| 1. |
- Börjesson, Maria, 1974-, et al.
(author)
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Factors driving public support for road congestion reduction policies : Congestion charging, free public transport and more roads in Stockholm, Helsinki and Lyon
- 2015
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In: Transportation Research Part A. - : Elsevier BV. - 0965-8564 .- 1879-2375. ; 78, s. 452-462
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Journal article (peer-reviewed)abstract
- Based on an across-the-board survey conducted among residents of Stockholm, Helsinki and Lyon, we explore the opinions on three policy measures to combat road congestion: congestion charging, free public transport and building more roads. The support for the two latter policies is substantially higher than the support for congestion charging, which is only supported by a majority in Stockholm. Self-interest is important for the formation of the opinion to all three policies. However, fundamental values and general political views, indicated by four attitudinal factors, are even more important in forming opinions towards the three transport policies. Of all attitudinal factors, the one indicating environmental concern most influences the support for all policies. Equity concerns, however, increase the support for free public transport and opposition to taxation increases the support for building more roads. Our results further suggest that the opinions towards free public transport and building more roads can be mapped along the left right political axis, where Environment and Equity are to the left and Pricing and Taxation are to the right. However, the opinion towards congestion charging cuts right through the political spectrum. The impact of the fundamental values and self-interest variables are similar for Stockholm and Helsinki, indicating that even if experience increases the overall support for charging, it does not change the relative strength of different political arguments to any major extent.
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| 2. |
- Börjesson, Maria, 1974-, et al.
(author)
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Why experience changes attitudes to congestion pricing : The case of Gothenburg
- 2016
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In: Transportation Research Part A. - : Elsevier. - 0965-8564 .- 1879-2375. ; 85, s. 1-16
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Journal article (peer-reviewed)abstract
- Many cities have seen public support for congestion charges increase substantially after charges have been introduced. Several alternative explanations of this phenomenon have been suggested, but so far little evidence has been available to assess the relative importance of these explanations. We study attitudes to congestion pricing in Gothenburg before and after congestion charges were introduced in January 2013. Attitudes to the charges did indeed become more positive after the introduction, just as in previous cities. Using a two-wave postal survey, we separate contributions to the attitude change from a number of sources: benefits and costs being different than anticipated, use of hypothecated revenues, reframing processes, and changes in related attitudes such as attitudes to environment, equity, taxation and pricing measures in general. We conclude that the dominant reason for the attitude change is status quo bias, rather than any substantial changes in beliefs or related attitudes, although some of these factors also contribute. Contrary to a common belief, nothing of the attitude change is due to benefits being larger than anticipated.
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| 3. |
- Chhabra, Saurabh, et al.
(author)
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Myeloablative vs reduced-intensity conditioning allogeneic hematopoietic cell transplantation for chronic myeloid leukemia
- 2018
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In: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 2:21, s. 2922-2936
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Journal article (peer-reviewed)abstract
- Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment of chronic myeloid leukemia (CML). Optimal conditioning intensity for allo-HCT for CML in the era of tyrosine kinase inhibitors (TKIs) is unknown. Using the Center for International Blood and Marrow Transplant Research database, we sought to determine whether reduced-intensity/nonmyeloablative conditioning (RIC) allo-HCT and myeloablative conditioning (MAC) result in similar outcomes in CML patients. We evaluated 1395 CML allo-HCT recipients between the ages of 18 and 60 years. The disease status at transplant was divided into the following categories: chronic phase 1, chronic phase 2 or greater, and accelerated phase. Patients in blast phase at transplant and alternative donor transplants were excluded. The primary outcome was overall survival (OS) after allo-HCT. MAC (n = 1204) and RIC allo-HCT recipients (n = 191) from 2007 to 2014 were included. Patient, disease, and transplantation characteristics were similar, with a few exceptions. Multivariable analysis showed no significant difference in OS between MAC and RIC groups. In addition, leukemia-free survival and nonrelapse mortality did not differ significantly between the 2 groups. Compared with MAC, the RIC group had a higher risk of early relapse after allo-HCT (hazard ratio [HR], 1.85; P = .001). The cumulative incidence of chronic graft-versus-host disease (cGVHD) was lower with RIC than with MAC (HR, 0.77; P = .02). RIC provides similar survival and lower cGVHD compared with MAC and therefore may be a reasonable alternative to MAC for CML patients in the TKI era.
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| 4. |
- Jang, Kyung-Jin, et al.
(author)
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Reproducing human and cross-species drug toxicities using a Liver-Chip
- 2019
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In: Science Translational Medicine. - : AMER ASSOC ADVANCEMENT SCIENCE. - 1946-6234 .- 1946-6242. ; 11:517
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Journal article (peer-reviewed)abstract
- Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in the clinic. Here, we applied microengineered Organs-on-Chips technology to design a rat, dog, and human Liver-Chip containing species-specific primary hepatocytes interfaced with liver sinusoidal endothelial cells, with or without Kupffer cells and hepatic stellate cells, cultured under physiological fluid flow. The Liver-Chip detected diverse phenotypes of liver toxicity, including hepatocellular injury, steatosis, cholestasis, and fibrosis, and species-specific toxicities when treated with tool compounds. A multispecies Liver-Chip may provide a useful platform for prediction of liver toxicity and inform human relevance of liver toxicities detected in animal studies to better determine safety and human risk.
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| 5. |
- Joffrin, E., et al.
(author)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Research review (peer-reviewed)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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| 6. |
- Jonsson, Linda S., 1975-
(author)
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Online Sexual Behaviours Among Swedish Youth : Characteristics, Associations and Consequences
- 2015
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Doctoral thesis (other academic/artistic)abstract
- Online sexual behaviours refer to sexual activities where the Internet and/or mobile phone are used. The aims of this thesis were to investigate young people and their experiences of different online sexual behaviours with regard to characteristics, associations and consequences, by using data from a representative sample of 3,503 Swedish youth (m= 18.3 years). In addition 16 interviews were made with young women who had sold sex online before the age of 18. Focus in these interviews were in which ways contacts between buyer and seller were established and the motivational factors for selling sex online.In study I (n= 3,288), 20.9% (19.2% boys and 22.3% girls) reported experiences of voluntary online sexual exposure: flashing in webcam/mobile; posted partially undressed pictures or films; masturbated on webcam; had sex on webcam. Multivariate analysis showed a significant association between voluntary online sexual exposure and a number of different forms of harassments online. Neither poorer psychological health nor problematic relations with parents remained significant in the final model predicting voluntary online sexual exposure. In study II (n= 3,432) four online sexual behaviours were studied: meeting a person online for sex online; meeting a person online for sex offline; posted sexual pictures online; selling sex online. These were investigated in relation to socio-demographic factors, psychosocial wellbeing and risk behaviours. Bivariate logistic regressions were followed by multiple logistic regressions. The data suggested that most Swedish youth do not perform any of the assessed online sexual behaviours, but those who did (15.2%) reported a more problematic background, rated their health as poorer, had a more sexualised life and had experienced more sexual or physical abuse. This was especially prevalent among those who had sold sex online. In study III, young women with experiences of selling sex online before the age of 18 were interviewed. The interviews focused on the role Internet and mobile phone play and the methods of contacts and characteristics of the communication between buyer and seller. Two main themes were identified: Internet use - part of daily life for good and bad, depending on mood; Patterns of contacts - innocent/curious, dating, advertising. In the fourth study the interviews with the young women who had sold sex online before the age of 18 were analysed focusing on the women’s perceptions of the reasons why they started, continued and stopped selling sex. Three themes and eight sub-themes were identified in relation to different stages in their lives in the sex trade, each with its own storyline: Entering, adverse life experiences - traumatic events, feeling different and being excluded; Immersion, using the body as a regulating tool - being seen, being touched, being in control, affect regulation and self-harming; Exiting, change or die - living close to death, the process of quitting.In conclusion, the results from this thesis showed that most young people use Internet and mobile phones for non-sexual activities. Sexual behaviours online were associated with a more problematic background and poorer wellbeing. More research, attention and support are needed, especially related to young people selling sex online.
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| 7. |
- Souche-Le Corvec, Stephanie, et al.
(author)
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Predicting the results of a referendum on urban road pricing in France : "the cry of Cassandra"?
- 2016
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In: European Transport Research Review. - : Springer Berlin/Heidelberg. - 1867-0717 .- 1866-8887. ; 8:2
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Journal article (peer-reviewed)abstract
- Introduction Abundant literature now exists on the acceptability of the new pricing measure represented by urban tolls. However, this literature contains few examples providing a "political" analysis of their introduction. Here, our aim is to study how the political behavior of individuals, identified on the basis of general attitudes regarding the principles of regulation and pricing, influences, or does not influence, attitudes with respect to urban tolls. Method We study the ex-ante determinants of a vote on urban tolls. We use the results of a survey performed in France in the framework of the European Project ExpAcc (Explanatory Factors of Road User Charging Acceptability). We process the data using a Principal Components Analysis (PCA) then perform ordered logit estimation. Result Regarding the specific question to the referendum, we show that it would be rejected by electors. We also show that there is a significant link between general attitudes to regulation by legislation, tax or pricing policies in transport on the one hand, and the vote in the referendum on tolls on the other. We confirm that individual self-interest matters a lot in political behaviour but that other types of motives also matter strongly Conclusion As a consequence, a real-life political analysis cannot be limited to classical "economic" variables, even if they matter too obviously. Lastly, our results should be placed in relation with those concerning the more global issue of the acceptability of a new pricing measure through, for example, that of the compensation to be implemented.
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| 8. |
- Traylor, Matthew, et al.
(author)
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Genetic Variation at 16q24.2 is associated with small vessel stroke.
- 2017
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In: Annals of neurology. - : Wiley. - 1531-8249 .- 0364-5134. ; 81:3, s. 383-394
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Journal article (peer-reviewed)abstract
- Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises a quarter of all ischaemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown younger onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS meta-analysis, including a large younger onset SVS population, to identify novel associations with stroke.We used a three-stage age-at-onset informed GWAS to identify novel genetic variants associated with stroke. On identifying a novel locus associated with SVS, we assessed its influence on other small vessel disease phenotypes, as well as on mRNA expression of nearby genes, and on DNA methylation of nearby CpG sites in whole blood and in the fetal brain.We identified an association with SVS in 4,203 cases and 50,728 controls on chromosome 16q24.2 (OR(95% CI)=1.16(1.10-1.22); p=3.2x10(-9) ). The lead SNP (rs12445022) was also associated with cerebral white matter hyperintensities (OR(95% CI)=1.10(1.05-1.16); p=5.3x10(-5) ; N=3,670), but not intracerebral haemorrhage (OR(95% CI)=0.97(0.84-1.12); p=0.71; 1,545 cases, 1,481 controls). rs12445022 is associated with mRNA expression of ZCCHC14 in arterial tissues (p=9.4x10(-7) ), and DNA methylation at probe cg16596957 in whole blood (p=5.3x10(-6) ).16q24.2 is associated with SVS. Associations of the locus with expression of ZCCHC14 and DNA methylation suggest the locus acts through changes to regulatory elements. This article is protected by copyright. All rights reserved.
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