| 1. |
- Albrecht, Eva, et al.
(author)
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Telomere length in circulating leukocytes is associated with lung function and disease
- 2014
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In: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 43:4, s. 983-992
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Journal article (peer-reviewed)abstract
- Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and spirometric parameters (forced expiratory volume in is (FEV1), forced vital capacity (PVC) and FEV1/FVC) of 12 595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex and smoking status. We observed negative associations between telomere length and asthma (beta= -0.0452, p= 0.024) as well as COPD (beta= -0.0982, p=0.001), with associations being stronger and more significant when using GLI criteria than those of GOLD. In both diseases, effects were stronger in females than males. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p=1.07 x 10(-7)), FVC (p=2.07 x 10(-5)), and FEV1/FVC (p =5.27 x 10(-3)). The effect was somewhat weaker in apparently healthy subjects than in COPD or asthma patients. Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases.
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| 2. |
- Björk, Göran, 1956, et al.
(author)
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Flow of Canadian Basin Deep Water in the Western Eurasian Basin of the Arctic Ocean
- 2010
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In: Deep Sea Research. - : Elsevier BV. - 0967-0637 .- 1879-0119. ; 57:4, s. 577-586
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Journal article (peer-reviewed)abstract
- The LOMROG 2007 expedition targeted the previously unexplored southern part of the Lomonosov Ridge north of Greenland together with a section from the Morris Jesup Rise to Gakkel Ridge. The oceanographic data shows that Canadian Basin Deep Water (CBDW) passes the Lomonosov Ridge in the area of the Intra Basin close to the North Pole and then continues along the ridge towards Greenland and further along its northernmost continental slope. The CBDW is clearly evident as a salinity maximum and oxygen minimum at a depth of about 2000 m. The cross slope sections at the Amundsen Basin side of the Lomonosov Ridge and further south at the Morris Jesup Rise show a sharp frontal structure higher up in the water column between Makarov Basin water and Amundsen Basin water. The frontal structure continues upward into the Atlantic Water up to a depth of about 300 m. The observed water mass division at levels well above the ridge crest indicates a strong topographic steering of the flow and that different water masses tend to pass the ridge guided by ridge-crossing isobaths at local topographic heights and depressions. A rough scaling analysis shows that the extremely steep and sharply turning bathymetry of the Morris Jesup Rise may force the boundary current to separate and generate deep eddies.
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| 3. |
- Dowdeswell, J. A., et al.
(author)
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High-resolution geophysical observations of the Yermak Plateau and northern Svalbard margin : Implications for ice-sheet grounding and deep-keeled icebergs
- 2010
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In: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 29:25-26, s. 3518-3531
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Journal article (peer-reviewed)abstract
- High-resolution geophysical evidence on the seafloor morphology and acoustic stratigraphy of the Yermak Plateau and northern Svalbard margin between 79°20′ and 81°30′N and 5° and 22°E is presented. Geophysical datasets are derived from swath bathymetry and sub-bottom acoustic profiling and are combined with existing cores to derive chronological control. Seafloor landforms, in the form of ice-produced lineations, iceberg ploughmarks of various dimensions (including features over 80 m deep and down to about 1000 m), and a moat indicating strong currents are found. The shallow stratigraphy of the Yermak Plateau shows three acoustic units: the first with well-developed stratification produced by hemipelagic sedimentation, often draped over a strong and undulating internal reflector; a second with an undulating upper surface and little acoustic penetration, indicative of the action of ice; a third unit of an acoustically transparent facies, resulting from debris flows. Core chronology suggests a MIS 6 age for the undulating seafloor above about 580 m. There are several possible explanations, including: (a) the flow of a major grounded ice sheet across the plateau crest from Svalbard (least likely given the consolidation state of the underlying sediments); (b) the more transient encroachment of relatively thin ice from Svalbard; or (c) the drift across the plateau of an ice-shelf remnant or megaberg from the Arctic Basin. The latter is our favoured explanation given the evidence currently at our disposal.
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| 4. |
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| 5. |
- Jakobsson, Martin, et al.
(author)
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The International Bathymetric Chart of the Arctic Ocean (IBCAO) Version 3.0
- 2012
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In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 39
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Journal article (peer-reviewed)abstract
- The International Bathymetric Chart of the Arctic Ocean (IBCAO) released its first gridded bathymetric compilation in 1999. The IBCAO bathymetric portrayals have since supported a wide range of Arctic science activities, for example, by providing constraint for ocean circulation models and the means to define and formulate hypotheses about the geologic origin of Arctic undersea features. IBCAO Version 3.0 represents the largest improvement since 1999 taking advantage of new data sets collected by the circum-Arctic nations, opportunistic data collected from fishing vessels, data acquired from US Navy submarines and from research ships of various nations. Built using an improved gridding algorithm, this new grid is on a 500 meter spacing, revealing much greater details of the Arctic seafloor than IBCAO Version 1.0 (2.5 km) and Version 2.0 (2.0 km). The area covered by multibeam surveys has increased from similar to 6% in Version 2.0 to similar to 11% in Version 3.0. Citation: Jakobsson, M., et al. (2012), The International Bathymetric Chart of the Arctic Ocean (IBCAO) Version 3.0, Geophys. Res. Lett., 39, L12609, doi:10.1029/2012GL052219.
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| 6. |
- Jämthagen, Christopher, et al.
(author)
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eavesROP: Listening for ROP Payloads in Data Streams
- 2014
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In: Information Security/Lecture Notes in Computer Science. - Cham : Springer International Publishing. - 0302-9743. - 9783319132563 - 9783319132570 ; 8783, s. 413-424
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Conference paper (peer-reviewed)abstract
- We consider the problem of detecting exploits based on return-oriented programming. In contrast to previous works we investigate to which extent we can detect ROP payloads by only analysing streaming data, i.e., we do not assume any modifications to the target machine, its kernel or its libraries. Neither do we attempt to execute any potentially malicious code in order to determine if it is an attack. While such a scenario has its limitations, we show that using a layered approach with a filtering mechanism together with the Fast Fourier Transform, it is possible to detect ROP payloads even in the presence of noise and assuming that the target system employs ASLR. Our approach, denoted eavesROP, thus provides a very lightweight and easily deployable mitigation against certain ROP attacks. It also provides the added merit of detecting the presence of a brute-force attack on ASLR since library base addresses are not assumed to be known by eavesROP.
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| 7. |
- Linder, Astrid, et al.
(author)
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ADSEAT - Adaptive Seat to Reduce Neck Injuries for Female and Male Occupants
- 2013
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In: Accident Analysis and Prevention. - : Elsevier BV. - 0001-4575 .- 1879-2057. ; 60, s. 334-343
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Journal article (peer-reviewed)abstract
- Neck injuries sustained in low severity vehicle crashes are of worldwide concern and the risk is higher for females than for males. The objective of the study was to provide guidance on how to evaluate protective performance of vehicle seat designs aiming to reduce the incidence of neck injuries for female and male occupants. The objective was achieved by reviewing injury risk, establishing anthropometric data of an average female, performing dynamic volunteer tests comprising females and males, and developing a finite element model, EvaRID, of an average female. With respect to injury criteria, it was concluded based on the tests that using NIC (with a lower threshold value) and Nkm (with reduced intercept values) for females would be a suitable starting point. Virtual impact simulations with seats showed that differences were found in the response of the BioRID II and EvaRID models, for certain seats. © 2013 Elsevier Ltd. All rights reserved.
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