| 1. |
- Hasbak, Philip, et al.
(author)
-
The vasorelaxant effect of adrenomedullin, proadrenomedullin N-terminal 20 peptide and amylin in human skin
- 2006
-
In: Basic & Clinical Pharmacology & Toxicology. - : Wiley. - 1742-7843. ; 99:2, s. 162-167
-
Journal article (peer-reviewed)abstract
- In this study we aimed to assess in vivo, the vasodilator effects of adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP) and amylin in human skin vasculature and compare the responses to the effects mediated by the endogenenous neuropeptides calcitonin gene-related peptide (CGRP) and substance P and to examine the mRNA expression of calcitonin receptor-like receptor (CL-R) and receptor-activity modifying proteins, RAMP1, RAMP 2 and RAMP3 in human subcutaneous arteries. Changes in skin blood flow of the forearm were measured using a Laser Doppler Imager after intradermal injection of the peptides. The mRNA expression was assessed by real-time reverse transcriptase polymerase chain reaction (real-time PCR). CGRP, adrenomedullin and amylin induced concentration-dependent, long-lasting increases in skin blood flow. The response to PAMP was shorter in duration appearing similar to the transient response induced by substance P. PAMP (10(-6)-10(-5)M) caused distinct itch sensation and local erythema. This effect could be abolished when combining the histamine H-1-receptor antagonist mepyramin and PAMP. Real-time PCR data showed a higher level of mRNA for RAMP2 than CL-R, RAMP1 and RAMP3 in the tissue. Though the PCR data demonstrated the presence of mRNA for both CGRP1 and adrenomedullin receptors the rank order of potency (CGRP > adrenomedullin > amylin) for the blood flow increase indicated vasodilatation for these peptides was induced by activation of CGRP1 receptors. Intradermal injection of CGRP, adrenomedullin and amylin induces long lasting dilatation of human skin vasculature by activation of CGRP1 receptors. PAMP induces transient vasodilatation. PAMP but not CGRP, adrenomedullin and amylin causes itch sensation and local erythema. The transient effect on vasodilatation as response to PAMP is discussed.
|
|
| 2. |
- Skovgaard-Petersen, Karen, et al.
(author)
-
Fra støv til guld : Brugsbøger og skillingstryk fra Det Kongelige Bibliotek
- 2006
-
Book (other academic/artistic)abstract
- Katalogbog udgivet i forbindelse med den første udstilling i Det Kongelige Biblioteks nye udstillingssal, Montanasalen. Emnet for udstillingen er ældre tiders danske brugsbøger, skillingstryk, romaner m.m. Udstillingen tager udgangspunkt i et citat af en engelsk biblioteksmand: ’The dust of one age is the gold of another, som ofte anvendes, når talen falder på bevaring af kulturarven verden over. Citatet udtrykker, at det, der i samtiden kan forekomme værdiløst og ligegyldigt – f.eks. en reklamebrochure – kan få stor betydning som kulturhistorisk kilde for senere generationer.Katalogbogen, der bærer samme navn som udstillingen, indeholder, foruden en indledning til emnet om ”De oversete bøger” af Karen Skovgaard-Petersen, 4 artikler som forholder sig til nogle af udstillingens emner: - Charlotte Appel: Når det almindelige bliver sjældent – om abc’en og andre skolebøger - Henrik Horstbøll: Kunsten at dø – ars moriendi - Jens Henrik Koudal: Musikere, amatører og en ny type dansksprogede lærebøger - Michael Harbsmeier: Et grønlandsk spejl. Katalogbogen kan læses uafhængigt af udstillingen og kan således ses som et supplement til et besøg i den nye sal. Katalogbogen har dansk/engelsk paralleltekst.
|
|
