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- Einarsson, Einar-Jon, et al.
(author)
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Long term hearing degeneration after platinum-based chemotherapy in childhood.
- 2010
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In: International Journal of Audiology. - : Informa UK Limited. - 1708-8186 .- 1499-2027. ; 49:10, s. 765-771
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Journal article (peer-reviewed)abstract
- The aim of this study was to investigate long-term development of hearing in subjects who had received platinum-based chemotherapy in childhood or adolescence. Another aim was to assess the self-reported hearing loss handicap and compare it to audiometric measurements. Medical records from individuals diagnosed with childhood cancer and treated with platinum-based chemotherapy between 1985 and 2000 at the University Hospital in Lund Sweden were reviewed retrospectively. Fifteen subjects, who fulfilled the eligibility criteria set for the study, underwent a thorough audiometric evaluation. The results show that the hearing loss, in subjects with ototoxicity had increased after the end of treatment, to include also the lower frequencies. The largest deterioration in hearing thresholds, up to 55 dB HL, was found at frequencies above 2 kHz. The findings also reveal that the subjects have a considerably greater hearing loss handicap and disability than would be expected from the results of the audiometric evaluations. The conclusion of this study is that children and adolescence treated with platinum-based chemotherapy should have regular audiometric follow-up examinations, also many years after the end of treatment. Furthermore, assessments of self-reported hearing disability should be made during and after chemotherapy.
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| 2. |
- Grenner, Jan
(author)
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Comments on Zazzio's Hyperacusis Study.
- 2012
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In: Photomedicine and Laser Surgery. - : Mary Ann Liebert Inc. - 1549-5418 .- 1557-8550. ; 30:7, s. 400-400
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Journal article (peer-reviewed)
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| 3. |
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| 4. |
- Grenner, Jan
(author)
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Significance of a notch in the otoacoustic emission stimulus spectrum.
- 2012
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In: Journal of Laryngology and Otology. - 1748-5460. ; 126:9, s. 897-901
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Journal article (peer-reviewed)abstract
- Objective: To explain a clinical observation: a notch in the stimulus spectrum during transient evoked otoacoustic emission measurement in ears with secretory otitis media. Methods: The effects of tympanic under-pressure were investigated using a pressure chamber. A model of the ear canal was also studied. Results: Tympanic membrane reflectance increased as a consequence of increased stiffness, causing a notch in the stimulus spectrum. In an adult, the notch could be clearly distinguished at an under-pressure of approximately -185 daPa. The sound frequency of the notch corresponded to a wavelength four times the ear canal length. The ear canal of infants was too short to cause a notch within the displayed frequency range. The notch was demonstrated using both Otodynamics and Madsen equipment. Conclusion: A notch in the otoacoustic emission stimulus spectrum can be caused by increased stiffness of the tympanic membrane, raising suspicion of low middle-ear pressure or secretory otitis media. This finding is not applicable to infants.
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