| 1. |
- Daerga, L, et al.
(författare)
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Occupational musculoskeletal dysfunctions among reindeer herding Sami in Sweden
- 2006
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Ingår i: Vaartoe.
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Konferensbidrag (populärvet., debatt m.m.)abstract
- Objectives: In a previous pilot studies it was indicated that the prevalence of musculoskeletal pain (MSP) is high among reindeer herders. The main objective of the present study was to explore potential relations between self-reported MSP, perceived dysfunction and quality of life among Swedish reindeer herding Sami, with particular emphasis on gender comparisons. Study Design: Cross-sectional, semi-randomised, cohort study. Methods: A total of 154 reindeer herders (86 men, 68 women) were offered participation in the study. They were semi-randomly selected from 7 Sami communities and represented herders who were older than 18 years of age, and belonged to households where reindeer husbandry constituted a major source of income. They answered questionnaire on pain intensity, duration and frequency in 10 separate body regions, on functional disturbances (SF-36 and Neck Disability Index), and on quality of life (in four domains - physical, social, mental and health). The questionnaires were distributed via mail to complement clinical data acquired during health examination executed by physiotherapists and GPs. Results: Preliminary analyses revealed a high prevalence of MSP, particularly of the back, neck, shoulder, elbows and wrists, both among men and women. Significant functional impairments and poor quality of life were reported by a majority of the participants. Conclusions: Detailed results and general conclusions will be presented at the conference
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| 2. |
- Edin-Liljegren, A, et al.
(författare)
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Psychosocial risk factors among Sami in Sweden : a controlled cohort study
- 2006
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Ingår i: Vaartoe.
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Konferensbidrag (populärvet., debatt m.m.)abstract
- Objective: To investigate the occurrence of psychosocial, clinical and behavioural risk factors for cardiovascular diseases (CVD) among reindeer herding and non-reindeer herding Sami. The results on psychosocial risk factors are presented here. Materials and Methods: A cohort of 611 Swedish Sami (276 men and 335 women) was constructed from national population registers and compared with a twice as large control population of non-Sami, matched by age, gender and area of residency. Information on quality of life, social support and Karasek and Theorell`s job-strain indices was obtained from a database containing information from a regional CVD-preventive program. The data was collected from the period of 1990–2001. Results: The Sami people reported lower quality of life and higher demand and intellectual discretion at work than the non-Sami. The Sami women, the reindeer herding as well as the non-reindeer herding, had lower scores on intellectual discretion and social support at work compared with the Sami men. Conclusions: Regarding the psychosocial risk factors investigated here it seems that the Sami women are at higher risk than the Sami men.
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| 3. |
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| 4. |
- Leutenegger, M., et al.
(författare)
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Single molecule detection at surfaces : Dual-color fluorescence fluctuation spectroscopy with total internal reflection excitation
- 2007
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Ingår i: New Approaches in Biomedical Spectroscopy. - Washington, DC : American Chemical Society (ACS). - 0841274371 - 9780841274372 ; , s. 259-279
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Konferensbidrag (refereegranskat)abstract
- Fluorescence fluctuation spectroscopy based on an evanescent field excitation scheme leads to an alternative concept for single molecule detection with interesting experimental features. This concept is described and analyzed regarding the total fluorescence process including excitation, fluorescence emission and collection close to a dielectric interface. The realized experimental scheme showed superior performance of this concept with substantially enhanced molecular brightness when compared to the classical confocal setup based on water immersion objectives. Selected applications in life sciences including dual-color surface fluorescence correlation spectroscopy, enzyme kinetics and receptor-ligand binding are underlining the interest of this experimental approach.
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| 5. |
- Siller, Maria, et al.
(författare)
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Functional analysis of the group A streptococcal luxS/AI-2 system in metabolism, adaptation to stress and interaction with host cells
- 2008
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Ingår i: BMC Microbiology. - : BioMed Central. - 1471-2180. ; 8, s. 188-
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Tidskriftsartikel (refereegranskat)abstract
- Background The luxS/AI-2 signaling pathway has been reported to interfere with important physiological and pathogenic functions in a variety of bacteria. In the present study, we investigated the functional role of the streptococcal luxS/AI-2 system in metabolism and diverse aspects of pathogenicity including the adaptation of the organism to stress conditions using two serotypes of Streptococcus pyogenes, M1 and M19. Results Exposing wild-type and isogenic luxS-deficient strains to sulfur-limited media suggested a limited role for luxS in streptococcal activated methyl cycle metabolism. Interestingly, loss of luxS led to an increased acid tolerance in both serotypes. Accordingly, luxS expression and AI-2 production were reduced at lower pH, thus linking the luxS/AI-2 system to stress adaptation in S. pyogenes. luxS expression and AI-2 production also decreased when cells were grown in RPMI medium supplemented with 10% serum, considered to be a host environment-mimicking medium. Furthermore, interaction analysis with epithelial cells and macrophages showed a clear advantage of the luxS-deficient mutants to be internalized and survive intracellularly in the host cells compared to the wild-type parents. In addition, our data revealed that luxS influences the expression of two virulence-associated factors, the fasX regulatory RNA and the virulence gene sibA (psp). Conclusion Here, we suggest that the group A streptococcal luxS/AI-2 system is not only involved in the regulation of virulence factor expression but in addition low level of luxS expression seems to provide an advantage for bacterial survival in conditions that can be encountered during infections.
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