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| 4. |
- Cantor-Graae, E, et al.
(author)
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Aspects of stability of regional cerebral blood flow in chronic schizophrenia : an 18-year followup study.
- 1991
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In: Psychiatry Research. - 0165-1781 .- 1872-7123. ; 40:4, s. 253-66
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Journal article (peer-reviewed)abstract
- Regional cerebral blood flow (rCBF) measurements and psychiatric ratings were performed on seven schizophrenic patients (mean age = 41.4 years) who had been examined 18 years previously in a study that used similar psychiatric ratings and a comparable rCBF technique. Neither the clinical symptomatology nor the rCBF level and distribution had changed appreciably between 1972 and 1990. The findings indicate that cerebral functional activity in chronic schizophrenia remains constant in spite of continuous neuroleptic medication.
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| 5. |
- Gustafson, Ingvar, et al.
(author)
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Effects of ischemia on regional ligand binding to adrenoceptors in the rat brain
- 1992
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In: Journal of the Neurological Sciences. - 0022-510X. ; 113:2, s. 165-176
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Journal article (peer-reviewed)abstract
- Changes in ligand binding to adrenoceptors ([3H]prazosin to α1-receptors, [3H]idazoxan to α2-receptors and [125I]cyanopindolol to β-receptors) following transient cerebral ischemia were investigated using autoradiographic methods. The binding was quantified in brain sections from control rats, rats subjected to 15 min of 2-vessel occlusion ischemia, and rats with recirculation times of 1 h, 1 week or 4 weeks after ischemia. No significant change in α1-receptor binding was observed during and immediately following ischemia, but a decrease was noted in the vulnerable hippocampal CA1 region following 1 week's survival. In the parietal cortex, the ligand binding to α1-receptors increased at 4 weeks. A reduced [3H]idazoxan binding was observed 1 h after ischemia in the temporal cortex and amygdala. No change in ligand binding to β-receptors was seen in the early phase postischemia, but a marked increase had occurred in the hippocampal CA1 region at 1 and 4 weeks after ischemia (+163% and +142%, respectively), presumably due to accumulation of macrophages expressing β-receptors. The early postischemic changes in receptor binding may represent downregulation of the adrenoceptors by processes activated during ischemia, while neuronal degeneration, compensatory mechanisms in surviving neurons and proliferation of non-neuronal cells may account for the subsequent changes.
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| 7. |
- Kärnefelt, Ingvar, et al.
(author)
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Evolutionary rates in the Teloschistaceae.
- 1991
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In: Tropical lichens: Their systematics, conservation, and ecology. The Systematic Association Special Volume. - 0198577206 ; 43, s. 105-121
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Book chapter (peer-reviewed)abstract
- Abstract is not available
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| 9. |
- Westerdahl, J., et al.
(author)
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At what age do sunburn episodes play a crucial role for the development of malignant melanoma
- 1994
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In: European Journal of Cancer. - : Elsevier BV. - 0959-8049. ; 30:11, s. 1647-1654
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Journal article (peer-reviewed)abstract
- The age relationship between sunburns and malignant melanoma was investigated in a population-based, matched, case-control study from the South Swedish Health Care Region (the highest risk area for melanoma in Sweden). Between 1988 and 1990, a total of 400 patients with a first diagnosis of malignant melanoma and 640 healthy controls aged 15-75 years answered a comprehensive questionnaire including questions regarding ultraviolet radiation exposure. In addition, a literature review was performed. The average number of episodes of sunburn per year was significantly associated with malignant melanoma (relative risk, RR = 1.9 for ≥ three episodes per year versus never). Outdoor employment during the summer was associated with a decreased risk for the development of malignant melanoma (RR = 0.8). Data from case-control studies and migration studies concerning age relationship between sunburns and melanom are inconsistent. From our own data, we did not find a higher risk of melanoma developed in individuals who had experienced severe sunburns in childhood. Instead, a significantly increased risk was associated with sunburns after age 19 years, RR = 2.2 for a history of more than five times versus never. Even if the hypothesis is biologically plausible, that episodes of sunburn early in life are associated with a higher risk of melanoma, so far epidemiological evidence is scarce. There is a need for better prospective epidemiological studies addressing this issue.
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| 10. |
- Westerdahl, J., et al.
(author)
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Southern travelling habits with special reference to tumour site in Swedish melanoma patients
- 1992
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In: Anticancer research. - 0250-7005. ; 12:5, s. 1539-1542
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Journal article (peer-reviewed)abstract
- Southern travelling habits were recorded for 127 melanoma patients from southern parts of Sweden (the 56th latitude), 55 thyroid cancer patients, 100 non-Hodgkin's patients and 794 healthy controls from the same region. Melanoma patients were found to travel significantly more often south of the 45th latitude, as compared with patients with non-Hodgkin's lymphoma or thyroid carcinoma (RR = 2.2 for a difference of + 10 trips), and with the healthy controls (RR = 1.4 for a difference of + 10 trips). Considering men and women sepatately, the difference was significant only for men. Patients with melanoma had a higher educational level than the tumour controls and the healthy controls (p<0.001 and p<0.001 respectively). There was a significant correlation between high travelling frequency and high education. An increased risk related to southern travelling was present for patients with melanoma on the extremities and head and neck, as well as for patients with truncal melanoma. These findings support the concept that acute exposure to sunburn may be a risk factor for malignant melanoma.
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