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Träfflista för sökning "WFRF:(Hartung A.) srt2:(2020-2023)"

Search: WFRF:(Hartung A.) > (2020-2023)

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  • Muller, S, et al. (author)
  • Target 2035 - update on the quest for a probe for every protein
  • 2022
  • In: RSC medicinal chemistry. - : Royal Society of Chemistry (RSC). - 2632-8682. ; 13:1, s. 13-21
  • Journal article (other academic/artistic)abstract
    • Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. Target 2035 aims to develop a pharmacological modulator for every protein in the human proteome to fill this gap.
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  • Jahnke, T., et al. (author)
  • Inner-Shell-Ionization-Induced Femtosecond Structural Dynamics of Water Molecules Imaged at an X-Ray Free-Electron Laser
  • 2021
  • In: Physical Review X. - : American Physical Society. - 2160-3308. ; 11:4
  • Journal article (peer-reviewed)abstract
    • The ultrafast structural dynamics of water following inner-shell ionization is a crucial issue in high-energy radiation chemistry. We have exposed isolated water molecules to a short x-ray pulse from a free-electron laser and detected momenta of all produced ions in coincidence. By combining experimental results and theoretical modeling, we can image dissociation dynamics of individual molecules in unprecedented detail. We reveal significant molecular structural dynamics in H2O2+, such as asymmetric deformation and bond-angle opening, leading to two-body or three-body fragmentation on a timescale of a few femtoseconds. We thus reconstruct several snapshots of structural dynamics at different time intervals, which highlight dynamical patterns that are relevant as initiating steps of subsequent radiation-damage processes.
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  • Ackloo, S, et al. (author)
  • Target 2035 - an update on private sector contributions
  • 2023
  • In: RSC medicinal chemistry. - : Royal Society of Chemistry (RSC). - 2632-8682. ; 14:6, s. 1002-1011
  • Journal article (other academic/artistic)abstract
    • Target 2035, an international federation of biomedical scientists from the public and private sectors, is leveraging ‘open’ principles to develop a pharmacological tool for every human protein.
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