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1.	Laurent, SA, et al. (author) γ-Secretase directly sheds the survival receptor BCMA from plasma cells 2015 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6, s. 7333- Journal article (peer-reviewed)abstract Survival of plasma cells is regulated by B-cell maturation antigen (BCMA), a membrane-bound receptor activated by its agonist ligands BAFF and APRIL. Here we report that γ-secretase directly cleaves BCMA, without prior truncation by another protease. This direct shedding is facilitated by the short length of BCMA’s extracellular domain. In vitro, γ-secretase reduces BCMA-mediated NF-κB activation. In addition, γ-secretase releases soluble BCMA (sBCMA) that acts as a decoy neutralizing APRIL. In vivo, inhibition of γ-secretase enhances BCMA surface expression in plasma cells and increases their number in the bone marrow. Furthermore, in multiple sclerosis, sBCMA levels in spinal fluid are elevated and associated with intracerebral IgG production; in systemic lupus erythematosus, sBCMA levels in serum are elevated and correlate with disease activity. Together, shedding of BCMA by γ-secretase controls plasma cells in the bone marrow and yields a potential biomarker for B-cell involvement in human autoimmune diseases.
2.	Alexander, T, et al. (author) SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking 2015 In: Bone marrow transplantation. - : Springer Science and Business Media LLC. - 1476-5365 .- 0268-3369. ; 50:2, s. 173-180 Journal article (peer-reviewed)

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Alexander, T (2); Hiepe, F (2); Olsson, T (1); Khademi, M. (1); Martin, T. (1); Snowden, JA (1); show more...; Greco, R (1); LeBlanc, K (1); Weber, F (1); Saccardi, R (1); Farge, D (1); Bondanza, A (1); Muraro, PA (1); Daikeler, T (1); Kazmi, M (1); Hawkey, C (1); Simoes, P (1); Fibbe, WE (1); Moore, J (1); Snarski, E (1); Velardi, A (1); Toubert, A (1); Cheng, QY (1); Krumbholz, M. (1); Meinl, E (1); Hohlfeld, R (1); Schmidt-Supprian, M (1); Hauck, SM (1); Rubsamen, H (1); Lichtenthaler, SF (1); Wekerle, H (1); Jenne, D. (1); Hoffmann, FS (1); Laurent, SA (1); Kuhn, PH (1); Chu, YY (1); Schuh, E (1); Wanngren, J (1); Pfister, HW (1); show less...

University: Karolinska Institutet (2)

Language: English (2)

Year: 2015 (2)Undo refine

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