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- Eriksson, Mikael, et al.
(author)
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Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible targets
- 1999
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In: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 190:7, s. 1005-1012
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Journal article (peer-reviewed)abstract
- Inhibitory receptors expressed on natural killer (NK) cells abrogate positive signals upon binding corresponding major histocompatibility complex (MHC) class I molecules on various target cells. By directly micromanipulating the effector-target cell encounter using an optical tweezers system which allowed temporal and spatial control, we demonstrate that Ly49-MHC class I interactions prevent characteristic cellular responses in NK cells upon binding to target cells. Furthermore, using this system, we directly demonstrate that an NK cell already bound to a resistant target cell may simultaneously bind and kill a susceptible target cell. Thus, although Ly49-mediated inhibitory signals can prevent many types of effector responses, they do not globally inhibit cellular function, but rather the inhibitory signal is spatially restricted towards resistant targets.
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3. |
- Start, DFH, et al.
(author)
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Bulk ion heating with ICRH in JET DT plasmas
- 1999
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In: NUCLEAR FUSION. - 0029-5515. ; 39:3, s. 321-336
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Journal article (peer-reviewed)abstract
- Reactor relevant ICRH scenarios have been assessed during DT experiments on the JET tokamak using H mode divertor discharges with ITER-like shapes and safety factors. Deuterium minority heating in tritium plasmas was demonstrated for the first time. For 9
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