| 1. |
- Johansson, Eva-Liz, et al.
(author)
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Comparison of different routes of vaccination for eliciting antibody responses in the human stomach
- 2004
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In: Vaccine. - : Elsevier BV. - 0264-410X. ; 22:8, s. 984-90
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Journal article (peer-reviewed)abstract
- Determination of optimal routes to induce mucosal immune responses locally in the stomach and duodenum are important steps in the development of vaccines against Helicobacter pylori infection. In this study, we immunized H. pylori-infected individuals either nasally or rectally with a model antigen, i.e. cholera toxin B subunit, and compared the immune responses after these routes with the responses after oral or intrajejunal vaccination. Specific antibody levels in serum as well as specific antibody levels and antibody-secreting cells in biopsies from antrum and duodenum were determined by ELISA and ELISPOT methods. In contrast to oral vaccination, nasal and rectal vaccination did not induce significant increases in specific antibody-secreting cells either in the antrum or duodenum. Furthermore, when analyzing the antibody levels in saponin extracted biopsies, intrajejunal vaccination was superior to both nasal and rectal vaccination in inducing antigen-specific IgA levels in the stomach. We conclude that oral vaccination is the optimal route for induction of antigen-specific IgA antibody responses in the stomach and duodenum of humans, while nasal or rectal vaccination is less suitable for this purpose.
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| 2. |
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| 3. |
- Johansson-Synnergren, Mats, 1968, et al.
(author)
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Off-pump CABG reduces complement activation but does not significantly affect peripheral endothelial function: a prospective randomized study.
- 2004
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In: Scandinavian cardiovascular journal : SCJ. - : Informa UK Limited. - 1401-7431 .- 1651-2006. ; 38:1, s. 53-8
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Journal article (peer-reviewed)abstract
- OBJECTIVE--Cardiac surgery initiates a systemic inflammatory response, which may affect endothelial function. The aim of this study was to investigate if off-pump CABG (OPCAB) reduces the postoperative inflammatory response and affects endothelial function less than conventional on-pump CABG. DESIGN--Fifty-two patients submitted for elective CABG were included in a prospective, randomized study. Twenty-six patients were operated with, and 26 without cardiopulmonary bypass (CPB). Plasma levels of complement (C3a), cytokines (IL-8, TNF-alpha), endothelin-1 and neopterin were measured before and during surgery and 2 and 24 h after surgery. Endothelial function was assessed by forearm plethysmography and acetylcholine infusion in 30 patients 2-4 h after surgery. RESULTS--C3a and neopterin concentrations were significantly higher during and early after surgery in the CPB group while TNF-alpha and IL-8 tended to be higher in the CPB group but the difference did not reach statistical significance. Endothelial function did not differ significantly between the two groups. CONCLUSION--OPCAB reduces complement activation compared with on-pump CABG but does not significantly affect TNF-alpha and IL-8 release or endothelial function.
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| 4. |
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Efter Adorno
- 2003
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Editorial collection (other academic/artistic)
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| 8. |
- Johansson, Anders, 1968-, et al.
(author)
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Efter Adorno
- 2003
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Book (other academic/artistic)abstract
- Fjorton nyskrivna essäer om Theodor W. Adorno och hans eventuella aktualitet år 2003 - hundra år efter hans födelse.
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| 9. |
- Johansson, Anders, 1968-, et al.
(author)
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Inledning : Adorno och eftervärlden
- 2003
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In: Efter Adorno. - Göteborg : Glänta. - 9197457507 ; , s. 9-24
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Book chapter (other academic/artistic)abstract
- Introduktion till Adornos tänkande och samtida relevans
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| 10. |
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