| 1. |
- Landin-Olsson, Mona, et al.
(author)
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Immunoreactive trypsin(Ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls
- 1990
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In: Pancreas. - : Ovid Technologies (Wolters Kluwer Health). - 0885-3177. ; 5:3, s. 241-247
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Journal article (peer-reviewed)abstract
- To evaluate the exocrine pancreatic function at the time of diagnosis of insulin-dependent diabetes mellitus, we determined immunoreactive an-odal and cathodal trypsin(ogen) levels in sera from almost all children (n = 375) 0-14 years of age in Sweden in whom diabetes developed during 1 year, and in sex-, age-, and geographically matched control subjects (n = 312). The median level of anodal trypsin(ogen) was 5 (quartile range, 3-7) µg/L in children with newly diagnosed diabetes, compared with a median level of 7 (quartile range, 4-8) µg/L in control subjects (p < 0.0001). Similarly, the median level of cathodal trypsin(ogen) was 8 (quartile range, 4-10) µg/L in children with diabetes, compared with a median level of 11 (quartile range, 7-15) µg/L in control subjects (p < 0.0001). The median of the individual ratios between cathodal and anodal trypsin(ogen) was 1.4 in the diabetic patients and 1.7 in the control children (p < 0.001). In a multivariate test, however, only the decrease in cathodal trypsin(ogen) concentration was associated with diabetes. The levels of trypsin(ogen)s did not correlate with levels of islet cell antibodies, present in 81% of the diabetic children. Several mechanisms may explain our findings, for example, similar pathogenetic factors may affect both the endocrine and exocrine pancreas simultaneously, a failing local trophic stimulation by insulin on the exocrine cells may decrease the trypsinogen production, and there may be an increased elimination of trypsin(ogen) because of higher filtration through the kidneys in the hyperglycemic state.
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| 2. |
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| 3. |
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| 4. |
- Gustavsson, Peter, et al.
(author)
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Learning to Glocalize
- 1994
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In: Advances in Strategic Management. - 0742-3322. ; 10 B, s. 255-288
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Journal article (peer-reviewed)
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| 5. |
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| 6. |
- Henningson, Dan S., et al.
(author)
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Localized disturbances in parallel shear flows
- 1994
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In: Applied Scientific Research. - 0003-6994 .- 2212-0939. ; 53:1-2, s. 51-97
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Journal article (peer-reviewed)abstract
- The development of localized disturbances in parallel shear flows is reviewed. The inviscid case is considered, first for a general velocity profile and then in the special case of plane Couette flow so as to bring out the key asymptotic results in an explicit form. In this context, the distinctive differences between the wave-packet associated with the asymptotic behavior of eigenmodes and the non-dispersive (inviscid) continuous spectrum is highlighted. The largest growth is found for three-dimensional disturbances and occurs in the normal vorticity component. It is due to an algebraic instability associated with the lift-up effect. Comparison is also made between the analytical results and some numerical calculations. Next the viscous case is treated, where the complete solution to the initial value problem is presented for bounded flows using eigenfunction expansions. The asymptotic, wave-packet type behaviour is analyzed using the method of steepest descent and kinematic wave theory. For short times, on the other hand, transient growth can be large, particularly for three-dimensional disturbances. This growth is associated with cancelation of non-orthogonal modes and is the viscous equivalent of the algebraic instability. The maximum transient growth possible to obtain from this mechanism is also presented, the so called optimal growth. Lastly the application of the dynamics of three dimensional disturbances in modeling of coherent structures in turbulent flows is discussed.
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| 7. |
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