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- Josephson, Olle, 1950-
(author)
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Åtta sätt att skriva kort och effektivt
- 2012
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In: Språktidningen. - Stockholm : Språktidningen i Sverige AB. - 1654-5028. ; :6, s. 48-49
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Journal article (pop. science, debate, etc.)
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- Smith, Cory J., et al.
(author)
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Enabling large-scale genome editing at repetitive elements by reducing DNA nicking
- 2020
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In: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 48:9, s. 5183-5195
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Journal article (peer-reviewed)abstract
- To extend the frontier of genome editing and enable editing of repetitive elements of mammalian genomes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of thousands of loci per cell by overcoming the cell death associated with DNA double-strand breaks and single-strand breaks. We used a set of gRNAs targeting repetitive elements-ranging in target copy number from about 32 to 161 000 per cell. dBEs enabled survival after large-scale base editing, allowing targeted mutations at up to ∼13 200 and ∼12 200 loci in 293T and human induced pluripotent stem cells (hiPSCs), respectively, three orders of magnitude greater than previously recorded. These dBEs can overcome current on-target mutation and toxicity barriers that prevent cell survival after large-scale genome engineering.
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- Abelev, B., et al.
(author)
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Light vector meson production in pp collisions at root s=7 TeV ALICE Collaboration
- 2012
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In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 710:4-5, s. 557-568
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Journal article (peer-reviewed)abstract
- The ALICE experiment has measured low-mass dimuon production in pp collisions at root s = 7 TeV in the dimuon rapidity region 2.5 < y < 4. The observed dimuon mass spectrum is described as a superposition of resonance decays (eta, rho, omega, eta', phi) into muons and semi-leptonic decays of charmed mesons. The measured production cross sections for omega and phi are sigma(omega)(1 < p(t) < 5 GeV/c. 2.5 < y < 4) = 5.28 +/- 0.54(stat) +/- 0.49(syst) mb and sigma(phi)(1 < p(t) < 5 GeV/c. 2.5 < y < 4) = 0.940 +/- 0.084(stat) +/- 0.076(syst) mb. The differential cross sections d(2)sigma/dy dp(t) are extracted as a function of p(t) for omega and phi. The ratio between the rho and omega cross section is obtained. Results for the phi are compared with other measurements at the same energy and with predictions by models. (C) 2012 CERN. Published by Elsevier B.V. All rights reserved.
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- Abelev, B., et al.
(author)
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Measurement of inelastic, single- and double-diffraction cross sections in proton-proton collisions at the LHC with ALICE
- 2013
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 73:6
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Journal article (peer-reviewed)abstract
- Measurements of cross sections of inelastic and diffractive processes in proton-proton collisions at LHC energies were carried out with the ALICE detector. The fractions of diffractive processes in inelastic collisions were determined from a study of gaps in charged particle pseudorapidity distributions: for single diffraction (diffractive mass M-X < 200 GeV/c(2)) sigma(SD)/sigma(INEL) = 0.21 +/- 0.03, 0.20(-0.08)(+0.07,) and 0.20(-0.07)(+0.04), respectively at centre-of-mass energies root s = 0.9, 2.76, and 7 TeV; for double diffraction (for a pseudorapidity gap Delta eta > 3) sigma(DD)/sigma(INEL) = 0.11 +/- 0.03, 0.12 +/- 0.05, and 0.12(-0.04)(+0.05), respectively at root s = 0.9, 2.76, and 7 TeV. To measure the inelastic cross section, beam properties were determined with van der Meer scans, and, using a simulation of diffraction adjusted to data, the following values were obtained: sigma(INEL) = 62.8(-4.0)(+2.4)(model) +/- 1.2(lumi) mb at root s = 2.76 TeV and 73.2(-4.6)(+2.0)(model) +/- 2.6(lumi) mb at root s = 7 TeV. The single- and double-diffractive cross sections were calculated combining relative rates of diffraction with inelastic cross sections. The results are compared to previous measurements at proton-antiproton and proton-proton colliders at lower energies, to measurements by other experiments at the LHC, and to theoretical models.
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