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- Watson, H. J., et al.
(author)
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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
- 2019
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 51:8
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Journal article (peer-reviewed)abstract
- Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness(1), affecting 0.9-4% of women and 0.3% of men(2-4), with twin-based heritability estimates of 50-60%(5). Mortality rates are higher than those in other psychiatric disorders(6), and outcomes are unacceptably poor(7). Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)(8,9) and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
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- Cibecchini, Daniele, et al.
(author)
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Repairing of a timber truss through two different techniques using timber elements and screwed metal plates
- 2015
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In: Historical Earthquake-Resistant Timber Framing in the Mediterranean Area. - Cham : Springer International Publishing. - 9783319394916 - 9783319394923 ; , s. 371-381
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Conference paper (peer-reviewed)abstract
- Structural reinforcement of timber buildings may be needed due to different reasons such as change of use, deterioration, lack of maintenance, exceptional damaging incidents or loading, to comply with regulatory changes and being retrofitted, or interventions to increase structural resistance.In this work, two different techniques were considered for repair of a timber truss, subjected only to vertical loads, that was previously assessed on laboratory (test facilities of University of Minho) and taken up to failure during a load-carrying test. A collar beam truss, with more than one hundred years, was tested carrying a vertical point load on each main rafter. Failure of the timber truss was located in the sections of the rafters near the loading positions by bending.Repairing techniques, based on the use of timber elements for one of the rafters and on screwed metal plates for the other rafter, were evaluated and compared to the original unstrengthened condition. The efficiency of the combined repairing techniques was evaluated taking into consideration the structural performance of the collar truss, namely its displacement and ultimate load capacity.In this paper, the results of the experimental tests are discussed attending to the analytical calculation of the contribution of the repairing techniques. Also, the different failure scenarios, for original and strengthened truss, were analyzed and compared.
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