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Search: WFRF:(Gualandi Laura) > (2011)

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1.
  • Koch, Sina, et al. (author)
  • Signal transduction by vascular endothelial growth factor receptors
  • 2011
  • In: Biochemical Journal. - 0264-6021 .- 1470-8728. ; 437, s. 169-183
  • Research review (peer-reviewed)abstract
    • VEGFs (vascular endothelial growth factors) control vascular development during embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There are five related mammalian ligands, which act through three receptor tyrosine kinases. Signalling is modulated through neuropilins, which act as VEGF co-receptors. Heparan sulfate and integrins are also important modulators of VEGF signalling. Therapeutic agents that interfere with VEGF signalling have been developed with the aim of decreasing angiogenesis in diseases that involve tissue growth and inflammation, such as cancer. The present review will outline the current understanding and consequent biology of VEGF receptor signalling.
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2.
  • Tugues, Sonia, et al. (author)
  • Vascular endothelial growth factors and receptors : Anti-angiogenic therapy in the treatment of cancer
  • 2011
  • In: Molecular Aspects of Medicine. - : Elsevier BV. - 0098-2997 .- 1872-9452. ; 32:2, s. 88-111
  • Research review (peer-reviewed)abstract
    • Vascular endothelial growth factors (VEGFs) are critical regulators of vascular and lymphatic function during development, in health and in disease. There are five mammalian VEGF ligands and three VEGF receptor tyrosine kinases. In addition, several VEGF co-receptors that lack intrinsic catalytic activity, but that indirectly modulate the responsiveness to VEGF contribute to the final biological effect. This review describes the molecular features of VEGFs. VEGFRs and co-receptors with focus on their role in the treatment of cancer.
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  • Result 1-2 of 2
Type of publication
research review (2)
Type of content
peer-reviewed (2)
Author/Editor
Claesson-Welsh, Lena (2)
Li, Xiujuan (2)
Tugues, Sonia (2)
Koch, Sina (2)
Gualandi, Laura (2)
University
Uppsala University (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2011 (2)Undo refine

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