| 1. |
- Haglund, Nils, et al.
(author)
-
Improvement of Autism Symptoms After Comprehensive Intensive Early Interventions in Community Settings
- 2021
-
In: Journal of the American Psychiatric Nurses Association. - : SAGE Publications. - 1078-3903 .- 1532-5725. ; 27:6, s. 483-495
-
Journal article (peer-reviewed)abstract
- BACKGROUND: Preschool children with autism in southern Sweden participated in a comprehensive Naturalistic Developmental Behavioral Intervention (NDBI) program. AIMS: To evaluate the ongoing NDBI program by comparing the pre- and postintervention outcomes in terms of improved autism symptom severity. METHOD: The improvement of Autism Diagnostic Observation Schedule (ADOS-R) test results between baseline and evaluation among children participating in the NDBI program (n = 67) was compared with the results among children receiving community treatment as usual (n = 27) using analysis of covariance. RESULTS: The study showed that children in the NDBI group improved their ADOS-R total scores between baseline and evaluation (-0.8 scores per year; 95% CI [-1.2, -0.4]), whereas no improvement was detected in the comparison group (+0.1 scores per year; 95% CI [-0.7, +0.9]). The change in the NDBI group versus the change in the comparison group was statistically significant after adjusting for possible confounders as well. Children in the NDBI group also significantly improved their ADOS severity scores, but the scores were not significantly different from those of the comparison group. CONCLUSIONS: The results from the current naturalistic study must be interpreted cautiously, but they do support earlier studies reporting on improvement of autism symptoms after early intensive interventions. Results from observational studies are difficult to interpret, but it is nevertheless of uttermost importance to evaluate costly autism intervention programs. The results do indicate that children with autism benefit from participating in early comprehensive intensive programs.
|
|
| 2. |
- Haglund, Sofie, et al.
(author)
-
Differences in Whole-Blood Transcriptional Profiles in Inflammatory Bowel Disease Patients Responding to Vedolizumab Compared with Non-Responders
- 2023
-
In: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 24:6
-
Journal article (peer-reviewed)abstract
- Vedolizumab is efficacious in the treatment of Crohns disease (CD) and ulcerative colitis (UC). However, a significant proportion of patients present with a non-response. To investigate whether differences in the clinical response to vedolizumab is reflected in changes in gene expression levels in whole blood, samples were collected at baseline before treatment, and at follow-up after 10-12 weeks. Whole genome transcriptional profiles were established by RNA sequencing. Before treatment, no differentially expressed genes were noted between responders (n = 9, UC 4, CD 5) and non-responders (n = 11, UC 3, CD 8). At follow-up, compared with baseline, responders displayed 201 differentially expressed genes, and 51 upregulated (e.g., translation initiation, mitochondrial translation, and peroxisomal membrane protein import) and 221 downregulated (e.g., Toll-like receptor activating cascades, and phagocytosis related) pathways. Twenty-two of the upregulated pathways in responders were instead downregulated in non-responders. The results correspond with a dampening of inflammatory activity in responders. Although considered a gut-specific drug, our study shows a considerable gene regulation in the blood of patients responding to vedolizumab. It also suggests that whole blood is not optimal for identifying predictive pre-treatment biomarkers based on individual genes. However, treatment outcomes may depend on several interacting genes, and our results indicate a possible potential of pathway analysis in predicting response to treatment, which merits further investigation.
|
|
| 3. |
- Haglund, Sven, et al.
(author)
-
Sintering of WC-Co Under Axial Load
- 2021
-
In: International Journal of Materials Research - Zeitschrift für Metallkunde. - : WALTER DE GRUYTER GMBH. - 1862-5282 .- 2195-8556. ; 89:5, s. 323-326
-
Journal article (peer-reviewed)abstract
- Solid state sintering of cemented carbides is studied experimentally by means of dilatometry. Both an ordinary dilatometer and a dilatometer where an axial load was applied on the specimen were used. It is concluded that increased axial load, due to its hydrostatic component, gives larger volumetric shrinkage and that the decrease in the shrinkage rate at isothermal treatment is a result of a rapidly increasing rigidity of the powder compact at isothermal temperatures.
|
|
| 4. |
- Haglund, Sven, et al.
(author)
-
Solid State Sintering of Cemented Carbides - An Experimental Study
- 2021
-
In: International Journal of Materials Research - Zeitschrift für Metallkunde. - : WALTER DE GRUYTER GMBH. - 1862-5282 .- 2195-8556. ; 89:5, s. 316-322
-
Journal article (peer-reviewed)abstract
- Solid state sintering of cemented carbides is studied experimentally by means of dilatometry and SEM. Surface analysis of the powders is performed by means of ESCA, Auger and SIMS. It is concluded that for pure WC-Co mixtures the major part of densification occurs in the solid state and that high heating rates yield higher densification rates. 200 ppm of Ti, preferentially located at grain surfaces, yield a drastic decrease in sintering rate. Melting of the binder, i. e. transition to liquid phase sintering, only has a minor effect on densification rate.
|
|
| 5. |
- Kohne, Thomas, 1990-, et al.
(author)
-
Impact of Cooling Rate during High-Pressure Gas Quenching on Fatigue Performance of Low Pressure Carburized Gears
- 2022
-
In: Metals. - : MDPI AG. - 2075-4701. ; 12:11, s. 1917-1917
-
Journal article (peer-reviewed)abstract
- The impact of cooling rate during high-pressure gas quenching on the fatigue performance of low-pressure carburized spur gears was studied for steel grades 20MnCr5 and 17NiCrMo6-4. The results show an increased fatigue limit by 10 to 11% when applying a slower cooling rate for both steel grades. Moreover, for 20MnCr5 the slower cooled gears show an increase in compressive residual stresses by 130 MPa compared to the faster cooling, although no significant difference was observed for 17NiCrMo6-4. It is also seen that the cooling rate affects the core hardness for both steel grades, while other properties like surface hardness, case-hardness depth and martensite variant pairing were unaffected. The results for the retained austenite content and average martensite unit size show no clear effect of the cooling rate. The possible influence of different carbon distributions after quenching for the two used cooling rates on the carbide precipitation and fatigue limit is discussed. View Full-Text
|
|
