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Träfflista för sökning "WFRF:(Hassinen M.) srt2:(2020-2024)"

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1.	Bogacheva, MS, et al. (author) Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome 2024 In: Antiviral research. - 1872-9096. ; 223, s. 105813- Journal article (peer-reviewed)
2.	Komulainen, P, et al. (author) Exercise, diet, and cognition in a 4-year randomized controlled trial: Dose-Responses to Exercise Training (DR's EXTRA) 2021 In: The American journal of clinical nutrition. - : Elsevier BV. - 1938-3207 .- 0002-9165. ; 113:6, s. 1428-1439 Journal article (peer-reviewed)
3.	Pietiäinen, V, et al. (author) Image-based and machine learning-guided multiplexed serology test for SARS-CoV-2 2023 In: Cell reports methods. - 2667-2375. ; 3:8, s. 100565- Journal article (peer-reviewed)
4.	Feodoroff, M, et al. (author) Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT) 2023 In: SLAS discovery : advancing life sciences R & D. - : Elsevier BV. - 2472-5560. ; 28:4, s. 138-148 Journal article (peer-reviewed)
5.	Feoforoff, M, et al. (author) Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT) 2023 In: SLAS discovery : advancing life sciences R & D. - : Elsevier BV. - 2472-5560. ; 28:4, s. 138-148 Journal article (peer-reviewed)
6.	Kuisma, H, et al. (author) Parity associates with chromosomal damage in uterine leiomyomas 2021 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 5448- Journal article (peer-reviewed)abstract Mechanical forces in a constrained cellular environment were recently established as a facilitator of chromosomal damage. Whether this could contribute to tumorigenesis is not known. Uterine leiomyomas are common neoplasms that display relatively few chromosomal aberrations. We hypothesized that if mechanical forces contribute to chromosomal damage, signs of this could be seen in uterine leiomyomas from parous women. We examined the karyotypes of 1946 tumors, and found a striking overrepresentation of chromosomal damage associated with parity. We then subjected myometrial cells to physiological forces similar to those encountered during pregnancy, and found this to cause DNA breaks and a DNA repair response. While mechanical forces acting in constrained cellular environments may thus contribute to neoplastic degeneration, and genesis of uterine leiomyoma, further studies are needed to prove possible causality of the observed association. No evidence for progression to malignancy was found.

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Result 1-6 of 6

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Type of publication: journal article (6)

Type of content: peer-reviewed (6)

Author/Editor: Hassinen, A (5); Kallioniemi, O (4); Potdar, S (4); Paavolainen, L (4); Turunen, L (4); Vapalahti, O. (2); show more...; Feodoroff, M (2); Pietiäinen, V (2); Pietiainen, V (2); Sjoberg, J (1); Butzow, R (1); Kivipelto, M (1); Kaasinen, E (1); Aaltonen, LA (1); Taipale, J (1); Horvath, P. (1); Hepojoki, J (1); Heikinheimo, O (1); Tuomilehto, J. (1); Pasanen, A. (1); Saarela, J. (1); Rauramaa, R (1); Lakka, TA (1); Kantele, A (1); Jalkanen, J (1); Savonen, K (1); Julkunen, I (1); Varjosalo, M (1); Kovacs, F (1); Komulainen, P (1); Heikkinen, S (1); Kuisma, H (1); Valimaki, N (1); Kaukomaa, J (1); Makinen, N (1); Rajamaki, K (1); Palin, K (1); Bogacheva, MS (1); Kuivanen, S (1); Huuskonen, S (1); Pohner, I (1); Luck, TJ (1); Szirovicza, L (1); Savijoki, K (1); Tammela, P (1); Poso, A (1); Murumagi, A (1); Fodor, E (1); Hanninen, T (1); Jacobs, DR (1); show less...

University: Karolinska Institutet (6)

Language: English (6)

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