3. |
- Sjöblom, K G, et al.
(author)
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Factors related to the progression of joint destruction in rheumatoid arthritis.
- 1984
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In: Scandinavian Journal of Rheumatology. - 1502-7732. ; 13:1, s. 21-27
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Journal article (peer-reviewed)abstract
- In 103 (M=25, F=78) of 150 consecutive RA patients, values of the following variables were obtained at the start and end of a 2-year follow-up period: radiographic destruction score of hands and feet according to Larsen (Larsen index), Ritchie index, B-hemoglobin, ESR and plasma proteins (α1-antitrypsin, ceruloplasmin, CRP, fibrinogen, haptoglobin, orosomucoid, IgA, IgG, IgM, C3 and C4). 60% of the values of ΔLI (final minus initial value of Larsen index) were significantly larger than zero (11-44 units, p<0.05). ΔLI was larger in females than in males (p=0.11). Comparing women with duration of disease (DoD) 1-6 years versus 7-52 years, ΔLI was larger in the former group (p=0.005). Comparing women with the largest ΔLI (19-44 units) with the remainder ones (ΔLI=-9-18 units), CRP and haptoglobin was higher and IgM lower in the former group (p=0.03, 0.02 and 0.03 respectively). In women with DoD 1-6 years (and only in this interval) significant linear relationships were found between ALI and hemoglobin (r-0.52, p<0.01) Ritchie index, haptoglobin, CRP (r=0.41-0.46, p<0.05) and IgM (r=-0.43, p<0.05). The mean of repeated hemoglobin values correlated even more strongly with ΔLI (r=0.70, p<0.001). ΔLI was predicted quite well by an expression linear in hemoglobin, fibrinogen and IgM (R=0.84). Similar results were obtained when male patients were included. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
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4. |
- Sjöblom, K G, et al.
(author)
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Plasma levels of beta-2 microglobulin in rheumatoid arthritis.
- 1980
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In: Annals of the Rheumatic Diseases. - 1468-2060. ; 39:4, s. 333-339
-
Journal article (peer-reviewed)abstract
- A simple and inexpensive method is described for the determination of beta 2-microglobulin (beta 2-MG) by enzyme-amplified single radial immunodiffusion. The values obtained with this method correlate well with those determined by means of a commerical RIA kit. Using the immunodiffusion method we have measured the plasma levels of beta 2-MG in 135 patients with rheumatoid arthritis (RA) and normal serum creatinine levels. 33% of the patients had increased concentrations of beta 2 MG, but the levels were found to correlate poorly with the values of several variables generally used as indices of the degree inflammatory activity in RA. Furthermore, in contrast to earlier claims to the contrary, beta 2-MG correlated positively with age. The value of beta 2-MG in plasma as an index of inflammatory activity in RA is questioned.
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