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- MacGregor, Stuart, et al.
(author)
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Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
- 2011
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:11, s. 1114-1118
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Journal article (peer-reviewed)abstract
- We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several previously characterized melanoma-associated loci at MC1R, ASIP and MTAP-CDKN2A. We selected variants at nine loci for replication in three independent case-control studies (Europe: 2,804 subjects with melanoma, 7,618 control subjects; United States 1: 1,804 subjects with melanoma, 1,026 control subjects; United States 2: 585 subjects with melanoma, 6,500 control subjects). The combined meta-analysis of all case-control studies identified a new susceptibility locus at 1q21.3 (rs7412746, P = 9.0 x 10(-11), OR in combined replication cohorts of 0.89 (95% CI 0.85-0.95)). We also show evidence suggesting that melanoma associates with 1q42.12 (rs3219090, P = 9.3 x 10(-8)). The associated variants at the 1q21.3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1. Variants at the 1q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density.
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- Holland, Jennifer A., et al.
(author)
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Stepfamily childbearing in Sweden : Quantum and tempo effects, 1950-99
- 2011
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In: Population Studies. - : Informa UK Limited. - 0032-4728 .- 1477-4747. ; 65:1, s. 115-128
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Journal article (peer-reviewed)abstract
- Several studies have demonstrated that stepfamily couples have a higher risk of childbearing than couples in a stable union with the same total number of children. Analysing retrospective data from a nationally representative sample of Swedish adults, we find that the risk of a second or third birth is higher when it is the first or second child in a new union. We also find a faster pace of childbearing after stepfamily formation than after a shared birth. The risk of a second birth (in total) is only a little higher in the first two years after stepfamily formation than in the first two years after a shared birth, and thereafter the risk is lower for stepfamilies. The risk of a third birth (in total) is particularly high early in the stepfamily union and remains higher than that of couples with two shared children for at least five years. The stepfamily difference was lower after than before 1980, when the Swedish government introduced parental leave incentives for short birth intervals.
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