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Search: WFRF:(Hepojoki J) > (2020-2023)

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  • Rissanen, Ilona, et al. (author)
  • Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein
  • 2020
  • In: eLIFE. - : eLife Sciences Publications, Ltd. - 2050-084X. ; 9
  • Journal article (peer-reviewed)abstract
    • The intricate lattice of Gn and Gc glycoprotein spike complexes on the hantavirus envelope facilitates host-cell entry and is the primary target of the neutralizing antibody-mediated immune response. Through study of a neutralizing monoclonal antibody termed mAb P-4G2, which neutralizes the zoonotic pathogen Puumala virus (PUUV), we provide a molecular-level basis for antibody-mediated targeting of the hantaviral glycoprotein lattice. Crystallographic analysis demonstrates that P-4G2 binds to a multi-domain site on PUUV Gc and may preclude fusogenic rearrangements of the glycoprotein that are required for host-cell entry. Furthermore, cryoelectron microscopy of PUUV-like particles in the presence of P-4G2 reveals a lattice-independent configuration of the Gc, demonstrating that P-4G2 perturbs the (Gn-Gc)(4) lattice. This work provides a structure-based blueprint for rationalizing antibody-mediated targeting of hantaviruses.
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  • Result 1-9 of 9

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