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Träfflista för sökning "WFRF:(Grabner M.) srt2:(2015-2019)"

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1.	Frank, David. C., et al. (author) Water-use efficiency and transpiration across European forests during the Anthropocene 2015 In: Nature Climate Change. - : Springer Science and Business Media LLC. - 1758-6798 .- 1758-678X. ; 5:6, s. 579-579 Journal article (peer-reviewed)
2.	Stiedl, P, et al. (author) Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis 2015 In: Hepatology (Baltimore, Md.). - : Ovid Technologies (Wolters Kluwer Health). - 1527-3350 .- 0270-9139. ; 61:2, s. 613-626 Journal article (peer-reviewed)
3.	Moll, HP, et al. (author) A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions 2019 In: Cancers. - : MDPI AG. - 2072-6694. ; 11:9 Journal article (peer-reviewed)abstract Genetically-engineered mouse models (GEMMs) lacking diseased-associated gene(s) globally or in a tissue-specific manner represent an attractive tool with which to assess the efficacy and toxicity of targeted pharmacological inhibitors. Stat3 and Stat5a/b transcription factors have been implicated in several pathophysiological conditions, and pharmacological inhibition of both transcription factors has been proposed to treat certain diseases, such as malignancies. To model combined inhibition of Stat3 and Stat5a/b we have developed a GEMM harboring a flox Stat3-Stat5a/b allele (Stat5/3loxP/loxP mice) and generated mice lacking Stat3 and Stat5a/b in hepatocytes (Stat5/3Δhep/Δhep). Stat5/3Δhep/Δhep mice exhibited a marked reduction of STAT3, STAT5A and STAT5B proteins in the liver and developed steatosis, a phenotype that resembles mice lacking Stat5a/b in hepatocytes. In addition, embryonic deletion of Stat3 and Stat5a/b (Stat5/3Δ/Δ mice) resulted in lethality, similar to Stat3Δ/Δ mice. This data illustrates that Stat5/3loxP/loxP mice are functional and can be used as a valuable tool to model the combined inhibition of Stat3 and Stat5a/b in tumorigenesis and other diseases.
4.	Stiedl, P, et al. (author) THE ROLE OF GROWTH HORMONE RECEPTOR IN LIVER FIBROSIS AND CANCER 2015 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 62, s. S792-S792 Conference paper (other academic/artistic)
5.	van Setten, GB, et al. (author) Immunohistochemical Detection of CTGF in the Human Eye 2016 In: Current eye research. - : Informa UK Limited. - 1460-2202 .- 0271-3683. ; 41:12, s. 1571-1579 Journal article (peer-reviewed)

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Type of publication: journal article (4); conference paper (1)

Type of content: peer-reviewed (4); other academic/artistic (1)

Author/Editor: Blaas, L (3); Müller, M. (2); Trauner, M (2); McMahon, R (2); Haybaeck, J (2); Claudel, T (2); show more...; Zollner, G (2); Pierre, M. (1); Haupt, M. (1); Ciais, P. (1); Ahlström, Anders (1); Sitch, S. (1); Poulter, B. (1); Friedlingstein, P. (1); Viovy, N. (1); Rulicke, T (1); Gutierrez, E (1); van Setten, GB (1); Konig, M. (1); Jungner, H. (1); Boettger, T (1); Frank, David C (1); Loader, N. J. (1); Andreu-Hayles, L. (1); Esper, J. (1); Waterhouse, J S (1); Szczepanek, M (1); Berninger, F. (1); Leuenberger, M. (1); Treydte, K. (1); Zimmermann, N. E. (1); Kessler, SM (1); Masson-Delmotte, V. (1); Huntingford, C. (1); Saracino, A (1); Saurer, M. (1); Helle, G. (1); Schleser, G. H. (1); Levis, S. (1); Lomas, M. (1); Bednarz, Z. (1); D`Alessandro, C. M. (1); Daux, V. (1); Filot, M. (1); Grabner, M. (1); Hilasvuori, E. (1); Kalela-Brundin, M. (1); Krapiec, M. (1); Marah, H. (1); Pazdur, A. (1); show less...

University: Karolinska Institutet (4); Lund University (1)

Language: English (5)

Research subject (UKÄ/SCB): Natural sciences (1)

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