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- Friberg, Magnus
(författare)
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Tectonics of the middle Ural
- 2000
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis concerns the crustal structure and tectonic evolution of the Middle Urals. Theresults are based on near-vertical reflection seismic profiling, geological fieldobservations and single zircon geochronology,The Ural Mountains delimit. the eastern margin of Baltica. Prior to PalaeozoicUralian orogeny, this margin was bounded by an ocean. The closing of this ocean wassimultaneous with the formation of a series of intra-oceanic island-arcs during theSilurian and Devonian. In the Middle Urals, these arcs collided with Baltica during theLate Carboniferous and Early Permian. New isotope-age data show that high-grademetaigneous complexes in the hinterland are not microcontinents, as previouslythought, but rather the roots of the island-arcs. The reflection seismic data reveal that thearcs are separated from the continent and each other by major thrusts, that are E-dippingin the west and W-dipping in the east. The suture between Baltica and the accretedterranes is the Main Uralian Fault Zone (MUFZ), a complex E-dipping deformationzone that records both early suturing and later extension. Normal displacements are alsoobserved on faults in the hinterland, some normal movement probably occurring at thesame time as the collision, and some related to Triassic opening of the West SiberianBasin (WSB). The deposits of the WSB now cover large parts of the eastern MiddleUrals. The seismic data show prominent, sub-horizontal reflections from the lower crust(38 to 43 km depth) under the WSB and the Middle Urals, east of the MUFZ. The Moho is, in most places, interpreted to be at the base of this reflective band. However, directly east of the MUFZ and for 50 km eastwards, the Moho, as identified from other geophysical methods, is at c. 50 km depth, i.e. below the base of the sub-horizontal reflectivity. The features observed in the lower crust, based on their truncation of the Palaeozoic structures and by comparison with seismic data from other areas, are interpreted to have formed from crustal stretching and to be related to the opening of the WSB.
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- Hansson, Magnus, et al.
(författare)
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Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria.
- 2003
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Ingår i: Brain Research. - 1872-6240. ; 960:1-2, s. 99-111
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Tidskriftsartikel (refereegranskat)abstract
- The mitochondrial permeability transition (mPT) is considered to be an important mediator of apoptosis and necrosis, and is specifically blocked by cyclosporin A (CsA). CsA has been shown to exert a potent neuroprotective action in vivo when allowed to cross the blood–brain barrier in various animal models of acute neurological insults and neurodegenerative disease. The neuroprotective effect of CsA is considered to be mediated through specific inhibition of the mitochondrial permeability transition pore (mPTP) and through inhibition of neuronal calcineurin activity. Characterization of mPT has mainly been performed in liver and heart mitochondria, and some brain studies have reported a decreased inhibitory effect of CsA and questioned the importance of mPT in brain-derived mitochondria. We have used the de-energized model of swelling to examine the mPT in brain-derived non-synaptosomal mitochondria. Ca2+-induced swelling was evaluated by electron microscopy and by measurement of spectrophotometric alterations in light scattering. Permeability transition was readily induced in a majority of the mitochondria at a wide range of Ca2+ levels and was powerfully inhibited by CsA with a half-maximal effect at not, vert, similar23 nM CsA. The swelling kinetics and CsA effects were comparable to previous findings in de-energized liver and heart mitochondria. Careful characterization of mPT and CsA effects in brain-derived mitochondria is the first step in evaluating newly developed CsA analogues capable of crossing the blood–brain barrier and preferentially entering the brain. The importance of CsA causing a shift of the mitochondrial sensitivity to Ca2+ in neurological disorders is discussed.
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- Naredi, Silvana, 1953, et al.
(författare)
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Increased sympathetic nervous activity in patients with nontraumatic subarachnoid hemorrhage.
- 2000
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Ingår i: Stroke; a journal of cerebral circulation. - 0039-2499. ; 31:4, s. 901-6
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Tidskriftsartikel (refereegranskat)abstract
- Activation of the sympathetic nervous system, which leads to elevation of circulating catecholamines, is implicated in the genesis of cerebral vasospasm and cardiac aberrations after subarachnoid hemorrhage. To this juncture, sympathetic nervous testing has relied on indirect methods only.
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