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| 2. |
- Hummel, Thomas, et al.
(author)
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Androstadienone odor thresholds in adolescents.
- 2005
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In: Horm Behav. - 0018-506X. ; 47:3, s. 306-10
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Journal article (peer-reviewed)abstract
- A sex-related difference in olfactory sensitivity to androstenone has been reported to occur during adolescence. More males than females exhibited anosmia to androstenone, or an increase in androstenone threshold with age. The current study addressed the question whether similar, sexually dimorphic effects of aging over puberty can also be found for androstadienone. A total of 102 subjects participated (36 females, 66 males). Similar to previous investigations, subjects were divided into a group of 47 individuals with a mean age of 13.3 years, defined as pre/peri-pubertal, and a group of 55 subjects with a mean age of 17.1 years, defined as post-pubertal. All subjects underwent tests for verbal abilities, general olfactory function, and measurements of androstadienone thresholds. The study provided the following major results: (1) Male subjects exhibited higher androstadienone sensitivity in the pre/peri-pubertal group as compared to the post-pubertal group. This difference was not observed in female subjects. Correspondingly, a negative correlation between age and androstadienone sensitivity was found for male subjects, but not for female subjects. (2) In contrast to this sex-specific change of the androstadienone odor threshold, verbal skills and odor identification abilities increased with age in all subjects regardless of their sex. In conclusion, the present observations confirm previous research on sex-differentiated effects of aging during puberty on sensitivity towards odorous steroids. While the underlying causes are unknown, it may be hypothesized that the decreased sensitivity could result from the increased endogenous levels of androstadienone in male subjects. Future studies should include both steroid and non-steroid odorants to futher explore these age-related changes.
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| 3. |
- Konstantinidis, Iordanis, et al.
(author)
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Identification of unpleasant odors is independent of age.
- 2006
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In: Archives of Clinical Neuropsychology. - : Oxford University Press (OUP). - 0887-6177. ; 21:7, s. 615-621
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Journal article (peer-reviewed)abstract
- The purpose of this study was to investigate (a) the relationship between identification proficiency for specific odors and chronological age and (b) to determine whether the relationships were related to perceived quality (i.e., judgments of familiarity, intensity, and hedonics) of the odor item. Data from 472 subjects (227 men, 245 women) ranging in age from 18-79 years were assessed in a cued identification test comprising 16 odors. The results indicated a reliable age effect in overall odor identification performance. Further analyses indicated that the observed age-related deficit was odorant-specific, with some odors being equally well identified across age cohorts and others showing sensitivity to the process of aging. Additional examination regarding the observed age-differential effects across the different odor types indicated that these may be understood according to the pleasantness/upleasantness associated with the odor. Specifically, odors perceived as unpleasant showed age invariance whereas odors rated as pleasant exhibited age sensitivity.
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| 4. |
- Landis, Basile Nicolas, et al.
(author)
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"Taste Strips" - a rapid, lateralized, gustatory bedside identification test based on impregnated filter papers.
- 2009
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In: Journal of neurology. - : Springer Science and Business Media LLC. - 1432-1459 .- 0340-5354. ; 256:2, s. 242-8
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To elaborate normative values for a clinical psychophysical taste test ("Taste Strips"). BACKGROUND: The "Taste Strips" are a psychophysical chemical taste test. So far, no definitive normative data had been published and only a fairly small sample size has been investigated. In light of this shortcoming for this easy, reliable and quick taste testing device, we attempted to provide normative values suitable for the clinical use. SETTING: Normative value acquisition study, multicenter study. METHODS: The investigation involved 537 participants reporting a normal sense of smell and taste (318 female, 219 male, mean age 44 years, age range 18-87 years). The taste test was based on spoon-shaped filter paper strips ("Taste Strips") impregnated with the four (sweet, sour, salty, and bitter) taste qualities in four different concentrations. The strips were placed on the left or right side of the anterior third of the extended tongue, resulting in a total of 32 trials. With their tongue still extended, patients had to identify the taste from a list of four descriptors, i. e., sweet, sour, salty, and bitter (multiple forced-choice). To obtain an impression of overall gustatory function, the number of correctly identified tastes was summed up for a "taste score". RESULTS: Taste function decreased significantly with age. Women exhibited significantly higher taste scores than men which was true for all age groups. The taste score at the 10(th) percentile was selected as a cut-off value to distinguish normogeusia from hypogeusia. Results from a small series of patients with ageusia confirmed the clinical usefulness of the proposed normative values. CONCLUSION: The present data provide normative values for the "Taste Strips" based on over 500 subjects tested.
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| 6. |
- Lundström, Johan N., et al.
(author)
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Olfactory event-related potentials reflect individual differences in odor valence perception
- 2006
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In: Chemical Senses. - : Oxford University Press (OUP). - 0379-864X .- 1464-3553. ; 31:8, s. 705-711
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Journal article (peer-reviewed)abstract
- Investigating the neural substrates of perceived quality in olfaction using different odorants is intrinsically difficult. By utilizing individual differences in perceived quality of the odor of androstenone, we obtained a continuum of individual differences in rated valence of the same stimulus allowing investigations of its manifestation in the olfactory event-related potentials (ERPs). In an initial group consisting of 43 individuals that were screened for their verbal descriptors and sensitivity for the odor of androstenone, 22 normosmic volunteers were chosen forming 2 distinct groups with regard to verbal labels ("body odor" and "nonbody odor") for androstenone while maintaining chemical structure, concentration, and intensity constant. In the main experiment, these participants rated both intensity and pleasantness of androstenone during the recording of olfactory ERPs. There was a significant difference in rated valence between the groups but not in intensity. Participants in the body odor label group had larger amplitudes of the late positive ERP component than those in the nonbody odor label group. A negative correlation between valence and amplitudes of the late positive component for androstenone indicated that these differences were mediated by the difference in odor valence between the 2 groups. This was further supported by a comparison of ERP peaks in response to stimulation with androstenone and the invariably unpleasant hydrogen sulfide that had been used as a control. Altogether, the results suggest that the late positive component reflects the processing of odor valence. Future olfactory studies with the aim of assessing the dimension of pleasantness would benefit from the use of these interindividual differences in the perception of a specific odor.
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| 8. |
- Lundström, Johan, et al.
(author)
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Sex differentiated responses to intranasal trigeminal stimuli.
- 2005
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In: International Journal of Psychophysiology. - : Elsevier BV. - 0167-8760. ; 57:3, s. 181-186
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Journal article (peer-reviewed)abstract
- The aim of the study was to address sex-related hemispheric differences in trigeminal event-related potentials while controlling for the subjects' olfactory sensitivity. Event-related potentials to lateralized stimulation using the trigeminal stimulant CO-sub-2 were recorded in 28 healthy young subjects (16 women). There was no sex-related difference in olfactory sensitivity. Results indicated a sex-differentiated response to trigeminally induced pain. Women were found to have generally higher amplitudes and shorter latencies of the late positive component than men. Moreover, men and women exhibited different hemispheric activations in that women expressed shorter latencies over the left hemisphere than men. The pronounced sex-related difference of the late positive component suggests a cognitive/emotional impact on the processing of intranasal pain as indicated by others.
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| 9. |
- Nordin, Steven, et al.
(author)
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Chemosensory perception and event-related potentials in self-reported chemical hypersensitivity
- 2005
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In: Int Journal of Psychophysiology. ; 55:2, s. 243-255
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Journal article (peer-reviewed)abstract
- Anormal chemosensory perception has been identified as a possible mechanism underlying odor intolerance, but research in this domain has yet been rather limited. The main objective of the present study was to investigate total perceived intensity, unpleasantness, sensory irritation, and cortical activity assessed with chemosensory event-related potentials (ERPs) for three concentrations of pyridine ranging from predominantly olfactory to trigeminal in activation. Results from 19 individuals with self-reported chemical hypersensitivity and 19 controls with self-reported normal chemical sensitivity show that the hypersensitive group, compared to controls, rated the pyridine stimuli to be more intense and unpleasant, and that these group differences increased with pyridine concentration. Sensory irritation was also the perceptual dimension found to correlate strongest with score on the chemical sensitivity scale. However, no group differences were found in ERP amplitudes or latencies. These findings suggest that self-reported chemical hypersensitivity (1) can be associated with anormal chemosensory perception, (2) may be more closely related to trigeminal function than to olfaction, and (3) has a neural basis at a higher cortical level than that captured by chemosensory ERPs.
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