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Träfflista för sökning "WFRF:(Hautaniemi S) srt2:(2015-2019)"

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Result 1-8 of 8

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1.	Kondelin, J, et al. (author) Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer 2018 In: EMBO molecular medicine. - : EMBO. - 1757-4684 .- 1757-4676. ; 10:9 Journal article (peer-reviewed)
2.	Pekkonen, P, et al. (author) Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation 2018 In: eLife. - 2050-084X. ; 7 Journal article (peer-reviewed)
3.	Pulkka, OP, et al. (author) Anagrelide for Gastrointestinal Stromal Tumor 2019 In: Clinical cancer research : an official journal of the American Association for Cancer Research. - 1557-3265. ; 25:5, s. 1676-1687 Journal article (peer-reviewed)
4.	Tumiati, M, et al. (author) A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients 2018 In: Clinical cancer research : an official journal of the American Association for Cancer Research. - 1557-3265. ; 24:18, s. 4482-4493 Journal article (peer-reviewed)
5.	Tumiati, M, et al. (author) A FUNCTIONAL HOMOLOGOUS RECOMBINATION ASSAY PREDICTS PRIMARY CHEMOTHERAPY RESPONSE AND LONG-TERM SURVIVAL IN OVARIAN CANCER PATIENTS 2019 In: CLINICAL CANCER RESEARCH. - 1078-0432. ; 25:22, s. 120-120 Conference paper (other academic/artistic)
6.	Balistreri, G, et al. (author) Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication 2016 In: PLoS pathogens. - : Public Library of Science (PLoS). - 1553-7374. ; 12:2, s. e1005424- Journal article (peer-reviewed)
7.	Ullah, I., et al. (author) Evolutionary analyses of matched primary and metastatic breast cancer reveal both linear and parallel progression with lack of axillary lymph node involvement 2017 In: Cancer Research. - : American Association for Cancer Research (AACR). - 0008-5472 .- 1538-7445. ; 77 Journal article (other academic/artistic)
8.	Ullah, I., et al. (author) Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes 2018 In: Journal of Clinical Investigation. - : American Society for Clinical Investigation. - 0021-9738 .- 1558-8238. ; 128:4, s. 1355-1370 Journal article (peer-reviewed)abstract Metastatic breast cancers are still incurable. Characterizing the evolutionary landscape of these cancers, including the role of metastatic axillary lymph nodes (ALNs) in seeding distant organ metastasis, can provide a rational basis for effective treatments. Here, we have described the genomic analyses of the primary tumors and metastatic lesions from 99 samples obtained from 20 patients with breast cancer. Our evolutionary analyses revealed diverse spreading and seeding patterns that govern tumor progression. Although linear evolution to successive metastatic sites was common, parallel evolution from the primary tumor to multiple distant sites was also evident. Metastatic spreading was frequently coupled with polyclonal seeding, in which multiple metastatic subclones originated from the primary tumor and/or other distant metastases. Synchronous ALN metastasis, a well-established prognosticator of breast cancer, was not involved in seeding the distant metastasis, suggesting a hematogenous route for cancer dissemination. Clonal evolution coincided frequently with emerging driver alterations and evolving mutational processes, notably an increase in apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like-associated (APOBEC-associated) mutagenesis. Our data provide genomic evidence for a role of ALN metastasis in seeding distant organ metastasis and elucidate the evolving mutational landscape during cancer progression.

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Result 1-8 of 8

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Type of publication: journal article (7); conference paper (1)

Type of content: peer-reviewed (6); other academic/artistic (2)

Author/Editor: Hautaniemi, S (6); Lehtonen, R (3); Lehti, K (3); Varjosalo, M (3); Kallioniemi, O (2); Bergh, J (2); show more...; Li, YL (2); Taipale, J (2); Pekkonen, P (2); Ojala, PM (2); Ullah, I (2); Hartman, J (2); Icay, K (2); Balistreri, G (2); Turunen, M (2); Liu, X (1); Mpindi, JP (1); Joensuu, H (1); Diaz, R. (1); Aavikko, M (1); Kaasinen, E (1); Aaltonen, LA (1); Vahteristo, P (1); Taipale, M (1); Lagergren, J (1); Cervera, A. (1); Lagergren, Jens (1); Laaksonen, M (1); Wennerberg, K (1); Sihto, H. (1); Lepistö, A. (1); Rantala, J. (1); Stalhammar, G (1); Stålhammar, G (1); Böhm, J. (1); Viiliainen, J (1); Lyly, L (1); Ojala, K (1); Sarek, G (1); Teesalu, M (1); Denisova, O (1); Peltonen, K (1); Julkunen, I (1); Kainov, D (1); Laiho, M (1); Karhu, A (1); Cajuso, T (1); Palin, K (1); Taiwo, A (1); Schoffski, P. (1); show less...

University: Karolinska Institutet (8); Royal Institute of Technology (2)

Language: English (8)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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