| 1. |
- Hugander, A., et al.
(author)
-
Total body hyperthermia induced by a computerized microwave technique : studies in normal rats and in rats with liver tumors.
- 1983
-
In: Anticancer research. - 0250-7005. ; 3:3, s. 161-165
-
Journal article (peer-reviewed)abstract
- A computerized system for inducing total body hyperthermia by microwave irradiation was tested in rats. The tolerance to hyperthermia at different temperatures and fractions was studied as well as its effect on the growth of transplanted adenocarcinomas in the liver. Survival results indicated that 41.5 degrees C was maximum tolerated temperature both after single and repeated one hour exposures. Besides the high mortality with a greater temperature (42 degrees C) there was a significant rise in S-aspartate-amino-transferase (S-ASAT) and S-beta-hexosaminidase (beta-nagas) indicating damage of normal cells. No significant reduction of tumor volume could be registered after treatment with total body hyperthermia (41.5 degrees C) for one hour three times during a 24 hour period.
|
|
| 2. |
- Bolmsjo, M., et al.
(author)
-
Experimental set-up for studies of microwave-induced hyperthermia in rats
- 1982
-
In: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 27:3, s. 397-406
-
Journal article (peer-reviewed)abstract
- A low-cost microprocessor-based temperature controller for hyperthermia experiments on rats is described. The system directs a microwave generator, used for heating, by feedback power regulating signals in accordance with the temperature in the animal. The microwave power is pulsed for short on-and-off periods and the temperature recordings are carried out during the off periods. More than 300 hyperthermia runs have been carried out on rats using this fully automated unit. The controller can direct the hyperthermia to the predetermined level with a deviation of +or-0.1 degrees C for systemic hyperthermia. For local hyperthermia in the liver, individual recorded mean temperatures were up to -0.5 degrees C from the preset temperature.
|
|
| 3. |
|
|
