1. |
|
|
2. |
|
|
3. |
|
|
4. |
|
|
5. |
- Kowalec, K, et al.
(author)
-
Methylation age acceleration does not predict mortality in schizophrenia
- 2019
-
In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 9:1, s. 157-
-
Journal article (peer-reviewed)abstract
- Schizophrenia (SCZ) is associated with high mortality. DNA methylation levels vary over the life course, and pre-selected combinations of methylation array probes can be used to estimate “methylation age” (mAge). mAge correlates highly with chronological age but when it differs, termed mAge acceleration, it has been previously associated with all-cause mortality. We tested the association between mAge acceleration and mortality in SCZ and controls. We selected 190 SCZ cases and 190 controls from the Sweden Schizophrenia Study. Cases were identified from the Swedish Hospital Discharge Register with ≥5 specialist treatment contacts and ≥5 antipsychotic prescriptions. Controls had no psychotic disorder or antipsychotics. Subjects were selected if they had died or survived during follow-up (2:1 oversampling). Extracted DNA was assayed on the Illumina MethylationEPIC array. mAge was regressed on age at sampling to obtain mAge acceleration. Using Cox proportional hazards regression, the association between mAge acceleration and mortality was tested. After quality control, the following were available: n = 126 SCZ died, 63 SCZ alive, 127 controls died, 62 controls alive. In the primary analyses, we did not find a significant association between mAge acceleration and SCZ mortality (adjusted p > 0.005). Sensitivity analyses excluding SCZ cases with pre-existing cancer demonstrated a significant association between the Hannum mAge acceleration and mortality (hazard ratio = 1.13, 95% confidence interval = 1.04–1.22, p = 0.005). Per our pre-specified criteria, we did not confirm our primary hypothesis that mAge acceleration would predict subsequent mortality in people with SCZ, but we cannot rule out smaller effects or effects in patient subsets.
|
|
6. |
|
|
7. |
- Wastegård, Stefan, et al.
(author)
-
Towards a Holocene tephrochronology for the Faroe Islands, North Atlantic
- 2018
-
In: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 195, s. 195-214
-
Journal article (peer-reviewed)abstract
- The Faroe Islands hold a key position in the North Atlantic region for tephra studies due to their relative proximity to Iceland. Several tephras have been described over the last 50 years in peat and lake sediment sequences, including the type sites for the Saksunarvatn and Mjauvotn tephras. Here we present a comprehensive overview of Holocene tephras found on the Faroe Island. In total 23 tephra layers are described including visible macrotephras such as the Saksunarvatn and Hekla 4 tephras and several cryptotephras. The importance of tephras originally described from the Faroe Islands is highlighted and previously unpublished results are included. In addition, full datasets for several sites are published here for the first time. The Saksunarvatn Ash, now considered to be the result of several eruptions rather than one major eruption, can be separated into two phases on the Faroe Islands; one early phase with two precursor eruptions with lower MgO concentrations (4.5-5.0 wt%) than the main eruption and a later phase with higher MgO concentrations (5.5-6.0 wt%), including the visible Saksunarvatn Ash. The Tjornuvik Tephra, previously considered to be a primary deposit, is now interpreted as a reworked tephra with material from at least two middle Holocene eruptions of Hekla. Several of the tephras identified on the Faroe Islands provide useful isochrons for climate events during the Holocene.
|
|