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- Gotherstrom, Cecilia, et al.
(author)
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Pre- and Postnatal Transplantation of Fetal Mesenchymal Stem Cells in Osteogenesis Imperfecta : A Two-Center Experience
- 2014
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In: Stem Cells Transnational Medicine. - : Oxford University Press (OUP). - 2157-6564 .- 2157-6580. ; 3:2, s. 255-264
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Journal article (peer-reviewed)abstract
- Osteogenesis imperfecta (OI) can be recognized prenatally with ultrasound. Transplantation of mesenchymal stem cells (MSCs) has the potential to ameliorate skeletal damage. We report the clinical course of two patients with OI who received prenatal human fetal MSC (hfMSC) transplantation and postnatal boosting with same-donor MSCs. We have previously reported on prenatal transplantation for OI type III. This patient was retransplanted with 2.8 x 10(6) same-donor MSCs per kilogram at 8 years of age, resulting in low-level engraftment in bone and improved linear growth, mobility, and fracture incidence. An infant with an identical mutation who did not receive MSC therapy succumbed at 5 months despite postnatal bisphosphonate therapy. A second fetus with OI type IV was also transplanted with 30 x 10(6) hfMSCs per kilogram at 31 weeks of gestation and did not suffer any new fractures for the remainder of the pregnancy or during infancy. The patient followed her normal growth velocity until 13 months of age, at which time longitudinal length plateaued. A postnatal infusion of 10 x 10(6) MSCs per kilogram from the same donor was performed at 19 months of age, resulting in resumption of her growth trajectory. Neither patient demonstrated alloreactivity toward the donor hfMSCs or manifested any evidence of toxicities after transplantation. Our findings suggest that prenatal transplantation of allogeneic hfMSCs in OI appears safe and is of likely clinical benefit and that retransplantation with same-donor cells is feasible. However, the limited experience to date means that it is not possible to be conclusive and that further studies are required.
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- Morshed, Muhammad Sarwar Jahan, et al.
(author)
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Integration of wireless hand-held devices with the cloud architecture : Security and privacy issues
- 2011
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In: Proc. - Int. Conf. P2P, Parallel, Grid, Cloud Internet Comput., 3PGCIC. - 9780769545318 ; , s. 83-88
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Conference paper (peer-reviewed)abstract
- Use of wireless hand held devices like mobile, PDA, laptop etc. is increasing rapidly. Many advanced users want more functionality with these wireless devices to manage their daily schedule. But most of the wireless hand-held devices have limited resource capability for robust functionality. Therefore cloud computing environment could be an alternative solution for these devices to support resource consuming applications. If the wireless hand held device is connected with the cloud, user can use more resource consuming applications and private data (stored in the cloud) from those devices. But privacy and security of the personal information and data make the user concern for using the cloud. The aim of the paper is to identify the security and privacy related risks and threats of the mass users as well as corporate users, if the wireless hand-held devices will be integrated with the cloud.
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