| 1. |
- Odeberg Glasenapp, Astrid, et al.
(author)
-
Next level of corrugated board research
- 2019
-
In: 29th IAPRI Symposium on packaging, 2019.
-
Conference paper (other academic/artistic)abstract
- For the first time in the Bioeconomy research program at RISE, corrugatedboard has an own research area. Research is building around the main driving forcesin the corrugated board value chain like e-commerce, improved box performance anddigital printing. The main weakness of corrugated board, its moisture sensitivity, isalso addressed.These main driving forces and weaknesses of corrugated board are mirrored in thethemes of this large research program area:Fibre sorption and deformation mechanismsFundamental knowledge on the mechanisms behind moisture sorption and deformation on fibre level is developed to increase moisture and creep resistance throughmodification of paper materials. State of the art methods for characterization ofthe fibre ultra- and nano-structure such as Fourier transform infra-red spectroscopy(FTIR), small angle X-ray scattering (SAXS), and wide angle X-ray scattering (WAXS)give new insights on mechanisms and clarify effects of moisture as well as chemicalmodifications.Papermaking for improved base sheetsConcepts that are explored are fibre-based strength additives produced with novelrefining techniques, and modified ZD-profiles in the sheet for better mechanical properties.Box mechanicsMechanical performance of structures such as corrugated board boxes can be predicted through physically based mathematical modelling by taking the behaviour ofthe constituent materials as well as the geometry into account. Appropriate materialmodels for the corrugated board are identified and finite element models for simulation of corrugated board packaging performance are developed.Tool for inkjet printability on corrugatedThere is a genuine need for improved inkjet printability on corrugated materials thanksto rapid development in e-commerce as well as digitalization along the corrugatedvalue chain. Effective measurement methods and knowledge around ink-substrateinteractions are developed to enable board producers and converters to have effective product development and predictable printability on not only liners but also oncorrugated materials.
|
|
| 2. |
- Seifert, Mariam B., et al.
(author)
-
Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early-onset lone atrial fibrillation
- 2019
-
In: Annals of Noninvasive Electrocardiology. - : Wiley. - 1082-720X .- 1542-474X. ; 24:6
-
Journal article (peer-reviewed)abstract
- Background: Abnormal P-wave morphology (PWM) has been associated with a history of atrial fibrillation (AF) in earlier studies. Although lone AF is believed to have substantial genetic basis, studies on associations between single nucleotide polymorphisms (SNP) linked to lone AF and PWM have not been reported. We aimed to assess whether SNPs previously associated with lone AF (rs2200733, rs13376333, rs3807989, and rs11047543) are also linked to P-wave abnormalities. Methods: Four SNPs were studied in 176 unrelated individuals with early-onset lone AF (age at onset <50 years), median age 38 years (19–63 years), 149 men. Using sinus rhythm ECG, orthogonal PWM was classified as Type 1—positive in leads X and Y and negative in lead Z, Type 2—positive in leads X and Y and biphasic (−/+) in lead Z, Type 3—positive in lead X and biphasic in lead Y (+/−), and the remaining as atypical. Results: Two SNPs were found to be significantly associated with altered P-wave morphology distribution: rs3807989 near the gene CAV1/CAV2 and rs11047543 near the gene SOX5. Both SNPs were associated with a higher risk of non-Type 1 P-wave morphology (rs3807989: OR = 4.8, 95% CI = 2.3–10.2, p < 0.001; rs11047543: OR = 4.7, 95% CI = 1.1–20.5, p = 0.04). No association was observed for rs2200733 and rs13376333. Conclusion: In this study, the two variants rs3807989 and rs11047543, previously associated with PR interval and lone AF, were associated with altered P-wave morphology distribution in patients with early-onset lone AF. These findings suggest that common genetic variants may modify atrial conduction properties.
|
|
