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Träfflista för sökning "WFRF:(Gebre Medhin M.) "

Search: WFRF:(Gebre Medhin M.)

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  • Boström, Hans, et al. (author)
  • PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.
  • 1996
  • In: Cell. - : Elsevier BV. - 0092-8674. ; 85:6, s. 863-73
  • Journal article (peer-reviewed)abstract
    • A mouse platelet-derived growth factor A chain (PDGF-A) null allele is shown to be homozygous lethal, with two distinct restriction points, one prenatally before E10 and one postnatally. Postnatally surviving PDGF-A-deficient mice develop lung emphysema secondary to the failure of alveolar septation. This is apparently caused by the loss of alveolar myofibroblasts and associated elastin fiber deposits. PDGF alpha receptor-positive cells in the lung having the location of putative alveolar myofibroblast progenitors were specifically absent in PDGF-A null mutants. We conclude that PDGF-A is crucial for alveolar myofibroblast ontogeny. We have previously shown that PDGF-B is required in the ontogeny of kidney mesangial cells. The PDGFs therefore appear to regulate the generation of specific populations of myofibroblasts during mammalian development. The two PDGF null phenotypes also reveal analogous morphogenetic functions for myofibroblast-type cells in lung and kidney organogenesis.
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  • Carlwig, K., et al. (author)
  • Mandibulotomy access to tumour sites : fewer complications for postoperative compared with preoperative radiotherapy
  • 2021
  • In: International Journal of Oral and Maxillofacial Surgery. - : Elsevier BV. - 0901-5027. ; 50:7, s. 851-856
  • Journal article (peer-reviewed)abstract
    • The purpose of this study was to compare complication rates at the mandibulotomy site between patients receiving preoperative radiotherapy (RT) and those receiving postoperative RT during treatment for oral and oropharyngeal cancer where the surgical procedure required a mandibular osteotomy to gain access to the tumour. Sixty-four consecutive patients treated during the period 2000–2015 were available for analysis. Their medical records were reviewed retrospectively. All patients were followed for at least 1 year postoperatively. A subgroup of patients received RT on several occasions or long before the mandibulotomy, therefore the statistical comparisons focused on the two groups of patients receiving RT on one occasion and within 6 months prior to or following surgery. Seventeen patients presented a total of 29 complications, yielding an overall complication rate of 27%. Orocutaneous fistula was the most common complication. Patients who received RT preoperatively presented a higher complication rate (9/15; 60%) when compared to those who received RT postoperatively (2/31; 6.5%) (odds ratio 21.8, P < 0.001). This study demonstrated fewer complications in the mandibulotomy area exposed to postoperative RT compared with preoperative RT. It is therefore suggested that, when possible, RT should be given postoperatively if combination treatment with RT and surgery, including a mandibulotomy, is planned.
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  • Result 1-10 of 67
Type of publication
journal article (63)
other publication (3)
conference paper (1)
Type of content
peer-reviewed (52)
other academic/artistic (15)
Author/Editor
Greiner, T (13)
Hernell, O (6)
Eltom, M (4)
Betsholtz, C (3)
Michaelsen, KF (3)
Ahren, B (2)
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Elbagir, M (2)
Mulder, H. (2)
Zackrisson, Björn (2)
Ahmed, F (2)
Gustafsson, J (2)
Saarilahti, K (1)
Makitie, A (1)
Wigren, T (1)
Joensuu, H (1)
Sundqvist, J. (1)
Brown, R. (1)
Johansson, B (1)
Bengtsson, M (1)
Xu, XJ (1)
Fransson, P. (1)
Overgaard, J (1)
Nyman, Jan, 1956 (1)
Hammerlid, Eva, 1957 (1)
Johansson, C. (1)
Kämpe, O (1)
Kampe, O (1)
Berg, Gertrud, 1944 (1)
Nyström, Ernst, 1941 (1)
Blomqvist, L (1)
Wiesenfeld-Hallin, Z (1)
Nilsson, M (1)
Adell, Gunnar (1)
Jensen, K (1)
Fredholm, BB (1)
Halldner, L (1)
Herlenius, E (1)
Mertens, Fredrik (1)
Söderström, Karin (1)
Ohlsson, Claes, 1965 (1)
Hogmo, A. (1)
Gebre-Medhin, Maria (1)
Laurell, Göran (1)
Reizenstein, J. (1)
Notstam, I. (1)
Lovdahl, C (1)
Holmberg, Erik, 1951 (1)
Lindstedt, G (1)
Hedstrand, Håkan (1)
Kylberg, E (1)
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University
Uppsala University (50)
Karolinska Institutet (18)
Lund University (7)
University West (5)
University of Gothenburg (3)
Umeå University (3)
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Linköping University (2)
Örebro University (1)
Chalmers University of Technology (1)
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Language
English (60)
Swedish (7)
Research subject (UKÄ/SCB)
Medical and Health Sciences (14)

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