| 1. |
- Glans, Forouzan, et al.
(author)
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Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.
- 2008
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In: Diabetic Medicine: A journal of the British Diabetic Association. - : Wiley. - 1464-5491. ; 25:3, s. 303-307
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Journal article (peer-reviewed)abstract
- AIMS: To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients. METHODS: The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital. RESULTS: Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P < 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4 (0.02-1.19) vs. 0.4 (0.01-2.8), P = 0.005] than the Swedish group. A first-degree family history of diabetes was reported in 61% of immigrants, compared with 47% of Swedish-born (P = 0.022). CONCLUSIONS: Immigrants from the Middle-East have an earlier onset, stronger family history and more rapid decline of pancreatic B-cell function than Swedish patients, suggesting that they have a different form of T2DM compared with Swedish patients.
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| 2. |
- Tornberg, Åsa, et al.
(author)
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Assessment of exercise capacity in women with type 2 diabetes.
- 2008
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In: Clinical Physiology and Functional Imaging. - 1475-0961. ; 28, s. 294-298
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Journal article (peer-reviewed)abstract
- The primary aim of this study was to compare the maximal oxygen uptake as evaluated from a submaximal exercise test (EVO(2peak)) to direct measurements of VO(2peak) during a maximal exercise test as means of monitoring the aerobic endurance capacity in women with type 2 diabetes (T2D). Twenty-seven women with T2D participated in the study. The program consisted of combined group training 1 h twice a week during 12 weeks and walks 1 h per week. EVO(2 max) was estimated using a submaximal exercise test on a bicycle ergometer ad modumAstrand. VO(2peak) and maximal work rate were measured using an incremental maximal exercise test on an electrically braked bicycle ergometer at baseline and after 6 and 12 weeks. EVO(2peak)was higher than VO(2peak)at baseline and significantly higher at 12 weeks (EVO(2peak)1.92 +/- 0.54 l min(-1), VO(2peak) 1.41 +/- 0.36, P < 0.005). Maximal work rate increased significantly after 12 weeks (12 +/- 15, P < 0.005) compared to baseline. The main finding of this study was that EVO(2peak) assessed using a submaximal exercise test, systematically overestimated VO(2peak). The combined group training increased maximal work rate but not VO(2peak). This is likely to reflect peripheral adaptation to exercise and/or improved mechanical efficiency.
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