| 1. |
- Jain, Achint K., et al.
(author)
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Targeting of diacerein loaded lipid nanoparticles to intra-articular cartilage using chondroitin sulfate as homing carrier for treatment of osteoarthritis in rats
- 2014
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In: Nanomedicine. - : Elsevier BV. - 1549-9634 .- 1549-9642. ; 10:5, s. 1031-1040
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Journal article (peer-reviewed)abstract
- Targeted delivery of antiosteoarthritic drug diacerein to articular tissue could be a major achievement and soluble polysaccharide chondroitin sulfate (ChS) may be a suitable agent for this. Therefore, diacerein loaded solid lipid nanoparticles modified with ChS (ChS-DC-SLN) were prepared for synergistic effect of these agents to combat multidimensional pathology of osteoarthritis (OA). Prepared formulation were of size range 396. ±. 2.7. nm, showed extended release up to 16. h and increased bioavailability of diacerein by 2.8 times. ChS-DC-SLN were evaluated for their effect on histopathology of femoro-tibial joint of rat knee and amount of ChS and rhein (an active metabolite of diacerein) at targeted site. Concentration of rhein was significantly higher in case of ChS-DC-SLN (7.8. ±. 1.23. μg/ml) than that of drug dispersion (2.9. ±. 0.45. μg/ml). It can be stated that ChS served as homing to articular cartilage for targeting of drug. Thus, ChS-DC-SLN have great potential to enhance the overall efficacy of treatment for OA. From the Clinical Editor: This study demonstrates the feasibility of targeted delivery of diacerein to articular tissue using soluble polysaccharide chondroitin sulfate as the targeting vector. This approach has the potential to significantly increase anti-arthritic drug concentration in joints without leading to systemic toxicity
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| 2. |
- Singh, Sanjay Kumar, et al.
(author)
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Pharmacokinetic and tissue distribution study of solid lipid nanoparticles of zidovudine in rats
- 2014
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In: Journal of Nanotechnology. - : Hindawi Limited. - 1687-9503 .- 1687-9511. ; 2014
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Journal article (peer-reviewed)abstract
- Zidovudine-loaded solid lipid nanoparticles (AZT-SLNs) and zidovudine in solution were prepared and administered in rats. The aim of this research was to study whether the bioavailability of zidovudine can be improved by AZT-SLNs perorally to rats as compared to oral administration of zidovudine. Zidovudine was determined in plasma and tissues by reverse phase high performance liquid chromatography. The pharmacokinetic parameters of zidovudine were determined after peroral administration: area under curve of concentration versus time (AUC) for AZT-SLNs was 31.25% greater than AZT solution; meanwhile mean resident time (MRT) was found to be 1.83 times higher for AZT-SLNs than AZT solution. Elimination half life of zidovudine was also increased for SLN formulation. Tissue distribution pattern of zidovudine was changed in case of AZT-SLNs. AUC of zidovudine in brain and liver was found to be approximately 2.73 and 1.77 times higher in AZT-SLNs than AZT solution, respectively, indicating that AZT-SLNs could cross blood brain barrier. Distribution of zidovudine was approximately 0.95 and 0.86 times lesser in heart and kidney, respectively. It can be concluded from the study that oral administration of AZT-SLNs modifies the plasma pharmacokinetic parameters and biodistribution of zidovudine
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| 5. |
- Bhardwaj, Sanjay, et al.
(author)
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Technology Commercialization by Micro, Small and Medium Enterprises (MSMEs) in Indian Context : Challenges and Governmental Support Systems
- 2013
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In: Indian Journal of Economics and Business. - 0972-5784. ; 12
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Journal article (peer-reviewed)abstract
- Post-liberalization, level of protection imparted by Indian government to Micro, Small and Medium Enterprises (MSMEs) is gradually reducing. In the changed scenario, MSMEs need to complete with large companies, both Indian and foreign, with cost-competitive and good quality products. Due to limited resources available with MSMEs, they find it difficult to develop internal technologies and hence need to access technologies developed elsewhere. Technologies developed by public funded Research and Technology Organizations (RTOs) can support MSMEs. However, MSMEs should develop competence to commercialize technologies procured from public-funded RTOs, and also utilize available governmental support to meet the emerging challenges. This paper discusses the challenges and governmental support systems for technology commercialization, with relevant examples, from Indian MSMEs’ perspective.
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| 6. |
- Jain, Sanjay, et al.
(author)
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A Hierarchical Approach for Evaluating Energy Trade-offs in Supply Chains
- 2013
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In: International Journal of Production Economics. - : Elsevier BV. - 0925-5273. ; 146:2, s. 411-422
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Journal article (peer-reviewed)abstract
- Supply chain design and operational decisions may impact the energy needed to keep the products flowing through to the customers. It is a challenge to determine the energy consumption and even more challenging to understand the impact of design and operational decisions on the energy consumption along the supply chain. This paper presents a hierarchical simulation based approach for estimating the energy consumption to keep the products flowing through a supply chain. System dynamics simulation is used at a high abstraction level to understand the major factors that may affect the energy consumption. Discrete event simulation is then used to delve down in detail for evaluating the critical stages in the supply chain. A case study for a closed loop supply chain of forklift brakes is used as an example of application of the approach. (C) 2013 Elsevier B.V. All rights reserved.
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| 7. |
- Jain, Sanjay, et al.
(author)
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Multi-Resolution Modeling for Supply Chain Sustainability Analysis
- 2013
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In: Proceedings of the 2013 Winter Simulation Conference. - 9781479920778 ; , s. 1996-2007
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Conference paper (peer-reviewed)abstract
- Consumers are increasingly becoming conscious of the need to reduce environmental impact. This hasmotivated the industry to make efforts to improve the sustainability of their products and supply chains.Such efforts require the ability to analyze the sustainability of supply chains and potential improvements.A systematic approach is needed to evaluate the alternatives that may range from those at the supplychain configuration level to those for improving equipment at a production facility. This paper presents amulti-resolution modeling approach that allows analyzing parts of the supply chain at appropriate level ofdetail. The capability allows studying the supply chain at high level initially and iteratively drilling downto detailed levels in the identified areas of opportunity and evaluating associated improvement alternatives.Multi-resolution modeling directly relates the impact of improvement in one part of the supplychain to overall supply chain performance thus reducing analyst effort and time.
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| 8. |
- Jain, Sanjay, et al.
(author)
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Supply Chain Carbon Footprint Tradeoffs Using Simulation
- 2012
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In: Proceedings - Winter Simulation Conference. - 0891-7736.
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Conference paper (peer-reviewed)abstract
- Supply chain design and operational decisions may impact the carbon footprint of the products flowingthrough. It is a challenge to determine the carbon footprint and even more challenging to understand theimpact of design and operational decisions on the footprint. This paper presents a hierarchical simulationbasedapproach for estimating the carbon footprint of products flowing through a supply chain. SystemsDynamics simulation is used at a high abstraction level to understand the major factors that may affect thecarbon footprint. Discrete event simulation is then used to delve down in detail for evaluating the criticalstages in the supply chain. A case study for a closed-loop supply chain of forklift brakes is used as an exampleof implementation of the approach.
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