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Träfflista för sökning "WFRF:(GANNEDAHL G) srt2:(1992)"

Search: WFRF:(GANNEDAHL G) > (1992)

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  • Wanders, A., et al. (author)
  • Effect of LS-2616 on the graft protection achieved by cyclosporin A, prednisolone, and 15-deoxyspergualin in heart-transplanted rats
  • 1992
  • In: Transpl Int. ; 5 Suppl 1, s. S462-3
  • Journal article (peer-reviewed)abstract
    • The immunostimulator LS-2616 abolishes the effect of cyclosporin A in a rat cardiac transplantation model. The present paper compares the characteristics of rejection obtained under different immunosuppressive regimens with and without additional LS-2616 application in the same model. Cyclosporin A (CyA, 10 mg/kg daily), prednisolone (15 mg/kg daily), or 15-deoxyspergualin (2, 5, or 10 mg/kg daily), all given from the day of transplantation until day 9, protected the grafts during the treatment period. The addition of LS-2616 (160 mg/kg, day -1 until stop) resulted in a total abrogation of the immunosuppressive effect of CyA and prednisolone. However, LS-2616 could only partially or not at all reverse the effect of 15-deoxyspergualine. These results show a certain drug selectivity of LS-2616 in promoting rejection of immunosuppressed allografts. Further studies with LS-2616 may be of benefit in evaluating the mode of action of different immunosuppressive compounds and, thus, contribute to finding more effective antirejection therapies.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (3)
Author/Editor
Wanders, A (3)
Tufveson, G (3)
Gannedahl, G. (3)
Gerdin, Bengt, 1947- (2)
Gerdin, Bengt (1)
University
Uppsala University (3)
Umeå University (2)
Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Year
1992 (3)Undo refine

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