| 1. |
- Bächli, Heidi, et al.
(author)
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Skull base and maxillofacial fractures : two centre study with correlation of clinical findings with a comprehensive craniofacial classification system
- 2009
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In: Journal of Cranio-Maxillofacial Surgery. - : Elsevier BV. - 1010-5182 .- 1878-4119. ; 37:6, s. 305-11
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Journal article (peer-reviewed)abstract
- PURPOSE: A comprehensive classification based on high resolution computed tomography (CT) of the whole craniofacial region was correlated with clinical findings of combined skull base and maxillofacial fractures. MATERIAL AND METHODS: In a study of two clinical centres, 70 patients with such injuries were admitted at the Universities of Basel (n=29) and Uppsala (n=41). Clinical signs (rhinorrhoea, periorbital haematoma and pneumencephalus) and surgical versus conservative treatment were correlated with a cranio-maxillofacial injury severity score (CMF-ISS) calculated from the classification system. Fracture classifications were decided in consensus on the basis of CT and semiautomatic classification software. The classification system defined 3 fracture types (A, B, C), 3 groups (A1, A2, A3), and 3 subgroups (A1.1, A1.2, A1.3) with increasing severity from A1.1 (lowest) to C3.3 (highest). RESULTS: Of 70 patients, 43 were operated upon and 27 conservatively treated. The operated patients had significantly higher severity scores than non-operated. Patients with or without periorbital haematoma do not differ significantly in the severity score. The severity of the CMF-ISS score was significantly associated (two sample T-test P<0.01) with the occurrence of pneumencephalus, rhinorrhoea and treatment approach. CONCLUSION: Based on our present results, this system seems to be clinical useful for operative decisions and interventions.
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| 2. |
- Cesaro, Simone, et al.
(author)
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Cidofovir for BK Virus-Associated Hemorrhagic Cystitis: A Retrospective Study
- 2009
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In: Clinical Infectious Diseases. - : Oxford University Press (OUP). - 1537-6591 .- 1058-4838. ; 49:2, s. 233-240
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Journal article (peer-reviewed)abstract
- Background. BK virus-associated hemorrhagic cystitis (BKV-HC) is a severe complication after allogeneic hematopoietic stem cell transplantation (HSCT), but antiviral treatment for this condition has not been evaluated. Methods. We conducted a retrospective survey on the safety and outcome of cidofovir treatment for patients with BKV-HC in centers affiliated with the European Group for Blood and Marrow Transplantation. Results. From 1 April 2004 to 31 December 2007, 62 patients received a diagnosis of BKV-HC after a median interval of 35 days after HSCT (range, 3-577 days). Fifty-seven patients (92%) received intravenous cidofovir, whereas 5 patients received cidofovir intravesically. Complete response (CR) was recorded in 38 (67%) of 57 patients with HC treated with intravenous cidofovir, whereas partial response (PR) was documented in 7 patients (12%). CR was documented in 3 patients and PR in 1 patient with HC treated with intravesical cidofovir. A reduction of 1-3 logs in BKV load was documented in 8 of the 10 patients achieving CR. Mild-to-moderate toxic effects were recorded in 18 of 57 patients who received intravenous cidofovir administration. In a multivariate analysis, the factors significantly associated with response to cidofovir were the stem cell source (Pp. 01) and the use of total body irradiation (P = .03). After a median follow-up of 287 days, overall survival and total treatment-related mortality rates were 63% and 40% for patients achieving CR, compared with 14% and 72% for patients with PR or no response to cidofovir, respectively (P < .001 and P = .001, respectively). Conclusions. Cidofovir may be a potentially effective therapy for BKV-HC, but evidence supporting its use requires randomized controlled trials.
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| 3. |
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| 4. |
- Hahn, Gabriele, et al.
(author)
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Pharmacokinetics and safety of gadobutrol-enhanced magnetic resonance imaging in pediatric patients
- 2009
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In: Investigative Radiology. - 0020-9996 .- 1536-0210. ; 44:12, s. 776-783
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Journal article (peer-reviewed)abstract
- OBJECTIVES: This clinical study investigated the pharmacokinetics and safety of gadobutrol, a magnetic resonance (MR) imaging extracellular contrast agent, in pediatric patients aged 2 to 17 years. MATERIALS AND METHODS: In this open-label, multicenter study, patients scheduled for routine contrast-enhanced MR imaging of the brain, spine, liver or kidney, or MR angiography received a single intravenous injection of gadobutrol (0.1 mmol/kg/0.1 mL/kg). Patients were stratified by age groups (2-6, 7-11, and 12-17 years). Blood and urine samples were collected at prespecified time points and analyzed for gadolinium concentrations. Plasma data were evaluated by means of a nonlinear mixed effects model, and urine data were analyzed using descriptive statistics. In addition, the safety of gadobutrol was evaluated. RESULTS: A total of 130 patients (2-6 years, n = 45; 7-11 years, n = 39; 12-17 years, n = 46) were included in the final population pharmacokinetic analysis. Gadobutrol pharmacokinetics in children aged 2 to 17 years were adequately described by an open 2-compartment model with elimination from the central compartment. The median estimates (2.5th percentile, 97.5th percentile) of body weight-normalized total body clearance (L/h/kg) per age group were 0.10 (0.05, 0.17) for all ages, 0.13 (0.09, 0.17) in the 2 to 6 year age group, 0.10 (0.05, 0.17) in the 7 to 11 year age group and 0.09 (0.05, 0.10) in the 12 to 17 year age group. The body weight-normalized median estimates of total volume of distribution (L/kg) were 0.20 (0.12, 0.28) for all ages, 0.24 (0.20, 0.28) in the 2 to 6 year age group, 0.19 (0.14, 0.23) in the 7 to 11 year age group and 0.18 (0.092, 0.23) in the 12 to 17 year age group. Median gadolinium plasma concentrations at 20 minutes postinjection were simulated using the population pharmacokinetic model and ranged from 414 (13 kg subject) to 518 micromol/L (65 kg subject). Body weight was identified as the major covariate influencing the pharmacokinetic parameters of total body clearance and central volume of distribution. Age was not found to be an additional independent parameter. The median amount of renally excreted gadolinium was 77.0% of the administered dose within 6 hours postinjection, indicating that gadobutrol was renally excreted in this pediatric population aged 2 to 17 years. Gadobutrol was well tolerated, with drug-related adverse events of mild intensity reported for 8 (5.8%) of 138 patients. CONCLUSIONS: Observed differences in pharmacokinetics were attributed to body weight, with no additional independent effect of age. Thus, no dose adjustment from the standard dose of gadobutrol in adults based on body weight (0.1 mmol/kg) is necessary in pediatric patients aged 2 to 17 years. Gadobutrol was safe and well tolerated in the pediatric population in this study.
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| 5. |
- Hirsch, Martin R., et al.
(author)
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Design and implementation of heterogeneous distributed controllers according to the IEC 61499 standard : A case study
- 2007
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In: 2006 4th IEEE International Conference on Industrial Informatics. - Piscataway, NJ : IEEE Communications Society. - 0780397002 ; , s. 829-834
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Conference paper (peer-reviewed)abstract
- This paper addresses solutions on integration and reuse of heterogeneous distributed controllers. In particular it shows the way to integrate the emerging IEC 61499 standard into the established IEC 61131 automation frameworks. It is illustrated on example of a modular manufacturing cell with distributed control units, how to realize distribution of heterogeneous controllers using the IEC 61499 standard and how to integrate these controllers into the plant formerly controlled by distributed PLCs. Therefore, methodologies and patterns for the design of distributed controllers and their implementation variants are introduced. In addition, the paper describes the details of a higher level communication protocol used to implement interaction between the modules. A framework for the simulation of IEC 61499 applications is also introduced
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| 6. |
- Hirsch, Martin R., et al.
(author)
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IEC 61499 function blocks for distributed networked embedded applications
- 2007
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In: 2006 4th IEEE International Conference on Industrial Informatics. - Piscataway, NJ : IEEE Communications Society. ; , s. 670-675
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Conference paper (peer-reviewed)abstract
- This paper presents a case study on the use of the IEC61499 reference component architecture in automotive electronics that is a traditional domain of embedded systems application. The proposed design approach allows for combination of distributed embedded control with off-line and on line simulation. The benefits of the approach are: the higher level of design leading to the increased level of component re-use, the flexibility and hardware independence, increased reliability on account of the use of predictive control and formal verification
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| 7. |
- Rodriguez, Henry, et al.
(author)
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Recommendations from the 2008 International Summit on Proteomics Data Release and Sharing Policy : The Amsterdam Principles
- 2009
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In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 8:7, s. 3689-3692
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Journal article (peer-reviewed)abstract
- Policies supporting the rapid and open sharing of genomic data have directly fueled the accelerated pace of discovery in large-scale genomics research. The proteomics community is starting to implement analogous policies and infrastructure for making large-scale proteomics data widely available on a precompetitive basis. On August 14, 2008, the National Cancer Institute (NCI) convened the "International Summit on Proteomics Data Release and Sharing Policy" in Amsterdam, The Netherlands, to identify and address potential roadblocks to rapid and open access to data. The six principles agreed upon by key stakeholders at the summit addressed issues surrounding (1) timing, (2) comprehensiveness, (3) format, (4) deposition to repositories, (5) quality metrics, and (6) responsibility for proteomics data release. This summit report explores various approaches to develop a framework of data release and sharing principles that will most effectively fulfill the needs of the funding agencies and the research community.
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| 8. |
- Vyatkin, Valeriy, et al.
(author)
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Systematic design and implementation of distributed controllers in industrial automation
- 2006
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In: 2006 IEEE Conference on Emerging Technologies & Factory Automation. - Piscataway, NJ : IEEE Communications Society. ; , s. 633-640
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Conference paper (peer-reviewed)abstract
- This paper discusses systematic approaches to the design of distributed controllers in industrial automation systems. Several design approaches are compared that lead to the distributed control of manufacturing machines and their parts. In particular, a decentralized control method is introduced that does not require a master controller. The implementation frameworks of IEC 61131-3 and IEC 61499 are checked on their fitness to the distributed control. A migration method from a PLC-based control to IEC 61499 is illustrated. A layered architecture for distributed controllers is introduced and tested on examples.
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| 9. |
- Zazzi, Åsa, et al.
(author)
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Structural investigations of natural and synthetic chlorite minerals by X-ray diffraction, Mossbauer spectroscopy and solid-state nuclear magnetic resonance
- 2006
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In: Clays and clay minerals. - 0009-8604 .- 1552-8367. ; 54:2, s. 252-265
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Journal article (peer-reviewed)abstract
- The structures of one synthetic and two natural chlorites of the chlinochlore type were explored using X-ray diffraction, magic-angle spinning nuclear magnetic resonance (NMR) and Mossbauer spectroscopy. Rietveld refinements indicated that all structures are of the trioctahedral ordered IIb polytype. Mossbauer spectra provided the ratio Fe-II/Fe-III but gave no evidence for the presence of Fe-III in the brucite-like sheet. We also report unit-cell parameters, Mossbauer isomeric shifts, Si-29 NMR chemical shifts as well as Al-27 isotropic shifts and quadrupolar coupling parameters. Very broad Si-29 NMR peaks from the natural samples prevented us from obtaining accurate information on the Si-Al ordering in the tetrahedral sheets; the limitations of Si-29 NMR as applied to natural chlorites are discussed. High-resolution 3QMAS NMR resolved the Al-27 signal of the M4 octahedral site in the brucite-like sheet from the other three Al signals of crystallographically inequivalent octahedral positions.
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