SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Gallego Carlos) srt2:(2010-2014)"

Search: WFRF:(Gallego Carlos) > (2010-2014)

  • Result 1-3 of 3
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Bossini-Castillo, Lara, et al. (author)
  • A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort
  • 2011
  • In: Annals of the Rheumatic Diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 70:4, s. 638-641
  • Journal article (peer-reviewed)abstract
    • Objectives The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features. Methods A total of 8 European populations of Caucasian ancestry were included, comprising 3014 patients with SSc and 3125 healthy controls. Four genetic variants of TNFSF4 gene promoter (rs1234314, rs844644, rs844648 and rs12039904) were selected as genetic markers. Results A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively). Significant association of the four tested variants with patients with limited cutaneous SSc (lcSSc) was revealed (rs1234314 OR 1.22, 95% CI 1.07 to 1.38; rs844644 OR 0.91, 95% CI 0.83 to 0.99; rs844648 OR 1.10, 95% CI 1.01 to 1.20 and rs12039904 OR 1.20, 95% CI 1.09 to 1.33). Association of rs1234314, rs844648 and rs12039904 minor alleles with patients positive for anti-centromere antibodies (ACA) remained significant (OR 1.23, 95% CI 1.10 to 1.37; OR 1.12, 95% CI 1.01 to 1.25; OR 1.22, 95% CI 1.07 to 1.38, respectively). Haplotype analysis confirmed a protective haplotype associated with SSc, lcSSc and ACA positive subgroups (OR 0.88, 95% CI 0.82 to 0.96; OR 0.88, 95% CI 0.80 to 0.96; OR 0.86, 95% CI 0.77 to 0.97, respectively) and revealed a new risk haplotype associated with the same groups of patients (OR 1.14, 95% CI 1.03 to 1.26; OR 1.20, 95% CI 1.08 to 1.35; OR 1.23, 95% CI 1.07 to 1.42, respectively). Conclusions The data confirm the influence of TNFSF4 polymorphisms in SSc genetic susceptibility, especially in subsets of patients positive for lcSSc and ACA.
  •  
2.
  • Eriksson, Mårten, et al. (author)
  • Differences between girls and boys in emerging language skills : Evidence from 10 language communities
  • 2012
  • In: British Journal of Developmental Psychology. - Oxford : John Wiley & Sons. - 0261-510X .- 2044-835X. ; 30:2, s. 326-343
  • Journal article (peer-reviewed)abstract
    • The present study explored gender differences in emerging language skills in 13,783 European children from 10 non-English language communities. It was based on a synthesis of published data assessed with adapted versions of the MacArthur-Bates Communicative Development Inventories (CDIs) from age 0;08-2;06. The results showed that girls are slightly ahead of boys in early communicative gestures, in productive vocabulary and in combining words. The difference increased with age. Boys were not found to be more variable than girls. Despite extensive variation in language skills between language communities, the difference between girls and boys remained. This suggests that the difference is caused by robust factors that do not change between language communities.
  •  
3.
  • López, Miguel, et al. (author)
  • Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
  • 2010
  • In: Nature Medicine. - : Nature Publishing Group. - 1078-8956 .- 1546-170X. ; 16:9, s. 1001-1008
  • Journal article (peer-reviewed)abstract
    • Thyroid hormones have widespread cellular effects; however it is unclear whether their effects on the central nervous system (CNS) contribute to global energy balance. Here we demonstrate that either whole-body hyperthyroidism or central administration of triiodothyronine (T3) decreases the activity of hypothalamic AMP-activated protein kinase (AMPK), increases sympathetic nervous system (SNS) activity and upregulates thermogenic markers in brown adipose tissue (BAT). Inhibition of the lipogenic pathway in the ventromedial nucleus of the hypothalamus (VMH) prevents CNS-mediated activation of BAT by thyroid hormone and reverses the weight loss associated with hyperthyroidism. Similarly, inhibition of thyroid hormone receptors in the VMH reverses the weight loss associated with hyperthyroidism. This regulatory mechanism depends on AMPK inactivation, as genetic inhibition of this enzyme in the VMH of euthyroid rats induces feeding-independent weight loss and increases expression of thermogenic markers in BAT. These effects are reversed by pharmacological blockade of the SNS. Thus, thyroid hormone-induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (3)
Author/Editor
Witte, Torsten (1)
Ortego-Centeno, Norb ... (1)
Martin, Javier (1)
Lie, Benedicte A (1)
Nordin, Annika (1)
Orešič, Matej, 1967- (1)
show more...
Rueda, Blanca (1)
Hesselstrand, Roger (1)
Herrick, Ariane (1)
Worthington, Jane (1)
Denton, Christopher (1)
Fonseca, Carmen (1)
Riemekasten, Gabriel ... (1)
Vonk, Madelon C (1)
Beretta, Lorenzo (1)
Airó, Paolo (1)
Radstake, Timothy R ... (1)
Dieguez, Carlos (1)
Lopez, Miguel (1)
Eriksson, Mårten (1)
De Langhe, Ellen (1)
Westhovens, René (1)
Rodriguez-Cuenca, Se ... (1)
Vidal-Puig, Antonio (1)
Marschik, Peter B (1)
Bossini-Castillo, La ... (1)
Simeon, Carmen P. (1)
Castellvi, Ivan (1)
Carreira, Patricia (1)
Coenen, Marieke J. H ... (1)
Hunzelmann, Nicolas (1)
Kreuter, Alexander (1)
Koeleman, Bobby P. (1)
Voskuyl, Alexandre E ... (1)
Schuerwegh, Annemie ... (1)
Palm, Oyvind (1)
Scorza, Raffaella (1)
Shiels, Paul (1)
van Laar, Jacob M. (1)
Broen, Jasper C. A. (1)
Espinosa, Gerard (1)
Teresa Camps, Maria (1)
Navarrete, Nuria (1)
Gonzalez-Escribano, ... (1)
Vicente-Rabaneda, Es ... (1)
Rodriguez, Luis (1)
Tolosa, Carlos (1)
Roman-Ivorra, Jose A ... (1)
Gomez-Gracia, Inmacu ... (1)
Garcia-Hernandez, Fr ... (1)
show less...
University
University of Gävle (1)
Örebro University (1)
Lund University (1)
Karolinska Institutet (1)
Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Social Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view