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- Ekbladh, Elin, et al.
(author)
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Perceptions of the work environment among people with experience of long term sick leave
- 2010
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In: Work. - 1051-9815 .- 1875-9270. ; 35:2, s. 125-136
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Journal article (peer-reviewed)abstract
- Purpose: The aims were to describe and analyze how people with experience of long term sick leave perceive that factors in their work environment support or interfere with work performance, satisfaction, and well-being. Method: The 53 participants were interviewed with the Work Environment Impact Scale (WEIS). The WEIS ratings and belonging notes were analyzed by descriptive statistics and qualitative analysis respectively. Differences in WEIS ratings between; women and men; participants with somatic and mental diseases; and participants working and on full-time sick leave were tested. Results: The most supportive factors concerned social interactions at work, and the value and meaning of work. The factors perceived as most interfering concerned work demands and rewards. The social relations at work were perceived as more supportive by the working group than by those on full-time sick leave. The participants with somatic diseases perceived physical work factors as more interfering than did participants with mental diseases, who in turn perceived the value and meaning of work as more interfering. Conclusion: Knowledge about the interaction between the worker and the work environment could reveal useful information about the complex phenomenon of reducing sick leave. The WEIS seems useful in providing information about how alterations and accommodations in the work environment could support individual workers.
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- Ekbladh, Elin, et al.
(author)
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Return to work : the predictive value of the Worker Role Interview (WRI) over two years
- 2010
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In: Work. - 1051-9815 .- 1875-9270. ; 35:2, s. 163-172
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Journal article (peer-reviewed)abstract
- Worker Role Interview (WRI) is an assessment tool designed to identify psychosocial and environmental factors which influence a persons ability to return to work. The purpose of this study was to investigate if the Worker Role Interview (WRI) can predict return to work over a period of two years. Fifty three long-term sick-listed people were interviewed and rated with the WRI. Differences in ratings and the ability of WRI to correctly predict whether these people would fall into the working or non-working groups at 6, 12 and 24 month follow-ups were tested by Mann-Whitney test and logistic regression respectively. Eight of 17 items in WRI were rated differently between the groups at one or more of the follow-ups. The regression models based on the WRI ratings had an overall correct prediction rate ranging from 81% to 96%. Expectation of job success which concerns the persons belief in abilities in relation to return to work emerged as an important predictive factor for return to work in all statistical analyses. The WRI assessment contains items that could predict return to work. This implies that the WRI could be a useful tool in vocational rehabilitation for identifying individual rehabilitation needs.
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- Felth, Jenny, 1979-, et al.
(author)
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Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system
- 2013
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In: Investigational new drugs. - : Springer Science and Business Media LLC. - 0167-6997 .- 1573-0646. ; 31:3, s. 587-598
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Journal article (other academic/artistic)abstract
- Gambogic acid (GA), displays cytotoxicity towards a wide variety of tumor cells and has been shown to affect many important cell-signaling pathways. In the present work, we investigated the mechanism of action of GA by analysis of drug-induced changes in gene expression profiles and identified GA and the derivative dihydro GA as possible inhibitors of the ubiquitin-proteasome system (UPS). Both GA and dihydro GA inhibited proteasome function in cells resulting in the accumulation of polyubiquitin complexes. In vitro experiments showed that both GA and dihydro GA inhibited 20S chymotrypsin activity and the inhibitory effects of GA and dihydro GA on proteasome function corresponded with apoptosis induction and cell death. In conclusion, our results show that GA and dihydro GA exert their cytotoxic activity through inhibition of the UPS, specifically by acting as inhibitors of the chymotrypsin activity of the 20S proteasome.
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- Günther, Göran, et al.
(author)
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Ticke-borne encephalitis is associated with low levels of interleukin-10 in cerebrospinal fluid
- 2011
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In: Infection Ecology & Epidemiology. - : Informa UK Limited. - 2000-8686. ; 1, s. 6029-
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Journal article (peer-reviewed)abstract
- Tick-borne encephalitis (TBE) is associated with higher morbidity and induces a stronger intrathecal immune activation than most other viral induced meningo-encephalitis. The aim of this study was to investigate cytokine concentrations in cerebrospinal fluid (CSF) and serum in relation to aetiology and clinical course. Cytokines were analysed by Enzyme-linked Immuno Assay (ELISA) from 44 patients with TBE and from 36 patients with aseptic meningo-encephalitis of other aetiology (non-TBE). Significantly increased CSF levels of Interferon-γ (IFN-γ), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Interleukin-1 receptor antagonist (IL- 1ra), and soluble CD8 receptor (sCD8) were detected in both cohorts. Tumour necrosis factor-α (TNF-α showed low levels or was not detected in CSF in any group in the acute stage. However, the CSF levels of IL- 10 were significantly lower in TBE than in non-TBE cases 06 days after onset of encephalitis. The TBE patients with encephalitis had significantly lower IL-10 CSF levels later in the clinical course (day 718) than TBE patients with meningeal disease. Increased IFN-γ production, but low IL-10 secretion, may be of pathophysiological significance in TBE.
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| 8. |
- Haglund, Lars, 1949-
(author)
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Högskoleutbildning som förbereder för arbetslivet : Gymnasister, campusstudenter, distansstudenter och alumner om att utbilda sig till ett yrke
- 2014
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Reports (other academic/artistic)abstract
- Det finns många åsikter kring universitetsutbildningar och yrkesorientering. Frågan om hur man hittar en god balans mellan teori och praktik är ett vanligt diskussionsämne i föreläsningssalar, seminarierum och kaffehörnor på högskolor och universitet. Under ett antal år har vi vid Karlstads universitet genomfört olika enkätundersökningar där vi ställt frågor som kan relateras till yrkesorientering och balans mellan teori och tillämpning/praktik i studierna. I denna rapport sammanfattas svar från gymnasister på besök på universitetet, våra studenter som läser på Campus, våra studenter på distans och från våra alumner på frågor om utbildning och yrkesliv.
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| 9. |
- Haglund, Lars, 1949-
(author)
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Kunskap är inget värd utan förmågan att kunna använda den : Träning av färdigheter i högskoleutbildning
- 2014
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Reports (other academic/artistic)abstract
- Hur kan vi genom vår universitetsutbildning i Karlstad utveckla våra studenters olika förmågor? Viktiga ting som förmåga att arbeta i grupp, tala väl och skriva väl är tema för den här rapporten. För drygt 10 år sedan formulerade vi inriktningen vad gäller några av dessa ting i Vision 2015 för vårt universitet:I vår utbildning och forskning balanserar vi värderingar, vetande och praktisk förmåga. Vad har hänt den praktiska träningen av olika förmågor? Hur har vi lyckats med våra föresatser att balansera olika moment i utbildningen? Vi har under ett antal år vid Karlstads universitet genomfört olika enkätundersökningar där studenter svarat på frågor som kan relateras till frågan hur färdighetsträning inkluderas i studierna. I föreliggande rapport sammanfattas resultat från dessa olika studier.
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| 10. |
- Haglund, Lars, 1949-
(author)
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Market and Service Orientation of Public Transportation : Swedish-Indonesian Cooperation Transportation Research and Education 2000 to 2010
- 2011
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Reports (other academic/artistic)abstract
- This is anaccount of a program of research cooperation within the field of publictransportation. The University of Gajah Mada in Yogyakarta, Indonesian andKarlstad University in Sweden has worked together in this program. The reformedand re-organized systems of public transportation in Sweden and Indonesia havebeen the topics of exchange. The program started around 2000 and has developedover some 10 years. The Service and Market Oriented Research Group (SAMOT) at Karlstad University conducts multidisciplinary and internationally recognized research via active collaboration with trade and industry, public sector players, and universities. In doing so, SAMOT will contribute to the long-term sustainable development of passenger transportation services.
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