archives of Environmental Health. - : Informa UK Limited. - 0003-9896. ; 54:4, s. 248-253
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Journal article (peer-reviewed)abstract
- The possible interference of hexachlorobenzene and octachlorostyrene (i.e., thermal byproducts from hexachloroethane in aluminum degassing) with porphyrin metabolism was investigated in exposed workers. Urine specimens from 9 male aluminum foundry workers (i.e., smelters) at 6 different companies and from 18 controls—matched for sex, age, residence, and socioeconomic status—were analyzed for total porphyrins and porphyrin isomers. Workers exposed to hexachlorobenzene and octachlorostyrene had a statistically significant increase in urinary total porphyrins, compared with controls (mean ± standard deviation: 13.63 ± 11.13 μmol/mol creatinine and 6.24 ± 3.84 μmol/mol creatinine, respectively; p = .02). The authors attributed the results mainly to differences in excretion of coproporphyrins—notably coproporphyrin III. Erythrocyte uroporphyrinogen decarboxylase activity was similar in both groups. There was a high correlation between levels of hexachlorobenzene and octachlorostyrene, respectively, in plasma and urinary excretion of porphyrins; these findings, however, relied heavily on 1 subject for whom extreme values were obtained. The results indicated that occupational exposure to hexachlorobenzene and octachlorostyrene in aluminum degassing with hexachloroethane may affect porphyrin metabolism in a manner consistent with early secondary coproporphyrinuria—the first recognized step in the development of chronic hepatic porphyria. It was also noted that changes remained detectable some years after exposure ceased.
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