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- Hedlund, Petter, et al.
(author)
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Effects of nicorandil on human isolated corpus cavernosum and cavernous artery
- 1994
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In: Journal of Urology. - : Elsevier. - 0022-5347 .- 1527-3792. ; 151:4, s. 1107-1113
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Journal article (peer-reviewed)abstract
- Nitric oxide (NO) released from nonadrenergic-noncholinergic (NANC) nerves seems to be a principal mediator of the relaxation of penile erectile tissue necessary for erection, and drugs acting by release of NO have been shown to produce erection when injected intracorporeally into impotent patients. By producing hyperpolarization, K+ channel openers are effective in relaxing isolated penile erectile tissue from rabbit and man, and can produce tumescence and erection when injected intracorporeally into animals. Nicorandil is classified as a K+ channel opener, but it also acts as a donor of NO. In the present study, the effects of nicorandil on isolated preparations from human corpus cavernosum (CC) and deep cavernous artery (Acc) were compared with those of cromakalim (K+ channel opener) and SIN-1 (NO donor). Nicorandil produced a concentration-dependent relaxation of CC and Acc preparations. The relaxations obtained at the highest nicorandil concentration used (10(-4) M.) were 75 +/- 3% and 66 +/- 4% in CC preparations contracted by noradrenaline and endothelin-1, respectively. The corresponding effects in Acc preparations were 70 +/- 14% and 73 +/- 5%. Glibenclamide (blocking ATP-dependent K+ channels) significantly reduced the nicorandil-induced relaxation in CC, but not in Acc. Methylene blue (believed to block soluble guanylate cyclase) reduced nicorandil's relaxant effect in CC, although statistical significance was not obtained. NG-nitro-L-arginine 10(-4) M. (NO synthase inhibitor) did not significantly influence the effect of nicorandil on precontracted preparations in either tissue. In CC preparations contracted by electrical field stimulation, nicorandil and cromakalim concentration dependently inhibited the responses. This effect was significantly counteracted by glibenclamide. It is concluded that nicorandil is effective in relaxing human CC chiefly by its K+ channel opening action, and to some extent by its ability to release NO. For nicorandil's relaxing effect on Acc, ATP dependent K+ channels seem to be of limited importance. If effective in impotent patients, the drug may represent a new, interesting approach to the treatment of erectile dysfunction.
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| 2. |
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| 3. |
- Hedlund, Christer, 1964-, et al.
(author)
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Microloading effect in reactive ion etching
- 1994
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In: Journal of Vacuum Science & Technology. A. Vacuum, Surfaces, and Films. - : American Vacuum Society. - 0734-2101 .- 1520-8559. ; 12:4, s. 1962-1965
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Journal article (peer-reviewed)abstract
- The etch rate of silicon, during reactive ion etching (RIE), depends on the total exposed area. This is called the loading effect. However, local variations in the pattern density will, in a similar way, cause local variations in the etch rate. This effect is caused by a local depletion of reactive species and is called the microloading effect. Silicon wafers patterned with silicon dioxide have been etched in order to study the microloading effect. The pattern consists of a large exposed area and narrow lines at different distances from the edge of the large area. This arrangement makes it possible to study how the distance from the large area, which depletes the etchants, influences the etch rate. The influence of different processing parameters like, e.g., pressure, gas flow rate, and flow direction on the microloading effect have been investigated. It has been found that the microloading effect is small (<10%) compared to other pattern dependent nonuniformities. It is also shown that the nonuniformities caused by the microloading effect can be decreased by, e.g., decreasing the pressure or increasing the gas flow rate.
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| 4. |
- Hedlund, K., et al.
(author)
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Mate choice and male competition in Orchesella cincta (Collembola)
- 1990
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In: Experientia. - 0014-4754. ; 46:5, s. 524-526
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Journal article (peer-reviewed)abstract
- Both male and female Orchesella cincta (Collembola) were able to discriminate between spermatophores of different origin. Females chose spermatophores deposited by closely related males while males preferentially destroyed spermatophores of other males.
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