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- Albertsson-Wikland, Kerstin, 1947, et al.
(author)
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Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency
- 2008
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In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 93:11, s. 4342-4350
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Journal article (peer-reviewed)abstract
- CONTEXT: The effect of GH therapy in short non-GH-deficient children, especially those with idiopathic short stature (ISS), has not been clearly established owing to the lack of controlled trials continuing until final height (FH).OBJECTIVE: The aim of the study was to investigate the effect on growth to FH of two GH doses given to short children, mainly with ISS, compared with untreated controls.DESIGN AND SETTING: A randomized, controlled, long-term multicenter trial was conducted in Sweden.INTERVENTION: Two doses of GH (Genotropin) were administered, 33 or 67 microg/kg.d; control subjects were untreated.SUBJECTS: A total of 177 subjects with short stature were enrolled. Of these, 151 were included in the intent to treat (AllITT) population, and 108 in the per protocol (AllPP) population. Analysis of ISS subjects included 126 children in the ITT (ISSITT) population and 68 subjects in the PP (ISSPP) population.MAIN OUTCOME MEASURES: We measured FH sd score (SDS), difference in SDS to midparenteral height (diff MPHSDS), and gain in heightSDS.RESULTS: After 5.9+/-1.1 yr on GH therapy, the FHSDS in the AllPP population treated with GH vs. controls was -1.5+/-0.81 (33 microg/kg.d, -1.7+/-0.70; and 67 microg/kg.d, -1.4+/-0.86; P<0.032), vs. -2.4+/-0.85 (P<0.001); the diff MPHSDS was -0.2+/-1.0 vs. -1.0+/-0.74 (P<0.001); and the gain in heightSDS was 1.3+/-0.78 vs. 0.2+/-0.69 (P<0.001). GH therapy was safe and had no impact on time to onset of puberty. A dose-response relationship identified after 1 yr remained to FH for all growth outcome variables in all four populations.CONCLUSION: GH treatment significantly increased FH in ISS children in a dose-dependent manner, with a mean gain of 1.3 SDS (8 cm) and a broad range of response from no gain to 3 SDS compared to a mean gain of 0.2 SDS in the untreated controls.
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| 3. |
- Andersson, Björn, et al.
(author)
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Advective collisions
- 2007
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In: Europhysics Letters. - : IOP Publishing. - 0295-5075 .- 1286-4854. ; 80
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Journal article (peer-reviewed)
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| 5. |
- Barkah, Dani, et al.
(author)
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Evaluation of Automatic Flow Analysis for WCET Calculation on Industrial Real-Time System Code
- 2008
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In: Proceedings - Euromicro Conference on Real-Time Systems, 2008. - 9780769532981 ; , s. 331-340
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Conference paper (peer-reviewed)abstract
- A static Worst-Case Execution Time (WCET) analysis derives upper bounds for the execution times of programs. Such analysts requires information about the possible program flows. The current practice is to provide this information manually, which can be laborious and error-prone. An alternative is to derive this information through an automated flow analysis. In this article, we present a case study where an automatic flowanalysis method was tested on industrial real-time system code. The same code was the subject of an earlier WCET case study, where it was analysed using manual annotations for the flow information. The purpose of the current study was to see to which extent the same flow information could be found automatically. The results show that for the most part this is indeed possible, and we could derive comparable WCET estimates using the automatically generated flow information. In addition, valuable insights were gained on what is needed to make flow analysis methods work on real production code.
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| 6. |
- Biterman, Danuta, et al.
(author)
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Economic and Ethnic Polarisation among Children in Sweden's Three Metropolitan Areas
- 2008
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In: Schmollers Jahrbuch. Journal of Applied Social Science Studies. - 1439-121X. ; 128:1, s. 121-152
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Journal article (peer-reviewed)abstract
- This paper investigates certain issues of economic and ethnic segregation from the perspective of children in the three metropolitan regions of Sweden by using a relative new operationalization of the neighbourhood concept. Neighbourhoods are clustered by population share of visible immigrants in proportion to share of native born residents. The target variable under study is child income based on income of parents. Inequality in child income 1990, 1996 and 2002 is studied by decomposing additively decomposable inequality indexes. Based on this, measures of residential economic polarisation and residential ethnic polarisation are obtained. Of major significance is that residential polarisation increased for all three regions and for both sub-periods 1990-1996 and 1996-2002. For example, while in the Stockholm region 7 percent of inequality in child income in 1990 was due to differences in mean income across neighbourhoods, the proportion had increased to as much as 22 percent in 2002. Ethnic residential polarisation increased as well and we report a relatively large overlap between economic and ethnic polarisation. Based on estimated regression models, we conclude that increased returns to parental education have forcefully contributed to larger economic polarisation among children in Swedish metropolitan regions.
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| 9. |
- Blume, Kraen, et al.
(author)
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At the Lower End of the Table: Determinants of Poverty among Immigrants to Denmark and Sweden
- 2007
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In: Journal of Ethnic and Migratoin Studies. - 1369-183X. ; 33:3
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Journal article (peer-reviewed)abstract
- In this paper we study determinants of relative poverty among immigrants and natives in Denmark and Sweden during the 1980s and 1990s. Denmark and Sweden share the same properties in a range of labour market and welfare state characteristics. At the same time they differ very much in cyclical profiles and immigration experiences during recent decades. Both countries have followed the same principles regarding immigration policy, i.e. immigration from low income countries has been restricted to tied movers and refugees. We use 60 percent of the median in the distribution of equivalent disposable as poverty line. Data comes from two large panels based on administrative data. We find that immigrants have higher poverty rates than natives in both countries and that this difference has clearly increased in both countries. The paper reports results based on running probability models of poverty incidence. Explanatory variables include measures of years since immigration, demographic characteristics, and variables measuring country of origin. We conclude that a significant part of the difference in aggregate immigrant poverty rates reflect differences in composition by country of origin and differences in the structure of benefits to families with children.
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