| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Hakman, M, et al.
(author)
-
Object-oriented biomedical system modeling - The Rationale
- 1999
-
In: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. - : ELSEVIER SCI IRELAND LTD. - 0169-2607. ; 59:1, s. 1-17
-
Journal article (other academic/artistic)abstract
- A short tutorial and a rationale for Object-Oriented Biomedical (Continuous) System Modelling (OOBSM) are given. The paper investigates and defines what is needed in order to make the work with complex bio-medical and pathophysiological models easier, les
|
|
| 5. |
- Hakman, M, et al.
(author)
-
Object-oriented biomedical system modelling - the language
- 1999
-
In: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. - : ELSEVIER SCI IRELAND LTD. - 0169-2607. ; 60:3, s. 153-181
-
Journal article (other academic/artistic)abstract
- The paper describes a new object-oriented biomedical continuous system modelling language (OOBSML). It is fully object-oriented and supports model inheritance, encapsulation, and model component instantiation and behaviour polymorphism. Besides the tradit
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Lindqvist, U, et al.
(author)
-
Evaluation of various models of hyaluronan kinetics for assessment of liver function
- 1997
-
In: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. - : SCANDINAVIAN UNIVERSITY PRESS. - 0036-5513. ; 57:1, s. 49-58
-
Journal article (other academic/artistic)abstract
- The purpose of this study of various models of hyaluronan kinetics has been to find the most appropriate model for estimation of parameters which characterize liver endothelial cell function. Five theoretical models for serum hyaluronan distribution and e
|
|
| 10. |
- Lindqvist, Ulla, et al.
(author)
-
Evaluation of various models of hyaluronan kinetics for assessment of liver function
- 1997
-
In: Scandinavian Journal of Clinical and Laboratory Investigation. - 0036-5513 .- 1502-7686. ; 57:1, s. 49-58
-
Journal article (peer-reviewed)abstract
- The purpose of this study of various models of hyaluronan kinetics has been to find the most appropriate model for estimation of parameters which characterize liver endothelial cell function. Five theoretical models for serum hyaluronan distribution and elimination were evaluated by computer analysis of serial measurements of the mass concentration of hyaluronan in serum following an intravenous bolus dose. Three of the models were based on one-compartment distribution of intravenously injected hyaluronan. Model 1A, with assumed first-order elimination, was found to be compatible with measured data and had identifiable parameters. Model 1B, with assumed non-linear Michaelis-Menten kinetics, was also found to be compatible but the Michaelis-Menten constant (K(m)) was not well determined. In model 1C, with non-linear Michaelis-Menten elimination kinetics, K(m) was set to a fixed value of 340 micrograms l-1, and the remaining parameters were well determined and the model was found to be compatible. Two models with an assumed two-compartment distribution of intravenously injected hyaluronan, were not acceptable due to unidentified parameters not discriminating between patients and healthy persons. In conclusion, model 1C, with one-compartment distribution and non-linear Michaelis-Menten kinetics, best fulfilled the criteria of validity and was accepted for further evaluation of clinical materials.
|
|
