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1.	Iotchkova, V, et al. (author) Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps 2018 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 50:12, s. 1752-1752 Journal article (peer-reviewed)
2.	Iotchkova, V, et al. (author) Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps 2016 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 48:11, s. 1303-1312 Journal article (peer-reviewed)
3.	Burren, OS, et al. (author) Chromosome contacts in activated T cells identify autoimmune disease candidate genes 2017 In: Genome biology. - 1474-760X. ; 18:1, s. 165- Journal article (peer-reviewed)
4.	de Jong, Jasper M. A., et al. (author) Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice 2019 In: Nature Metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 1:8, s. 830-843 Journal article (peer-reviewed)abstract Human and rodent brown adipose tissues (BAT) appear morphologically and molecularly different. Here we compare human BAT with both classical brown and brite/beige adipose tissues of 'physiologically humanized' mice: middle-aged mice living under conditions approaching human thermal and nutritional conditions, that is, prolonged exposure to thermoneutral temperature (approximately 30 degrees C) and to an energy-rich (high-fat, high-sugar) diet. We find that the morphological, cellular and molecular characteristics (both marker and adipose-selective gene expression) of classical brown fat, but not of brite/beige fat, of these physiologically humanized mice are notably similar to human BAT. We also demonstrate, both in silico and experimentally, that in physiologically humanized mice only classical BAT possesses a high thermogenic potential. These observations suggest that classical rodent BAT is the tissue of choice for translational studies aimed at recruiting human BAT to counteract the development of obesity and its comorbidities.

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Result 1-4 of 4

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Frontini, M (3); Chen, L (2); Huang, J. (2); Langenberg, C. (2); Amin, N (2); van Duijn, CM (2); show more...; Barbieri, C. (2); Jain, D (2); Hofman, A (2); Uitterlinden, AG (2); Timpson, NJ (2); Hamsten, A (2); Dehghan, A (2); Sabater-Lleal, M. (2); Dedoussis, G. (2); Marz, W. (2); Rivadeneira, F (2); Jiang, T. (2); Perry, JRB (2); Sennblad, B (2); Zeggini, E (2); Franke, L (2); Watkins, H (2); Gasparini, P. (2); Ntalla, I (2); Scott, RA (2); Toniolo, D (2); Lachance, G (2); Traglia, M (2); Swertz, MA (2); Franco, OH (2); Reiner, AP (2); Gaunt, TR (2); Zhang, WH (2); Kooperberg, C (2); Chambers, JC (2); Kooner, JS (2); Walter, K. (2); Auer, PL (2); Deelen, P (2); Gambaro, G (2); Franklin, CS (2); Southam, L (2); Soranzo, N (2); Malerba, G (2); Kleber, ME (2); Min, JL (2); Butterworth, A (2); Morris, JA (2); Farmaki, AE (2); show less...

University: Karolinska Institutet (3); Royal Institute of Technology (1); Stockholm University (1)

Language: English (4)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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