| 1. |
- Bell, Brian, et al.
(author)
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Sustainable Bridges – Past and Future. Reflections on a European Project 2003 – 2007
- 2023
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In: IABSE Congress 2023 New Delhi, Engineering for Sustainable Development. - : International Association for Bridge and Structural Engineering. ; , s. 690-698
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Conference paper (peer-reviewed)abstract
- Twenty years ago, in 2003, a European project was started to increase the sustainability of existing railway bridges. This paper summarises what was achieved and looks ahead. Nine Working Packages were organized: (1) Background material; (2) Guidance by stakeholders; (3) Condition Assessment and Inspection Guidelines; (4) Loads, Capacity and Resistance Guidelines; (5) Monitoring Guidelines; (6) Repair and Strengthening Guidelines; (7) Demonstration with Field testing of Bridges; (8) Demonstration on Monitoring on Bridges; and (9) Training and Dissemination.Some of the main results (from 4 Guidelines and 47 Background documents) are highlighted and some experiences, conclusions and thoughts about the future are given. Hidden strengths and weaknesses are discussed, analyses and codes for assessment can be improved, new monitoring and strengthening methods are available and life length can be prolonged.
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| 2. |
- Bien, Jan, et al.
(author)
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Prototype of exciter for vibration tests and concept of monitoring system : Sustainable Bridges Background document 5.6
- 2007
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Reports (peer-reviewed)abstract
- This report is a description of the main principles of the proposed monitoring system, testing procedures, techniques of data acquisition and processing. After general information on dynamic tests in the bridge monitoring the prototype of exciter is described. The main principles and assumptions according to its construction are presented. Tests of the exciter executed in laboratory conditions as well as in field are presented and discussed. General principles of the monitoring system based on vibration tests carried out by means of the built exciter are described. Practical application of the monitoring system based on vibration tests is described for example of a damage test carried out on a Demonstration Bridge located in Siechnice close to Wrocław.
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| 3. |
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| 4. |
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| 5. |
- Bell, Brian, et al.
(author)
-
Sustainable Bridges - Past and Future Reflections on a European Project 2003-2007
- 2023
-
In: IABSE Congress, New Delhi 2023: Engineering for Sustainable Development, Report. ; , s. 690-698
-
Conference paper (peer-reviewed)abstract
- Twenty years ago, in 2003, a European project was started to increase the sustainability of existing railway bridges. This paper summarises what was achieved and looks ahead. Nine Working Packages were organized: (1) Background material; (2) Guidance by stakeholders; (3) Condition Assessment and Inspection Guidelines; (4) Loads, Capacity and Resistance Guidelines; (5) Monitoring Guidelines; (6) Repair and Strengthening Guidelines; (7) Demonstration with Field testing of Bridges; (8) Demonstration on Monitoring on Bridges; and (9) Training and Dissemination Some of the main results (from 4 Guidelines and 47 Background documents) are highlighted and some experiences, conclusions and thoughts about the future are given. Hidden strengths and weaknesses are discussed, analyses and codes for assessment can be improved, new monitoring and strengthening methods are available and life length can be prolonged.
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| 6. |
- Bien, Jan, et al.
(author)
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Demonstration bridge C: Masonry Arch Structure : Sustainable Bridges Background document 7.4
- 2007
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Reports (peer-reviewed)abstract
- The bridge was selected as a typical masonry arch bridge for demonstration and testing of the project achievements. The age (built 1875), construction and span length (arch radius 4,97 m) of the structure are representative for masonry bridges in Europe. The bridge also doesn't have any technical documentation as most of old masonry bridges. From the practical point of view it is interesting that the track in service is placed asymmetrically, just on one side of the bridge.Within the works performed on the bridge the following activities can be distinguished:• NDT testing of the structure geometry and material in situ,• Laboratory test of specimens taken form the structure,• Numerical analyses for evaluation of the bridge load capacity and the ultimate load.
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| 7. |
- Bien, Jan, et al.
(author)
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Possibilities of unification of bridge condition evaluation : Sustainable Bridges SB-D3.3
- 2007
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Reports (peer-reviewed)abstract
- This report is presenting possibilities as well as some conceptions of European harmonization in the area of bridge condition assessment. The proposals are addressed to all railway authorities to stimulate discussion on potential needs and possible directions of the unification process. Solutions developed by the Project can be recommended for implementation in the next versions of the existing bridge management systems or in the anew created systems. The proposed concepts can be also applied as independent external computer-based tools of bridge condition assessment supporting the existing bridge management systems.The main objectives of the presented report can be listed as follows:• presentation of proposed basic terminology in the field of bridge condition assessment;• presentation and comparison of bridge geometry models which can be applied in computer systems supporting assessment of bridge condition;• presentation of proposal of hierarchical classification of bridge damages as a first step to harmonization of the procedure of bridge condition assessment;• presentation of proposal of quantitative measures for all basic types of bridge damages for improvement of precision and objectivity of condition assessment;• presentation of conception of bridge condition evaluation based on numerical quantificationof damages and supported by the computer expert tools.
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| 8. |
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| 9. |
- Cermona, Christian, et al.
(author)
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Field testing of old bridges
- 2007
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In: Sustainable bridges. - Wrocław : Dolnoslaskie Wydawnictwo Edukacyjne. - 9788371251610 ; , s. 423-433
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Conference paper (peer-reviewed)
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| 10. |
- Chen, Zhishan, et al.
(author)
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Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
- 2024
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Journal article (peer-reviewed)abstract
- Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
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