| 1. |
- Callaghan, Terry, et al.
(author)
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Multi-Decadal Changes in Tundra Environments and Ecosystems : Synthesis of the International Polar Year-Back to the Future Project (IPY-BTF)
- 2011
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In: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 40:6, s. 705-716
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Journal article (peer-reviewed)abstract
- Understanding the responses of tundra systemsto global change has global implications. Most tundraregions lack sustained environmental monitoring and oneof the only ways to document multi-decadal change is toresample historic research sites. The International PolarYear (IPY) provided a unique opportunity for such researchthrough the Back to the Future (BTF) project (IPY project#512). This article synthesizes the results from 13 paperswithin this Ambio Special Issue. Abiotic changes includeglacial recession in the Altai Mountains, Russia; increasedsnow depth and hardness, permafrost warming, andincreased growing season length in sub-arctic Sweden;drying of ponds in Greenland; increased nutrient availabilityin Alaskan tundra ponds, and warming at mostlocations studied. Biotic changes ranged from relativelyminor plant community change at two sites in Greenland tomoderate change in the Yukon, and to dramatic increasesin shrub and tree density on Herschel Island, and in subarcticSweden. The population of geese tripled at one sitein northeast Greenland where biomass in non-grazed plotsdoubled. A model parameterized using results from a BTFstudy forecasts substantial declines in all snowbeds andincreases in shrub tundra on Niwot Ridge, Colorado overthe next century. In general, results support and provideimproved capacities for validating experimental manipulation,remote sensing, and modeling studies.
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| 2. |
- Stacey, Simon N, et al.
(author)
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A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
- 2011
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:11, s. 1098-103
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Journal article (peer-reviewed)abstract
- To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-wide association study of 16 million SNPs identified through whole-genome sequencing of 457 Icelanders. We imputed genotypes for 41,675 Illumina SNP chip-typed Icelanders and their relatives. In the discovery phase, the strongest signal came from rs78378222[C] (odds ratio (OR) = 2.36, P = 5.2 × 10(-17)), which has a frequency of 0.0192 in the Icelandic population. We then confirmed this association in non-Icelandic samples (OR = 1.75, P = 0.0060; overall OR = 2.16, P = 2.2 × 10(-20)). rs78378222 is in the 3' untranslated region of TP53 and changes the AATAAA polyadenylation signal to AATACA, resulting in impaired 3'-end processing of TP53 mRNA. Investigation of other tumor types identified associations of this SNP with prostate cancer (OR = 1.44, P = 2.4 × 10(-6)), glioma (OR = 2.35, P = 1.0 × 10(-5)) and colorectal adenoma (OR = 1.39, P = 1.6 × 10(-4)). However, we observed no effect for breast cancer, a common Li-Fraumeni syndrome tumor (OR = 1.06, P = 0.57, 95% confidence interval 0.88-1.27).
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| 5. |
- Yang, Derong, 1985, et al.
(author)
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Optimized brake-based control of path lateral deviation for mitigation of secondary collisions
- 2011
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In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering. - : SAGE Publications. - 2041-2991 .- 0954-4070. ; 225:D12, s. 1587-1604
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Journal article (peer-reviewed)abstract
- This paper considers brake-based lateral control of a passenger vehicle, for reducing secondary collision risk following an initial impact in a traffic accident. Since secondary collisions are associated with deviations from the original travel path, the control problem is formulated via brake control sequences that minimize lateral path deviation. Optimal sequences are found not to conform to any simple control mode; sometimes all brakes are released, sometimes all wheels are locked, or the brakes may be applied in differential mode. In general, the optimal strategy combines several such actuation modes, and analysis shows it is related to the utilization of instantaneous vehicle force and moment capacity, indicating that a closed-loop control strategy may be developed based on the real-time estimation of tyre force limits during the post-impact event. Yaw motion control is related to response discontinuity and multiple equilibria found in the optimal response - a small change in initial yaw velocity generates large changes in the ensuing vehicle motion and thus in the aimed equilibrium point of the vehicle's orientation. Overall it is found that braking control strongly influences the post-impact path of the impacted vehicle, and may therefore form the basis of a practical system for avoiding secondary collisions in future traffic accidents.
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| 6. |
- Yang, Derong, 1985, et al.
(author)
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Post-Impact Vehicle Path Control by Optimization of Individual Wheel Braking Sequences
- 2010
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Conference paper (other academic/artistic)abstract
- In this paper the effectiveness of brake-based path control under typical post-impact conditions is investigated. Accident analysis shows that the secondary collision in multiple-events accidents can be mitigated or avoided by reducing the lateral path deviation. In this study a numerical optimization scheme is formulated to minimize the maximum deviation from the original intended lane using individual wheel braking. The optimal braking sequences are analyzed and dynamic switching between several strategies is found to be necessary. In particular, two distinguished strategies are qualified at the vehicle body level. The results can be used to develop a robust closed-loop control strategy.
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