| 1. |
- Alrutz, Marie, et al.
(author)
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Projektledning
- 2013
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Book (pop. science, debate, etc.)abstract
- Projektledning är ett yrke med egen certifiering. Det pågår en spännande utveckling inom området och det blir allt viktigare att hålla sig ajour med utvecklingen.Det övergripande målet med den här handboken är att vara en ständigt aktuell heltäckande bok om projektarbete. Innehållsmässigt täcker den både frågor som har med struktur och styrning att göra och frågor om ledning av människor och mänskliga processer i grupp. Kompetens inom projekt byggs av både kunskap och erfarenhet. Vi följer kontinuerligt aktuell forskning inom dessa områden och bjuder in intressanta forskare att medverka som författare. Vi skildrar verkliga projekt och låter erfarenheterna få plats, både de bästa erfarenheterna och de utmaningar som man tagit sig igenom.Handboken är levande och det innebär att artiklar tas bort för att ge plats för nya, i takt med att den uppdateras fortlöpande.
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| 2. |
- Berg, Anne, 1981-
(author)
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Kampen om befolkningen : Den svenska nationsformeringens utveckling och sociopolitiska förutsättningar ca 1780–1860
- 2011
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Doctoral thesis (other academic/artistic)abstract
- The aim of this thesis is to problematize the western type of nation formation by characterizing and explaining the Swedish process of national identity construction during the Age of Revolution. Thus, the thesis sets out to investigate the political-hegemonic process of identity formation, redefinition and struggle between different political forces. In practise, the thesis develops a typology over different ideological identity projects according to their object of identity formation and their political content. Instead of classifying the projects into civic or cultural types of nationalisms, the scheme of official and counter-hegemonic ideological projects are used. The thesis also sets out to explain the character of the process studied. This is done by analyzing the socio-political conditions of existence of the different national ideological projects. This includes their relationship to the state, their social milieus and the social composition of the agents of nationalization. The thesis shows that the Swedish process can be characterized as a constant battle over the population: a battle over the national self-understanding amongst different layers of the population. The explanation of this character has to do with two existing conditions. Firstly, the existence of a state that supported some identity projects and prohibited others. The state produced a sphere of contest by, partially, allowing the establishment of a sphere of political communication. It also acted as an authority by facilitating the different agents with the political language of nationalism as the main arena of social struggle. The other important condition was the increasing economic modernization, which caused both social mobilization and differentiation – the pre-conditions for intra-class conflicts and inter-class conflicts. In the end this thesis argues, in contrast to the modernist theories in the field, which has underpinned the importance of social communication and state- or bourgeois-led cultural integration, that Sweden, as one of the so-called old continuous nations, was not a top-down project during this particular era. It was a project created from the top as well as from below – inside as well as outside the objects of national politics. It is this simultaneousness that is the main feature of identity formation. And, its explanation lies in the emerging liberal class society as a difference- and community-machine. Consequently, the thesis problematizes the common picture of how and why people became nationals in the western states during the great transformation.
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| 3. |
- Berndt, Sonja I., et al.
(author)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Journal article (peer-reviewed)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 4. |
- Davanian, H., et al.
(author)
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Gene Expression Profiles in Paired Gingival Biopsies from Periodontitis-Affected and Healthy Tissues Revealed by Massively Parallel Sequencing
- 2012
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:9, s. e46440-
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Journal article (peer-reviewed)abstract
- Periodontitis is a chronic inflammatory disease affecting the soft tissue and bone that surrounds the teeth. Despite extensive research, distinctive genes responsible for the disease have not been identified. The objective of this study was to elucidate transcriptome changes in periodontitis, by investigating gene expression profiles in gingival tissue obtained from periodontitis-affected and healthy gingiva from the same patient, using RNA-sequencing. Gingival biopsies were obtained from a disease-affected and a healthy site from each of 10 individuals diagnosed with periodontitis. Enrichment analysis performed among uniquely expressed genes for the periodontitis-affected and healthy tissues revealed several regulated pathways indicative of inflammation for the periodontitis-affected condition. Hierarchical clustering of the sequenced biopsies demonstrated clustering according to the degree of inflammation, as observed histologically in the biopsies, rather than clustering at the individual level. Among the top 50 upregulated genes in periodontitis-affected tissues, we investigated two genes which have not previously been demonstrated to be involved in periodontitis. These included interferon regulatory factor 4 and chemokine (C-C motif) ligand 18, which were also expressed at the protein level in gingival biopsies from patients with periodontitis. In conclusion, this study provides a first step towards a quantitative comprehensive insight into the transcriptome changes in periodontitis. We demonstrate for the first time site-specific local variation in gene expression profiles of periodontitis-affected and healthy tissues obtained from patients with periodontitis, using RNA-seq. Further, we have identified novel genes expressed in periodontitis tissues, which may constitute potential therapeutic targets for future treatment strategies of periodontitis.
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| 5. |
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| 6. |
- Folke, Carl, et al.
(author)
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Reconnecting to the biosphere
- 2011
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In: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 40:7, s. 719-738
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Journal article (peer-reviewed)abstract
- Humanity has emerged as a major force in the operation of the biosphere, with a significant imprint on the Earth System, challenging social-ecological resilience. This new situation calls for a fundamental shift in perspectives, world views, and institutions. Human development and progress must be reconnected to the capacity of the biosphere and essential ecosystem services to be sustained. Governance challenges include a highly interconnected and faster world, cascading social-ecological interactions and planetary boundaries that create vulnerabilities but also opportunities for social-ecological change and transformation. Tipping points and thresholds highlight the importance of understanding and managing resilience. New modes of flexible governance are emerging. A central challenge is to reconnect these efforts to the changing preconditions for societal development as active stewards of the Earth System. We suggest that the Millennium Development Goals need to be reframed in such a planetary stewardship context combined with a call for a new social contract on global sustainability. The ongoing mind shift in human relations with Earth and its boundaries provides exciting opportunities for societal development in collaboration with the biosphere-a global sustainability agenda for humanity.
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| 7. |
- Glimvall, Pontus, et al.
(author)
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Elevated levels of salivary lactoferrin, a marker for chronic periodontitis?
- 2012
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In: Journal of Periodontal Research. - : John Wiley & Sons. - 0022-3484 .- 1600-0765. ; 47:5, s. 655-660
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Journal article (peer-reviewed)abstract
- Background and Objective: Whole saliva is a complex mixture of fluids essential for the well-being of the oral hard and soft tissues. Saliva contains numerous anti- microbial proteins that help protect the oral ecosystem from infectious agents. Chronic periodontitis is an infectious chronic inflammatory condition that affects the tooth-supporting structures and leads to their destruction. The aim of the present study was to investigate differences in concentrations of salivary lacto- ferrin in subjects with and without periodontal disease and correlate these values with clinical variables associated with periodontal disease. Material and Methods: Stimulated whole saliva was collected from 17 subjects with chronic periodontitis and 17 periodontally healthy control subjects. Data relating to bleeding on probing, probing pocket depth and horizontal bone loss were registered. Concentrations of lactoferrin, lysozyme and IgA in stimulated whole saliva were quantified using ELISA. Results: Subjects with chronic periodontits showed higher concentrations of lac- toferrin in stimulated whole saliva compared with periodontally healthy control subjects (p < 0.05). Salivary concentrations of lactoferrin were positively corre- lated with bleeding on probing (p < 0.001) and the number of sites with probing pocket depth ‡ 6 mm (p < 0.001). Conclusion: Lactoferrin is raised in stimulated whole saliva in subjects with chronic periodontitis and is correlated with probing pocket depth ‡ 6 mm.
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| 8. |
- Gunnarsson, Rebeqa, et al.
(author)
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Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia
- 2011
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In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 96:8, s. 1161-1169
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Journal article (peer-reviewed)abstract
- Background High-resolution genomic microarrays enable simultaneous detection of copy-number aberrations such as the known recurrent aberrations in chronic lymphocytic leukemia [del(11q), del(13q), del(17p) and trisomy 12], and copy-number neutral loss of heterozygosity. Moreover, comparison of genomic profiles from sequential patients' samples allows detection of clonal evolution. Design and Methods We screened samples from 369 patients with newly diagnosed chronic lymphocytic leukemia from a population-based cohort using 250K single nucleotide polymorphism-arrays. Clonal evolution was evaluated in 59 follow-up samples obtained after 5-9 years. Results At diagnosis, copy-number aberrations were identified in 90% of patients; 70% carried known recurrent alterations, including del(13q) (55%), trisomy 12 (10.5%), del(11q) (10%), and del(17p) (4%). Additional recurrent aberrations were detected on chromosomes 2 (1.9%), 4 (1.4%), 8 (1.6%) and 14 (1.6%). Thirteen patients (3.5%) displayed recurrent copy-number neutral loss of heterozygosity on 13q, of whom 11 had concurrent homozygous del(13q). Genomic complexity and large 13q deletions correlated with inferior outcome, while the former was linked to poor-prognostic aberrations. In the follow-up study, clonal evolution developed in 8/24 (33%) patients with unmutated IGHV, and in 4/25 (16%) IGHV-mutated and treated patients. In contrast, untreated patients with mutated IGHV (n=10) did not acquire additional aberrations. The most common secondary event, del(13q), was detected in 6/12 (50%) of all patients with acquired alterations. Interestingly, aberrations on, for example, chromosome 6q, 8p, 9p and 10q developed exclusively in patients with unmutated IGHV. Conclusions Whole-genome screening revealed a high frequency of genomic aberrations in newly diagnosed chronic lymphocytic leukemia. Clonal evolution was associated with other markers of aggressive disease and commonly included the known recurrent aberrations.
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| 9. |
- Hallingbäck, Henrik, et al.
(author)
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Genetic correlations between spiral grain and growth and quality traits in Picea abies
- 2010
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In: Canadian Journal of Forest Research. - 0045-5067 .- 1208-6037. ; 40, s. 173-183
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Journal article (peer-reviewed)abstract
- In Norway spruce (Picea abies (L) Karst), spiral grain is a major cause of twist development in sawn timber; this problem could be addressed by breeding for reduced grain angles. This study presents estimates of genetic correlations between grain angle under bark and height and diameter growth, branch number, angle, and thickness; stem straightness. ramicorn occurrence, and pilodyn penetration using data from three progeny trials The genetic relationship between grain angle development and radial growth was also investigated by measuring multiple annual rings (3-15) in stem sections from two clonal trials Grain angles under the bark exhibited substantial heritability but near-zero genetic correlations with all the other traits studied. The genetic correlations between multiple ring grain angle and radial growth were also close to zero among all rings. However, radial growth exhibited positive genetic correlations with grain angles at specific distances from the pith and with radial grain angle trends, suggesting that the higher grain angles in Juvenile wood extend further from the pith as a result of increased radial growth Therefore, from a sawtimber perspective, the genetic relationship with radial growth may be unfavourable. despite the lack of genetic correlations between grain angle and radial growth at any particular annual ring
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| 10. |
- Hallingbäck, Henrik, et al.
(author)
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Genetic information from progeny trials: a comparison between progenies generated by open pollination and by controlled crosses
- 2013
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In: Tree Genetics and Genomes. - : Springer Science and Business Media LLC. - 1614-2942 .- 1614-2950. ; 9, s. 731-740
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Journal article (peer-reviewed)abstract
- When conifer progenies generated by open pollination are assessed in field tests, it is usually assumed that all progenies of the same mother are true half-sibs. This assumption may be invalid, leading to overestimation of additive genetic variation and heritability and to biased breeding values. From one Scots pine (Pinus sylvestris) and one Norway spruce (Picea abies) seed orchard, containing 28 and 36 parent clones, respectively, progenies generated by open pollination (OP) and by controlled crosses (CC) were planted in adjacent trials at two to three sites in southern Sweden. The tree height and diameter at breast height were measured, and genetic parameters based on these traits were estimated for OP and CC progenies separately, in order to enable comparisons. Narrow-sense heritability estimates for Scots pine and Norway spruce OP progenies (in the ranges 0.04-0.13 and 0.15-0.38, respectively) did not differ significantly from CC estimates (0.07-0.12 and 0.23-0.30), suggesting that OP-based heritability values were not overestimated to any great extent. Similarly, genetic correlations between OP and CC progenies were in the ranges of 0.87-0.88 and 0.74-0.77 for Scots pine and Norway spruce, respectively, being significantly lower than unity only in the case of Norway spruce. OP-based breeding values for both species should therefore correspond well with those predicted from CC progenies, albeit not perfectly for Norway spruce. In conclusion, the assumption of true half-sibs for OP progenies was not violated to the extent that genetic parameter estimates or breeding value predictions were seriously biased.
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