| 1. |
- Abrahamsson, Carl-Olof, et al.
(author)
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Xylosylated naphthoic acid-amino acid conjugates for investigation of glycosaminoglycan priming.
- 2008
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In: Carbohydrate Research. - : Elsevier BV. - 1873-426X .- 0008-6215. ; 343:9, s. 1473-1477
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Journal article (peer-reviewed)abstract
- Three different series of xylosylated naphthoic acid-amino acid conjugates containing one or two amino acid residues were synthesized for the investigation of glycosaminoglycan priming and potential use as anti-tumor drugs. All xylosylated naphthoic acid-conjugates inhibited the growth of normal lung fibroblasts to some extent, whereas the growth of tumor derived T24 carcinoma cells was not affected. There was no correlation between amino acid conjugation, retention time and the antiproliferative activity. Only one compound initiated the priming of glycosaminoglycans. Modification of the naphthalene ring with one or two amino acid residues did not have any effect on proteoglycan biosynthesis or glycosaminoglycan priming in T24 carcinoma cells.
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| 2. |
- Aili, Ulrika, et al.
(author)
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Antiproliferative effects of peracetylated naphthoxylosides.
- 2009
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In: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X. ; 19, s. 1763-1766
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Journal article (peer-reviewed)abstract
- The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.
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| 3. |
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| 4. |
- Bertani, Stefano, et al.
(author)
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Stretching-tunable external-cavity laser locked by an elastic silicone grating
- 2006
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In: Optics Express. - 1094-4087. ; 14:25, s. 11982-11986
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Journal article (peer-reviewed)abstract
- We demonstrate wavelength locking of a diode laser at 760 nm with feedback from an elastic transmission grating in the Littrow configuration. The laser was in a single longitudinal mode with a side-mode suppression of 20 dB. By stretching the grating the laser could be tuned over a few nm. The grating was fabricated in a silicone elastomer ( polydimethylsiloxane) by a moulding technique, and coated by a thin layer of Ti and Au to achieve an increased diffraction efficiency needed for efficient locking.
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| 5. |
- Ciosek Högström, Katarzyna, 1984-, et al.
(author)
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Impact of the flame retardant additive triphenyl phosphate (TPP) on the performance of graphite/LiFePO4 cells in high power applications
- 2014
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In: Journal of Power Sources. - : Elsevier BV. - 0378-7753 .- 1873-2755. ; 256, s. 430-439
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Journal article (peer-reviewed)abstract
- This study presents an extensive characterization of a standard Li-ion battery (LiB) electrolyte containing different concentrations of the flame retardant triphenyl phosphate (TPP) in the context of high power applications. Electrolyte characterization shows only a minor decrease in the electrolyte flammability for low TPP concentrations. The addition of TPP to the electrolyte leads to increased viscosity and decreased conductivity. The solvation of the lithium ion charge carriers seem to be directly affected by the TPP addition as evidenced by Raman spectroscopy and increased mass-transport resistivity. Graphite/LiFePO4 full cell tests show the energy efficiency to decrease with the addition of TPP. Specifically, diffusion resistivity is observed to be the main source of increased losses. Furthermore, TPP influences the interface chemistry on both the positive and the negative electrode. Higher concentrations of TPP lead to thicker interface layers on LiFePO4. Even though TPP is not electrochemically reduced on graphite, it does participate in SEI formation. TPP cannot be considered a suitable flame retardant for high power applications as there is only a minor impact of TPP on the flammability of the electrolyte for low concentrations of TPP, and a significant increase in polarization is observed for higher concentrations of TPP. (C) 2014 Elsevier B.V. All rights reserved.
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| 6. |
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| 7. |
- Ciosek, Katarzyna, et al.
(author)
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Energy storage activities in the Swedish hybrid vehicle centre
- 2009
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In: World Electric Vehicle Journal. - : MDPI AG. - 2032-6653. ; 3:4, s. 858-862, s. 2850-2854
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Journal article (peer-reviewed)abstract
- Significant efforts are put worldwide on developing new concepts for vehicle propulsion with the hybrid electric vehicle (HEV) being a prominent example. Hybrid technology is clearly a strategic future activity for automotive industries and in response to the rapid development in the area; the Swedish Hybrid Vehicle Centre (SHC) was formed in 2007 to join forces between Swedish industry and academia in the field. The centre emphasizes a holistic view to meet the environmental and societal needs with new technological solutions. The research within SHC is currently divided into three different themes whereof we here describe the Energy Storage theme with emphasis on the activities carried out at the involved universities in the current main project areas: Cell Properties, Electrode Materials and Electrolyte Additives. Examples are given on how these projects attacks the problems at hand separately, but also how we create synergy effects between the projects. As an example cell modelling is performed given a specific chemistry and cycling scheme, the same parameters are used for electrochemical experiments which provide macroscopic data that are connected with molecular level actions in the electrodes, the electrolyte, and the interfaces. All this is done using our base-line chemistry and a subsequent route is to investigate the role of different additives to overcome the limitations that are observed.
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| 8. |
- Ellervik, Ulf, et al.
(author)
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2-Bromoethyl glycosides for synthesis of glycoconjugates on solid support
- 2005
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In: Tetrahedron. - : Elsevier BV. - 0040-4020. ; 61:9, s. 2421-2429
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Journal article (peer-reviewed)abstract
- 2-Bromoethyl glycosides can easily and in high yields be transformed into sulfones by treatment with a suitable thiol followed by oxidation with mCPBA. The observation that the so formed sulfones were cleaved by treatment with NaOMe/MeOH was used to design a new safety catch linker for synthesis of glycoconjugates on solid support. (C) 2005 Elsevier Ltd. All rights reserved.
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| 9. |
- Jacobsson, Mårten, et al.
(author)
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Acid-Catalyzed Nucleophilic Aromatic Substitution: Experimental and Theoretical Exploration of a Multistep Mechanism.
- 2008
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In: Chemistry: A European Journal. - : Wiley. - 1521-3765 .- 0947-6539. ; 14:13, s. 3954-3960
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Journal article (peer-reviewed)abstract
- The mechanism for the acid-mediated substitution of a phenolic hydroxyl group with a sulfur nucleophile has been investigated by a combination of experimental and theoretical methods. We conclude that the mechanism is distinctively different in nonpolar solvents (i.e., toluene) compared with polar solvents. The cationic mechanism, proposed for the reaction in polar solvents, is not feasible and the reaction instead proceeds through a multistep mechanism in which the acid (pTsOH) mediates the proton shuffling. From DFT calculations, we found a rate-determining transition state with protonation of the hydroxyl group to generate free water and a tight ion pair between a cationic protonated naphthalene species and a tosylate anion. Kinetic experiments support this mechanism and show that, at moderate concentrations, the reaction is first order with respect to 2-naphthol, n-propanethiol, and p-toluenesulfonic acid (pTsOH). Experimentally determined activation parameters are similar to the calculated values (DeltaH(exp) ( not equal)=105+/-9, DeltaH(calcd) ( not equal)=118 kJ mol(-1); DeltaG(exp) ( not equal)=112+/-18, DeltaG(calcd) ( not equal)=142 kJ mol(-1)).
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| 10. |
- Jacobsson, Mårten, et al.
(author)
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Aromatic O-glycosylation
- 2006
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In: Carbohydrate Research. - : Elsevier BV. - 1873-426X .- 0008-6215. ; 341:10, s. 1266-1281
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Research review (peer-reviewed)abstract
- Carbohydrates carrying an aromatic aglycon are important natural products and thus key synthetic targets. However, due to the electron-withdrawing properties of aromatic rings, phenols are difficult to glycosylate. This review covers the most common carbohydrate donors used for aromatic O-glycosylation (anomeric acetates, halides, trichloroacetimidates and thioglycosides) as well as some less common donors. The scope of the review is to give practical examples of aromatic O-glycosylations and to offer guidelines for glycosylation of typical aromatic residues. Anomeric acetates or trichloroacetimidates, activated under acidic conditions, are preferred for electron rich aromatic aglycons, while glycosyl halides, activated using basic conditions, are preferred for electron deficient aromatic residues. (c) 2006 Elsevier Ltd. All rights reserved.
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