| 1. |
- Hu, Qitao, et al.
(författare)
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Improving Selectivity of Ion-Sensitive Membrane by Polyethylene Glycol Doping
- 2021
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Ingår i: Sensors and actuators. B, Chemical. - : Elsevier. - 0925-4005 .- 1873-3077. ; 328
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Tidskriftsartikel (refereegranskat)abstract
- Hydrophobic ions can generate considerable interference to ion detection in a complex analyte with membrane-based ion-selective sensors, due to the hydrophobic interaction. In this paper, we demonstrate that the interference from the hydrophobic interaction to the sensors can be significantly reduced by incorporating hydrophilic polyethylene glycol (PEG) into the membrane. The sensor is a silicon nanowire field-effect transistor (SiNWFET) with its surface functionalized with an ionophore-doped mixed-matrix membrane (MMM), where the ionophore is either a commercial Na-ionophore Ⅲ or a novel synthetic metal-organic supercontainer. The incorporation of PEG suppresses the partitioning of hydrophobic ions into the MMM and thus reduces their interference to the detection of target ions. This is evidenced with an improvement in selectivity for Na+ detection in the presence of interfering methylene blue (MB+) ion by more than an order of magnitude. It further enables detection of Na+ and MB+ using a SiNWFET sensor array in a multiplexed manner with controlled susceptivity to cross-interference and a greatly expanded dynamic range.
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| 2. |
- Hu, Qitao, et al.
(författare)
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Ion sensing with single charge resolution using sub-10-nm electrical double layer-gated silicon nanowire transistors
- 2021
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 7:49
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Tidskriftsartikel (refereegranskat)abstract
- Electrical sensors have been widely explored for the analysis of chemical/biological species. Ion detection with single charge resolution is the ultimate sensitivity goal of such sensors, which is yet to be experimentally demonstrated. Here, the events of capturing and emitting a single hydrogen ion (H+) at the solid/liquid interface are directly detected using sub-10-nm electrical double layer-gated silicon nanowire field-effect transistors (SiNWFETs). The SiNWFETs are fabricated using a complementary metal-oxide-semiconductor compatible process, with a surface reassembling step to minimize the device noise. An individually activated surface Si dangling bond (DB) acts as the single H+ receptor. Discrete current signals, generated by the single H+-DB interactions via local Coulomb scattering, are directly detected by the SiNWFETs. The single H+-DB interaction kinetics is systematically investigated. Our SiNWFETs demonstrate unprecedented capability for electrical sensing applications, especially for investigating the physics of solid/liquid interfacial interactions at the single charge level.
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| 3. |
- Hu, Qitao
(författare)
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Silicon Nanowire Based Electronic Devices for Sensing Applications
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Silicon nanowire (SiNW) based electronic devices fabricated with a complementary metal-oxide-semiconductor (CMOS) compatible process have wide-range and promising applications in sensing area. These SiNW sensors own high sensitivity, low-cost mass production possibility, and high integration density. In this thesis, we design and fabricate SiNW electronic devices with the CMOS-compatible process on silicon-on-insulator (SOI) substrates and explore their applications for ion sensing and quantum sensing. The thesis starts with ion sensing using SiNW field-effect transistors (SiNWFETs). The specific interaction between a sensing layer and analyte generates a change of local charge density and electrical potential, which can effectively modulate the conductance of SiNW channel. Multiplexed detection of molecular (MB+) and elemental (Na+) ions is demonstrated using a SiNWFET array, which is functionalized with ionophore-incorporated mixed-matrix membranes (MMMs). As a follow-up, polyethylene glycol (PEG) doping strategy is explored to suppress interference from the hydrophobic molecular ion and expand the multiplexed detection range. Then, the SiNW is downscaled to sub-10 nm with a gate-oxide-free configuration for single charge detection in liquid. We directly observe the capture and emission of a single H+ ion with individually activated Si dangling bonds (DBs) on the SiNW surface. This work demonstrates the unprecedented ability of the sub-10 nm SiNWFET for investigating the physics of the solid/liquid interface at single charge level.Apart from ion sensing, the SiNWFET can be suspended and act as a nanoelectromechanical resonator aiming for electrically detecting potential quantized mechanical vibration at low temperature. A suspended SiNW based single-hole transistor (SHT) is explored as a nanoelectromechanical resonator at 20 mK. Mechanical vibration is transduced to electrical readout by the SHT, and the transduction mechanism is dominated by piezoresistive effect. A giant effective piezoresistive gauge factor (~6000) with a strong correlation to the single-hole tunneling is also estimated. This hybrid device is demonstrated as a promising system to investigate macroscopic quantum behaviors of vibration phonon modes.Noise, including intrinsic device noise and environmental interference, is a serious concern for sensing applications of SiNW electronic devices. A H2 annealing process is explored to repair the SiNW surface defects and thus reduce the intrinsic noise by one order of magnitude. To suppress the external interference, lateral bipolar junction transistors (LBJTs) are fabricated on SOI substrate for local signal amplification of the SiNW sensors. Current gain and overall signal-to-noise ratio of the LBJTs are also optimized with an appropriate substrate voltage.
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| 4. |
- Xu, Xingxing, et al.
(författare)
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Redox Buffering Effects in Potentiometric Detection of DNA Using Thiol-modified Gold Electrodes
- 2021
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Ingår i: ACS Sensors. - : American Chemical Society (ACS). - 2379-3694. ; 6:7, s. 2546-2552
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Tidskriftsartikel (refereegranskat)abstract
- Label-free potentiometric detection of DNA molecules using a field-effect transistor (FET) with a gold gate offers an electrical sensing platform for rapid, straightforward, and inexpensive analyses of nucleic acid samples. To induce DNA hybridization on the FET sensor surface to enable potentiometric detection, probe DNA that is complementary to the target DNA has to be immobilized on the FET gate surface. A common method for probe DNA functionalization is based on thiol-gold chemistry, immobilizing thiol-modified probe DNA on a gold gate with thiol-gold bonds. A self-assembled monolayer (SAM), based on the same thiol-gold chemistry, is also needed to passivate the rest of the gold gate surface to prevent non-specific adsorption and to enable favorable steric configuration of the probe DNA. Herein, the applicability of such FET based potentiometric DNA sensing was carefully investigated, using a silicon nanoribbon FET (SiNRFET) with a gold sensing gate modified with thiol-gold chemistry. We discover that the potential of the gold sensing electrode was determined by the mixed potential of the gold-thiol and gold-oxygen redox interactions. This mixed potential gives rise to a redox buffer effect which buffers the change in the surface charge induced by the DNA hybridization, thus suppressing the potentiometric signal. Analogous redox buffer effects may also be present for other types of potentiometric detections of biomarkers based on thiol-gold chemistry.
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| 5. |
- Yu, Yingtao, et al.
(författare)
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Ultra-Low Noise Schottky Junction Tri-Gate Silicon Nanowire FET on Bonded Silicon-on Insulator Substrate
- 2021
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Ingår i: IEEE Electron Device Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 0741-3106 .- 1558-0563. ; 42:4, s. 469-472
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Tidskriftsartikel (refereegranskat)abstract
- Random trapping and detrapping of charged carriers in the vicinity of gate oxide/Si interface has for long been considered as the dominant noise source in Si nanowire (SiNW) FET-based biochemical sensors. Here we extend our previous work presenting a Schottky junction tri-gate SiNWFETs (SJGFET) fabricated on a bonded silicon-on-insulator (SOI) substrate, aiming for ultra-low device noise generation. The SJGFET exhibits near-ideal gate coupling efficiency with a subthreshold swing of ~66 mV/dec. Its gate-referred voltage noise, S vg , are 1.2×10 -10 and 1.1×10 -11 V 2 μm 2 /Hz at 1 and 10 Hz, respectively. These S vg values are significantly lower than that of previously reported FET-based sensors. More importantly, S vg of the SJGFET are below the reported voltage noise generated by the oxide/electrolyte sensing interface. Using our SJGFET as the signal transducer can greatly relieve the concern of the adverse effect from the intrinsic device noise in biochemical sensing applications.
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