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- Szatmari, Peter, et al.
(author)
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Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
- 2007
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 39:3, s. 319-328
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Journal article (peer-reviewed)abstract
- Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,168 families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs.
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- Herbert, Roger, 1966-, et al.
(author)
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Using ash in a sustainable society, Swedish R&D programme 2002 - 2008
- 2009
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In: <em>Proceedings Sardinia 2009, Twelfth International Waste Management and Landfill Symposium</em>.
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Conference paper (peer-reviewed)abstract
- In Sweden, producers of combustion residues have since 2002 implemented acollaborative applied R&D programme aimed at the utilisation of combustion residues (ash). Thefuels are biomass, wastes, peat – any fuel but coal. In this contribution the main lines of theprogramme are described: ash a geotechnical material e.g. in roads, landfill construction andclosure and recycling nutrients in wood ash. Technical as well as environmental questions havebeen addressed, with a slight emphasis on environment as non-technical issues are important.Selected results from some of the ca 100 projects carried out since the inception of the AshProgramme are presented.
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- Kostova, Nora, et al.
(author)
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Immunohistochemical demonstration of histone H10 in human breast carcinoma
- 2005
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In: Histochemistry and Cell Biology. - : Springer Science and Business Media LLC. - 0948-6143 .- 1432-119X. ; 124:5, s. 435-443
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Journal article (peer-reviewed)abstract
- Histone H10 is a linker histone subvariant present in tissues of low proliferation rate. It is supposed to participate in the expression and maintenance of the terminal differentiation phenotype. The aim of this work was to study histone H10 distribution in human breast carcinoma and its relationship with the processes of proliferation and differentiation. Most of the cells in carcinomas of moderate and high level of differentiation expressed histone H10 including cells invading connective and adipose tissues. In low differentiated tumours, the number of H10 expressing cells was considerably lower. Staining of myoepithelial cells, when seen, and of stromal fibroblasts was variable. The metastatic malignant cells in the lymph nodes also accumulated H10 but lymphocytes were always negative. All immunopositive malignant cells exhibited signs of polymorphism. Double H1 0/Ki-67 staining showed that the growth fraction in more differentiated tumours belonged to the H10-positive cells, while in poorly differentiated carcinomas it also included a cell subpopulation not expressing H10. If expressed, p27Kip1 was always found in H10-positive cells. These findings are inconsistent with the widespread view that histone H10 is expressed only in terminally differentiated cells. Rather, they suggest that the protein is expressed in cells in a prolonged intermitotic period irrespective of their level of differentiation. Double H10/Ki-67 immunostaining could be a useful tool in studying the growth fraction in tumours. © Springer-Verlag 2005.
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